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Perioperative Acute Kidney Injury: What’s New in 2025?

Abstract Perioperative acute kidney injury (AKI) is a frequent complication that affects outcomes well beyond the perioperative period. Its mechanisms remain incompletely understood, arising from the interplay of comorbidities, surgical..

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Preoperative untargeted SPME-LC/HRMS-based metabolomic profiling in cardiac surgical patients identified prognostic biomarkers for postoperative outcomes

Abstract Background Circulating metabolite profiles may reflect the physiological status before cardiac surgery and could contribute to predicting clinical outcome. Accordingly, metabolite levels may improve risk models as clinical models..

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Elevated oxygen extraction during heart transplantation is associated with increased morbidity and mortality: Implications for goal-directed perfusion

Abstract Background Goal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) commonly targets indexed oxygen delivery (DO2i), yet fixed delivery thresholds may ignore patient-specific metabolic demand. The oxygen extraction ratio (O2ER) integrates..

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A Perioperative Blood Conservation Protocol to Achieve Successful Bloodless Heart Transplantation

Abstract Heart transplantation (HT) is the definitive therapy for end-stage heart failure. Patients unwilling to receive blood product transfusions are often considered ineligible for HT due to the significant perioperative..

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Training communication skills in a multiuser medical virtual reality simulation: a qualitative, observational study

Abstract Background Simulation-based education is a well-established training technique in medical curricula, also for communication skills. Virtual reality (VR) technology can enhance this form of experience-based learning. How VR interacts..

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Modified cardiac power output as a marker for left ventricular recovery during V-A ECMO

Abstract Dear Editor, The timely liberation of cardiogenic shock (CS) patients from veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is crucial to reduce device  complications, although the predictor of weaning is..

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Pharmacological Research Agenda on Adult Extracorporeal Membrane Oxygenation Using the Delphi Method: A Position Paper of the Extracorporeal Membrane Oxygenation…

Abstract OBJECTIVES:  Extracorporeal membrane oxygenation (ECMO) is a critical intervention for patients with severe cardiac or respiratory failure. However, pharmacological management for ECMO-supported patients presents unique challenges due to alterations..

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Neuromonitoring Techniques in ECMO

Abstract Extracorporeal membrane oxygenation (ECMO) is a critical life-support therapy for patients with severe cardiac and/or respiratory failure, but it carries a significant risk of neurological complications. This narrative review..

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Continuous furosemide does not prevent cardiopulmonary bypass-related acute kidney injury in minimally invasive cardiac surgery: the randomized furosemide trial

Abstract Objectives: This study aimed to assess whether continuous furosemide administration during cardiopulmonary bypass (CPB) in minimally invasive cardiac surgery (MICS) reduces the incidence of cardiac surgery-associated acute kidney injury..

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UK multisociety consensus statement on the emergency management and resuscitation of patients with left-sided Impella support

Abstract The use of left-sided Impella microaxial flow pumps has expanded rapidly for the management of cardiogenic shock, left ventricular unloading and as a bridge to heart transplantation. However, standard..

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LVAD Implantation in Pediatric Population

LVAD Implantation in Pediatric Population inflow from LV and outflow to Ascending Aorta.   LVAD Implantation in the Pediatric Population   By Sam Zeraatiannejaddavani, MD   ⸻   A —..

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How to Prime an EVLP device

How to Prime an EVLP device from A to Z with back table LA and PA cuff srcuring and Dextran Priming as well connecting to EVLP.   Dr.Sam Zeraatian Nejad..

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Postoperative glycemic variability as a predictor for one-year mortality following coronary artery bypass grafting: a retrospective cohort study

Abstract Background Increased postoperative glycemic variability (GV) has been shown to be associated with an increased risk for adverse outcomes. However, the impact of postoperative GV on the long-term mortality..

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Association of Low Oxygen Delivery on Cardiopulmonary Bypass and Increased Long-Term Mortality

Abstract Background Although delivering less oxygen is associated with acute kidney injury, little is known about its association with long-term mortality and how the association may be modified by transfusion...

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Development and application of a novel framework for mobility & rehabilitation under support of extracorporeal life support: The MUSECLS framework

Abstract Introduction Mobility and rehabilitation for patients supported on extracorporeal life support (ECLS) are high-risk and resource-intensive endeavors that currently lack a standardized framework to guide comprehensive program development. This..

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Clinical Guideline for Treating Acute Respiratory Insufficiency with Invasive Ventilation and Extracorporeal Membrane Oxygenation: Updated Evidence- Based Recommendations for Choosing…

Abstract Invasive mechanical ventilation remains a cornerstone in the treatment of critically ill patients suffering from acute respiratory failure, providing life-sustaining gas exchange while necessitating careful selection of modes and..

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Effect of artificial intelligence in extracorporeal membrane oxygenation: a systematic review and meta-analysis

Abstract Objectives To evaluate the effectiveness of Artificial Intelligence (AI) in improving clinical outcomes in Extracorporeal Membrane Oxygenation (ECMO) management, focusing on ECMO initiation, prognosis, and complications. Methods A meta-analysis following..

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Optimizing IABP–patient interaction in VA-ECMO via transcranial doppler

Abstract Background Patients supported with veno-arterial extracorporeal membrane oxygenation may receive an intra-aortic balloon pump to reduce left ventricular afterload and improve aortic diastolic pressure. However, the effect of this..

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Chest Wound Gunshot Management Aided by Cardiopulmonary Bypass: Interdisciplinary Teamwork or “Serendipity”?

Abstract Background and clinical significance. Penetrating cardiothoracic wounds require prompt treatment in order to decrease mortality and morbidity. Surgical therapy, aimed at bleeding control and removal of damaged tissue, varies widely..

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Bilateral Lung Transplant

  Cardiopulmonary bypass is established following systemic heparinization to achieve an activated clotting time greater than four hundred and eighty seconds. Arterial cannulation is performed in the ascending aorta, while..

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Heart Recovery Techniques

Heart Recovery Techniques A. Donor Types 1. DBD (Donation after Brain Death) •Traditional and most common •Heart remains perfused until cross-clamp •Predictable ischemic time 2. DCD (Donation after Circulatory Death)..

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Inflammatory Cytokines as Early Predictors of Weaning Failure From Extracorporeal Life Support

Abstract Background Weaning from extracorporeal life support (ECLS) in patients with refractory shock still remains a complex decision. Despite considerable advances in ECLS management, reliable biomarkers to predict weaning success..

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Ketamine in Cardiac Surgery: A Systematic Review and Meta-Analysis of Effects on Inflammatory Markers and Clinical Outcomes

Abstract Cardiac surgery triggers a systemic inflammatory response, especially when cardiopulmonary bypass (CPB) is used, which may contribute to postoperative complications. Ketamine, an NMDA receptor antagonist, has shown anti-inflammatory potential..

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Evaluation of non-invasive sensors for monitoring core temperature

Abstract We evaluated the accuracy and precision of zero-heat flux (ZHF) and dual sensor (DS) non-invasive temperature probes in intensive care unit (ICU) patients undergoing hypothermic temperature control, hypothesizing that..

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Evaluation of Cardiac Output Estimation with Veno-Venous Extracorporeal membrane Oxygenation Support: in vitro study

Abstract Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is used to treat refractory lung failure, a condition that often results in right ventricular dysfunction, which can exacerbate both morbidity and mortality...

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Extracorporeal Membrane Oxygenation for Calcium Channel Blocker Intoxication: A Multicenter Retrospective Registry Review

Abstract Calcium channel blocker (CCB) toxicity can lead to cardiogenic shock and circulatory collapse. Extracorporeal membrane oxygenation (ECMO) has been used as salvage therapy when conventional treatments fail, but outcomes..

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Extracellular vesicles in cardiac surgery: unlocking new frontiers in cardioprotection and patient outcomes

Abstract Cardiac surgery, while life-saving, induces profound physiological stress due to ischemia–reperfusion injury (IRI), systemic inflammation, and endothelial dysfunction, particularly in procedures involving cardiopulmonary bypass. In this complex setting, extracellular..

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Diabetes Mellitus and Cardiopulmonary Bypass (CPB): Pathophysiological Mechanisms Related to Inflammation and Cardiovascular Disease

Abstract Type 2 Diabetes Mellitus (T2DM) is a chronic disease caused by the resistance of tissues to the actions of insulin as well as the progressive failure to produce adequate..

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Bleeding Complications from Chest Tube Treatment in Patients on Extracorporeal Membrane Oxygenation Support

Abstract Objectives Bleeding is a common complication of extracorporeal membrane oxygenation (ECMO) support. While chest tube treatment is infrequently linked to bleeding in non-ECMO patients, several reports suggest a markedly..

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Oxidative Stress and NLRP3 Inflammasome as Markers of Cardiac Injury Following Cardiopulmonary Bypass: Potential Implications for Patients with Preoperative Heart…

Abstract Cardiopulmonary bypass (CPB) can lead to cardiac damage due to oxidative stress (OS) and inflammation in heart failure (HF). We tested the hypothesis that preoperative HF patients with reduced..

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