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Synthetic, Population-Based Virtual Patient Database Using a Digital Twin of the Cardiovascular System

Abstract Purpose The goal is to develop a cardiovascular virtual patient database (VPD) combining physiological and demographic data to provide the foundation for future applications in medical diagnostics, decision-making, credibility..

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Rescue strategies combining ultra-protective ventilation and veno-venous ECMO in a patient with near-drowning-related severe ARDS: a case report and literature…

Abstract Background Drowning can lead to acute respiratory distress syndrome (ARDS), which is associated with high mortality and poses substantial clinical management challenges. Ultra-protective ventilation strategy combined with veno-venous extracorporeal..

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Kinetics of Sevoflurane Vaporized Directly in Extracorporeal Membrane Oxygenators—Ex Vivo Findings and Pharmacokinetic/Pharmacodynamic Simulations

Abstract Background Although sedation is commonly used in patients undergoing venovenous extracorporeal membrane oxygenation (V-V ECMO), the use of volatile anesthetics is less frequent, and there is limited data on..

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Arterial Cannulation and Brain Perfusion Strategies for Acute Type A Dissection in North America

Abstract Background This study was conducted to determine national trends and effect of cannulation and cerebral/brain perfusion (CP) strategies on outcomes during acute type A aortic dissection (ATAAD) surgery. Methods..

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Improving outcomes of patients with venovenous extracorporeal membrane oxygenation

Abstract Venovenous extracorporeal membrane oxygenation (VV ECMO) is a potentially lifesaving yet resource-intensive organ support option for patients with very severe respiratory failure refractory to optimized conventional management. Mortality remains..

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Hemocompatibility of Emergency Bypass System versus Permanent Life Support extracorporeal membrane oxygenation in a propensity score-matched cohort: analysis of hematologic…

Abstract Background The Emergency Bypass System (EBS, Terumo Corporation) and Permanent Life Support (PLS, MAQUET Cardiopulmonary GmbH) platforms differ in pump design and surface coating, which may influence hemocompatibility. This study..

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Artificial intelligence-guided tools in adult ECMO: Current advancements, emerging Trends and future directions

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) provides life support for patients with refractory cardiac or respiratory failure. The complexity of ECMO management and associated mortality necessitates high-accuracy clinical decision-making systems...

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Proactive versus resuscitative extracorporeal membrane oxygenation for low cardiac output syndrome after cardiac surgery

Abstract Objectives We sought to evaluate extracorporeal membrane oxygenation (ECMO) use for low cardiac output syndrome (LCOS) after congenital heart surgery. Our primary aims were (1) to compare hospital mortality..

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Surgical technique of donation after circulatory death heart procurement using direct procurement and hypothermic oxygenated perfusion preservation

Abstract Introduction Donation after circulatory death (DCD) has re-emerged as a means of expanding the donor heart pool. Current clinical practice relies mainly on direct procurement followed by normothermic machine..

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Hemolysis testing in circulatory support pumps: Standards, mock loops, and pulsatility

Abstract Hemolysis evaluation is central to the safety assessment of blood pumps and extracorporeal circulatory support, yet clinically relevant hemolysis continues to occur despite widespread use of standardized in vitro..

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Vascular implications of non-pulsatile flow extracorporeal life support

Abstract Extracorporeal life support has become a widely integrated tool in treating refractor cardiopulmonary failure. Under normal physiologic conditions, arterial blood flow is inherently pulsatile, and cyclic shear stress plays..

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Preventing Stroke in Aortic Arch Operations

Abstract Progress in aortic arch surgery has paralleled advances in cerebral protection. Since DeBakey’s first successful arch repair, neurologic complications have remained a major determinant of outcomes. The evolution of..

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Long-term quality of life and functional outcomes in extracorporeal membrane oxygenation survivors

Abstract Extracorporeal membrane oxygenation (ECMO) has become an increasingly vital intervention for patients with severe cardiac and respiratory failure, significantly improving short-term survival rates. However, there is growing recognition of..

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ELSO-score: A practical pre-ECMO risk model for predicting in-hospital mortality in patients receiving VA-ECMO

Abstract Background Despite advancements in management strategies, patients with refractory cardiogenic shock (CS) have high mortality. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly utilized as temporary mechanical support in these..

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Artificial Intelligence in Adult Cardiovascular Medicine and Surgery: Real-World Deployments and Outcomes

Abstract Artificial intelligence (AI) is rapidly reshaping adult cardiac surgery, enabling more accurate diagnostics, personalized risk assessment, advanced surgical planning, and proactive postoperative care. Preoperatively, deep-learning interpretation of ECGs, automated..

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Hemofilters versus hemodialyzers: impacts on cytokine removal during cardiopulmonary bypass in pediatric cardiac surgery: a randomized controlled trial

Abstract Background Congenital heart disease (CHD) remains a leading cause of pediatric morbidity and mortality worldwide. Cardiopulmonary bypass (CPB) is crucial for surgical repair but is associated with systemic inflammation..

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How to optimize brain perfusion and prevent cerebral complications during extracorporeal life support

Abstract Extracorporeal life support (ECLS) is increasingly used to rescue patients with refractory respiratory failure, cardiogenic shock and/or cardiac arrest. Acute brain injury during ECLS is common and associated with..

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2026 American Association for Thoracic Surgery Expert Consensus Document: Diagnosis and management of heparin-induced thrombocytopenia in patients who undergo cardiac…

Abstract Background Heparin-induced thrombocytopenia (HIT) in patients who undergo cardiac surgery presents unique diagnostic and management challenges due to universal perioperative heparin exposure, postoperative platelet kinetics, and the high prevalence..

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Prophylactic temporary mechanical circulatory support: The new paradigm in cardiac surgery

Abstract Background Post-cardiotomy cardiogenic shock (PCCS) remains one of the most lethal complications of cardiac surgery, with high in-hospital mortality despite major improvements in operative techniques, and intensive care management...

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A Novel Trans-Septal Cannula for Wearable Extracorporeal Membrane Oxygenation: In Vitro Hemodynamic Evaluation and Placement Feasibility

Abstract Extracorporeal membrane oxygenation (ECMO) supports patients with end-stage heart and lung disease awaiting transplantation. In pulmonary hypertension, veno-arterial ECMO (VA-ECMO) is common but linked to vascular complications and limited..

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Factors associated with device-associated health care-associated infections after cardiac surgery: a matched cohort study

Abstract Background The study aimed to identify the patient-related and procedure-related factors independently associated with the development of device-associated health care-associated infections (DA-HAIs) in cardiac intensive care unit (CICU), specifically..

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Hemodynamic monitoring during veno-venous extracorporeal membrane oxygenation: A scoping review

Abstract Background In adult patients receiving veno-venous Extracorporeal Membrane Oxygenation (VV ECMO), cardiovascular performance plays a critical role in determining oxygen delivery, organ perfusion and safe titration of extracorporeal support...

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Intraoperative respiratory exchange ratio to predict complications after cardiopulmonary bypass surgery: a retrospective cohort study

Abstract The respiratory exchange ratio (RER), defined as the ratio of carbon dioxide (CO2) production to oxygen (O2) consumption, may be a non-invasive and continuously measurable alternative to lactate for..

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Modified Extracorporeal Circulation (mECC) for enhanced blood conservation in thoracoabdominal aortic surgery: A single-center experience

Abstract Background Thoracoabdominal aortic aneurysm (TAAA) repair is associated with significant risks of blood loss and organ ischemia. This study evaluates the efficacy of a novel, modified Extracorporeal Circulation (mECC)..

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ECMO transports perspectives on organization and patient management: A narrative review

Abstract Background Extracorporeal membrane oxygenation (ECMO) is an established life support technique for refractory acute cardiorespiratory failure in children and adult patients. However, ECMO support is provided only by specialized..

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Use of extracorporeal circulation in multidisciplinary approach and replantation strategies for traumatic limb amputations: A case report

Abstract Background Traumatic major limb amputations require urgent intervention to prevent irreversible tissue necrosis and life-threatening systemic complications due to warm ischemia. We aim to demonstrate the efficacy of extracorporeal..

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Predictors and clinical outcomes associated with prolonged mechanical ventilation following major cardiac surgery

Abstract Background Prolonged mechanical ventilation (PMV) after major cardiac surgery is associated with increased morbidity, mortality, and healthcare utilization. Objectives To determine independent perioperative predictors of PMV and assess its..

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Goal-directed perfusion during cardiopulmonary bypass: Physiological rationale, clinical evidence, and critical appraisal

Abstract Objectives Cardiopulmonary bypass (CPB) is essential to cardiac surgery but is associated with organ injury from non-physiological perfusion. Goal-directed perfusion (GDP) has emerged as a physiology-based strategy to optimize..

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Extracorporeal life support in lung transplantation with dual-lumen cannulas: A systematic review

Abstract Background Refractory end-stage lung failure may benefit from extracorporeal life support (ECLS) as a bridge to lung transplantation. Venovenous (VV) extracorporeal membrane oxygenation (ECMO) is indicated in patients who..

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Association Between Core Body Temperature at the Time of Separation From Cardiopulmonary Bypass and Postoperative Acute Kidney Injury: A Retrospective…

Abstract Objectives Although hyperthermic perfusion (arterial outlet temperature >37°C) during cardiopulmonary bypass (CPB) is associated with acute kidney injury (AKI), the impact of body temperature at the time of separation..

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