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Prostaglandin Administration and Outcomes in Children on Extracorporeal Membrane Oxygenation

Abstract Objectives Extracorporeal Membrane Oxygenation (ECMO) is associated with high risks of bleeding and clotting. While traditional anticoagulants like heparin and bivalirudin target the coagulation cascade, prostaglandins including PGE1 and PGI2 may..

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Comparative decision-making analysis of extracorporeal membrane oxygenation candidacy based on a survey of pediatric critical care fellow and attending physicians

Abstract Background: Extracorporeal membrane oxygenation (ECMO) candidacy decisions for children with respiratory failure can be variable among pediatric critical care attending physicians, and prior studies showed that baseline functional status..

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Analysis of cerebral hemodynamics in neonates receiving extracorporeal membrane oxygenation support

Abstract Background Cerebral hemodynamic disturbances are common in neonates receiving extracorporeal membrane oxygenation (ECMO), yet systematic data describing changes in cerebral hemodynamics during ECMO support remain limited. This study was..

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Current use and limitations of direct thrombin inhibitors in pediatric ECMO: A European survey

Abstract Introduction Direct thrombin inhibitors (DTIs) are an alternative to unfractionated heparin during pediatric ECMO. We aimed to describe their use and limitations across Europe. Methods Fifty-two pediatric EuroELSO centers..

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Mobile versus in-center ECMO initiation in pediatric patients: a comparative outcome study

Abstract Background ECMO is indicated for respiratory or cardiopulmonary failure despite high oxygen levels, advanced ventilation, and patient optimization, when persistent hypoxemia/hypercapnia threatens life. Aim Compare characteristics and outcomes of..

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Early Initiation of Continuous Renal Replacement Therapy in Neonatal Extracorporeal Life Support: A 17-Year Retrospective Review

Abstract Neonatal fluid management in extracorporeal life support (ECLS) is complex, with the goal of improving outcomes while preventing complications. This study evaluates the impact of early continuous renal replacement..

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Reconsidering boundaries: extracorporeal membrane oxygenation candidacy for neonates with congenital anomalies of the kidney and urinary tract

Abstract The role of extracorporeal membrane oxygenation (ECMO) in neonates with congenital anomalies of the kidney and urinary tract (CAKUT) remains one of the more contested frontiers at the intersection..

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Physiology-Mimicking Microfluidic Oxygenator with Good Hemocompatibility for In Vitro Respiratory Support of Preterm Infants

Abstract Preterm infants, especially extremely preterm infants under 28 weeks of gestation, face high mortality rates due to respiratory distress resulting from pulmonary immaturity. Conventional mechanical ventilation and extracorporeal membrane..

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Anticoagulation Changes and Biochemical Signals Preceding Hospital-Acquired Infections in Pediatric Extracorporeal Support

Abstract Hospital-acquired infection (HAI) is a major complication in pediatric patients on extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT). Infection detection is challenging, as traditional inflammatory markers..

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Extracorporeal Cardiopulmonary Resuscitation in the Pediatric Cardiac Catheterization Laboratory: Incidence, Risk Scoring, and Outcomes

Abstract Pediatric patients undergoing cardiac catheterization are at risk of major adverse events, including cardiac arrest and the need for extracorporeal membrane oxygenation support. The primary aim of this study..

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Efficacy of universal genome sequencing in infant extracorporeal membrane oxygenation

Abstract Objective To evaluate the feasibility and diagnostic yield of universal genome sequencing (GS) in infants receiving extracorporeal membrane oxygenation (ECMO). Study design Prospective multicenter study across eight Children’s Hospital..

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Transfusion of blood products to neonatal and pediatric extracorporeal membrane oxygenation patients: A prospective, observational study

Abstract Study Question To describe the blood product utilization during neonatal and pediatric extracorporeal membrane oxygenation (ECMO) and to determine whether its usage correlates with clinical outcomes of bleeding, thrombosis..

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Plasma Biomarkers of Brain Injury in Critically Ill Children Receiving Extracorporeal Membrane Oxygenation

Abstract Importance  Timely identification of acute brain injury (ABI) in children receiving extracorporeal membrane oxygenation (ECMO) support is critical for early neuroprotective interventions. Objectives  To determine if elevations in plasma glial fibrillary..

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Outcomes after extracorporeal membrane oxygenation following the norwood procedure: a systematic review and meta-analysis

Abstract Background Survival following the Norwood procedure has improved substantially, but outcomes for the high-risk subgroup requiring postoperative extracorporeal membrane oxygenation (ECMO) remain unclear. We explored short- and intermediate-term outcomes..

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Impaired Cerebral Autoregulation in Pediatric Patients with ECMO: A Retrospective Analysis of ECMO Time Periods and Association with Neurologic Injury

Abstract Objective Neurologic injury is common in pediatric patients with extracorporeal membrane oxygenation (ECMO). Impaired cerebral autoregulation (CAR) may increase the risk of neurologic injury. We aimed to measure CAR..

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Feasibility of “Awake” Extracorporeal Membrane Oxygenation Cannulation Before Intubation in Children

Abstract When the risk of cardiopulmonary arrest during intubation is high, “awake” extracorporeal membrane oxygenation (ECMO) cannulation with sedation and a natural airway may provide hemodynamic stability and gas exchange..

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Neonatal extracorporeal membrane oxygenation outcomes according to social determinants of health

Abstract Objective To characterize relationships between social determinants of health (SDoH) and mortality among infants receiving extracorporeal membrane oxygenation (ECMO). Study design Retrospectively, we identified infants born >34weeks gestation and..

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Patterns of Multiple Organ Dysfunction in Children on Extracorporeal Membrane Oxygenation Support

Abstract We present the first characterization of multiple organ dysfunction (OD) patterns and their associations with in-hospital mortality for children on extracorporeal membrane oxygenation (ECMO). We retrospectively assessed OD for..

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Time to extracorporeal cardiopulmonary resuscitation flow and outcomes in paediatric in-hospital cardiac arrest: a 12-year single-centre study

Abstract Background Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory paediatric in-hospital cardiac arrest (IHCA). Although rapid initiation of extracorporeal life support (ECLS) is widely considered critical, the relative..

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Association between platelet indices and next-day bleeding and clotting in children and adults on extracorporeal membrane oxygenation: A retrospective study

Abstract Introduction Bleeding and clotting phenotypes are common in patients supported with Extracorporeal Membrane Oxygenation (ECMO) and are associated with increased mortality. However, tools to distinguish bleeding from clotting phenotypes..

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Pediatric Extracorporeal Cardiopulmonary Resuscitation (ECPR): Understanding Variations in Systems and Clinical Practice

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) for pediatric cardiac arrest relies on enhanced resources and time-critical decision-making. We aimed to evaluate variations in systems and clinical practice among extracorporeal membrane oxygenation..

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Neighborhood Opportunity and Long-Term Outcomes Following Pediatric Extracorporeal Membrane Oxygenation

Abstract Objective To evaluate whether neighborhood-level opportunity, measured by the Child Opportunity Index (COI), is associated with short- and long-term outcomes following pediatric extracorporeal membrane oxygenation (ECMO). Design Retrospective observational..

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Rethinking paracorporeal lung assist device support in the modern era: Why so different than ECMO?

Abstract Background Pediatric patients with combined irreversible pulmonary disease and right ventricular (RV) failure on conventional ECMO face significant challenges with rehabilitation and transplant candidacy. We describe our institutional experience..

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NAVA use in infants with established bronchopulmonary dysplasia, congenital diaphragmatic hernia, and those on ECMO: a narrative literature review

Abstract Neurally Adjusted Ventilatory Assist (NAVA) is an innovative mode of ventilation that delivers support in synchrony with the infant’s diaphragmatic electrical activity. This technology aims to improve patient–ventilator interaction,..

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Trends in Neonatal Extracorporeal Membrane Oxygenation (ECMO) in New York State: 2018-2024

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) has been used in the care of critically ill neonates since the 1970s. Some neonatal ECMO indications include inadequate tissue oxygen delivery, severe hypoxic..

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Left Ventricular Venting Using a Transaortic Pigtail Catheter in Pediatric Myocarditis Requiring Extracorporeal Membrane Oxygenation

Abstract Patients with fulminant myocarditis accompanied by severe hemodynamic deterioration, cardiogenic shock, or refractory arrhythmias often require venoarterial extracorporeal membrane oxygenation (VA-ECMO) treatment. When left ventricular (LV) dilation, elevated LV..

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Ischemic and hemorrhagic stroke in pediatric patients after extracorporeal membrane oxygenation decannulation: a systematic review

Abstract OBJECTIVE Extracorporeal membrane oxygenation (ECMO) is a vital support for pediatric patients with severe cardiac or pulmonary failure. However, post-decannulation complications, particularly involving carotid artery ligation (CAL) or carotid..

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Body Mass Index and Survival in Children Receiving Extracorporeal Membrane Oxygenation

Abstract Importance  Underweight and obesity represent opposite ends of the nutritional risk spectrum that negatively affect children’s health worldwide. Both conditions have been associated with increased mortality in pediatric patients receiving..

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Predictors of Brain Infarction in Pediatric Patients During Extracorporeal Membrane Oxygenation

Abstract Introduction Brain infarction (BI) is a severe complication of extracorporeal membrane oxygenation (ECMO) with high morbidity and mortality. We aimed to determine the incidence of BI and identify predictors..

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Anticoagulation management and monitoring in ECMO: an international survey: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis…

Abstract Objectives The objective of this survey is to assess current practices in anticoagulation management, laboratory monitoring, and hematology involvement in extracorporeal membrane oxygenation (ECMO) patients. Methods A cross-sectional international..

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