Abstract Congenital heart disease (CHD) is the most frequent congenital malformation at birth and is associated with neurodevelopmental impairments. Alterations in cardiovascular physiology can lead to reduced cerebral blood perfusion..
Read MoreIntraoperative sodium range affects white matter microstructure in neonatal congenital heart disease
Abstract Background Intraoperative sodium changes and new postoperative white matter injury are prevalent in neonates with congenital heart disease (CHD) who undergo cardiopulmonary bypass surgery. Rapid sodium correction in hyponatremia..
Read MoreAbstract Objectives: Extracorporeal membrane oxygenation (ECMO) plays a crucial role in the outcome of children following surgery for congenital heart disease. However, its availability and affordability are minimal across the globe...
Read MoreAbstract Background:Infants with CHD who undergo cardiopulmonary bypass surgery are at risk of impaired growth and neurodevelopment. However, few studies have thoroughly investigated the risk factors for growth and neurodevelopmental..
Read MoreAbstract Background Children with congenital heart disease are at risk for poor neurodevelopment. The gut microbiome may influence neurodevelopmental outcomes through the gut-brain axis. This study investigated the association of..
Read MoreAbstract Objectives Neonates with complex congenital heart disease (CHD), in particular newborns with hypoplastic left heart syndrome (HLHS) or transposition of the great arteries (TGA), may show brain pathologies and..
Read MoreAbstract Introduction: The use of cardiopulmonary bypass (CPB) is necessary during the repair of most congenital heart disease (CHD). The surface area of the CPB circuit and the volume of..
Read MoreAbstract Objectives To describe the incidence and survival of extracorporeal membrane oxygenation (ECMO) deployment in the operating room (OR) for failure to wean from cardiopulmonary bypass (CPB) after surgery for..
Read MoreAbstract As survival among patients with congenital heart disease (CHD) continues to improve, the population of adults with CHD (ACHD) is rapidly growing. These patients often present with complex anatomy,..
Read MoreAbstract Aims Academic achievement of children with congenital heart disease (CHD) has not been comprehensively studied across the entire CHD severity spectrum. Methods and results Through nationwide registries, we identified..
Read MoreAbstract Background There is geographic disparity in the provision of Pediatric and Congenital Heart Disease (PCHD) services; Africa accounts for only 1% of global cardiothoracic surgical capacity. Methods We conducted..
Read MoreAbstract Background Congenital heart disease (CHD) that requires heart surgery is common. Severe postoperative pulmonary hypertension (PH) occurs in 2% of cardiac procedures and is associated with high morbidity and..
Read MoreAbstract Background The global prevalence of congenital heart disease (CHD) is increasing. Research on patient-reported outcomes (PROs) predominantly originates from high-income countries, resulting in an incomplete understanding of the true global..
Read MoreAbstract Background To evaluate the effect and safety of modified ultrafiltration warming technology during pediatric congenital heart disease (CHD) surgery. Methods A retrospective analysis included 68 children (<1 year) who..
Read MoreAbstract Objetives Extracorporeal membrane oxygenation (ECMO) after surgery for congenital heart disease (CHD) provides hemodynamic support to patients when their myocardial function is temporarily affected. Postoperative infections in children with..
Read MoreAbstract Introduction Amino acids (AAs) serve diverse roles, and insufficient delivery is associated with worse outcomes in ill patients. In the case of congenital heart disease (CHD) surgery with cardiopulmonary..
Read MoreAbstract Objective To assess the effects of dexmedetomidine (DEX) on cerebrovascular autoregulation in children with congenital heart disease (CHD) using transcranial color-coded duplex sonography (TCCD). Design Randomized controlled trial. Setting..
Read MoreAbstract Background: Plastic-containing medical devices are commonly used in critical care units and other patient care settings. Patients are often exposed to xenobiotic agents that are leached out from plastic-containing..
Read MoreAbstract Background Current indicators for monitoring intraoperative organ function remain predominantly indirect, delayed and non-specific, particularly in paediatric populations undergoing congenital heart surgery, where multifactorial influences further complicate functional assessments. Emerging..
Read MoreAbstract The use of extracorporeal membrane oxygenation (ECMO) in the paediatric population has increased over time, with the ability to rescue pulmonary and cardiovascular deterioration. ECMO can be utilised by..
Read MoreAbstract Background Some unrestrictive congenital shunts put patients at high risk for developing irreversible pulmonary vascular disease if not closed in the first year of life. Living at high altitude..
Read MoreAbstract Foramen ovale plays a key role in foetal circulation, however it may remain patent after birth throughout the life. Its patency is so frequent in healthy people (27-35 %),..
Read MoreAbstract Objective This study sought to evaluate the value of a CO2 field-flooding device in cardiopulmonary bypass (CPB) surgical procedures for congenital heart disease (CHD) performed via a right-side small incision..
Read MoreAbstract During pediatric cardiac surgery with cardiopulmonary bypass (CPB) for congenital heart disease, systemic hemodynamics dramatically change, which also causes changes in the cerebral hemodynamics. One of the representative methods..
Read MoreAbstract Congenital heart defects (CHDs) are one of the most common congenital malformations and often require heart surgery with cardiopulmonary bypass (CPB). Children undergoing cardiac surgery with CPB are especially..
Read MoreAbstract Objective This study was designed to investigate the distribution of nadir oxygen delivery (DO2), mean DO2, and area under ideal DO2 (AUiDO2) among categorized age groups of pediatric patients and..
Read MoreAbstract Adverse events (AEs) experienced by children and adults with congenital heart disease (CHD) on ventricular assist devices (VADs) are sometimes unique to these populations. The Advanced Cardiac Therapies Improving..
Read MoreAbstract Congenital heart disease (CHD) can be complicated by pulmonary arterial hypertension (PAH). Cardiopulmonary bypass (CPB) for corrective surgery may cause endothelial dysfunction, involving endothelin-1 (ET-1), circulating endothelial cells (CECs),..
Read MoreAbstract IMPORTANCE: Persistent hypothermia after cardiopulmonary bypass (CPB) in neonates with congenital heart defects (CHD) has been historically considered benign despite lack of evidence on its prognostic significance. OBJECTIVES: Examine..
Read MoreAbstract The gut microbiome of infants with congenital heart disease (CHD) undergoing cardiopulmonary bypass surgery (CPB) is at risk of profound alteration. The aim of this study was to examine..
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