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A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up – towards an international prognostication guideline

Abstract Aims Pediatric cardiac arrest is associated with high mortality and significant morbidity among survivors. International guidelines for prognostication remain limited due to small heterogeneous patient populations, variable post-return of..

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Evaluating the impact of patient blood management implementation: a protocol for a quasiexperimental study in a Portuguese tertiary care setting

Abstract Introduction Patient blood management (PBM), an evidence-based, patient-centred approach for optimising blood health, faces significant implementation challenges despite regulatory support, and this study explores its adoption within a Portuguese hospital..

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Leveraging large language models for preoperative prevention of cardiopulmonary bypass-associated acute kidney injury

Abstract Background Acute kidney injury (AKI) usually occurs after cardiopulmonary bypass (CPB) and threatens life without timely intervention. Early assessment and prevention are critical for saving AKI patients. However, numerical..

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Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Abstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB) can impair end-organ perfusion and overall outcomes. This study..

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Vasoplegia Syndrome After Cardiac Surgery: Insights Into Mechanisms and Treatment

Abstract Vasoplegia syndrome is a specific form of vasodilatory shock encountered in patients who undergo cardiac surgery, most commonly with cardiopulmonary bypass, which is characterized by severe hypotension in the..

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A compact machine perfusion device for whole blood perfusion in isolated rat liver

Abstract We established a compact machine perfusion system for whole blood perfusion of rat liver by making use of oxygenation filters as an artificial lung. Livers removed from rats were..

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A rule-based clinical decision support system for detection of acute kidney injury after pediatric cardiac surgery

Abstract Background Acute kidney injury (AKI) is common in children with congenital heart disease following open-heart surgery with cardiopulmonary bypass (CPB). Early AKI detection in critically ill children requires clinician..

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Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Abstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB) can impair end-organ perfusion and overall outcomes. This study..

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Changing minds, saving lives: how training psychological safety transforms healthcare

Abstract Psychological safety is a crucial component in highly functioning healthcare teams, enabling every member to speak up, take innovative risks and admit mistakes without fear of personal attack or..

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Hemolysis in Extracorporeal Membrane Oxygenation: A Comparative Analysis of Venovenous Versus Venopulmonary Arterial Approaches

Abstract Venopulmonary arterial (VPA) extracorporeal membrane oxygenation (ECMO) is emerging as an alternative to traditional venovenous (VV) ECMO for respiratory failure. This study compares rates of hemolysis and acute kidney..

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Prognostic Value of Perioperative Near-Infrared Spectroscopy Monitoring for Postoperative Acute Kidney Injury in Pediatric Cardiac Surgery: A Systematic Review

Abstract Introduction Postoperative acute kidney injury (AKI) is a common postoperative complication in cardiac surgery, with varying reported incidences and prognostic factors. Renal hypoperfusion is believed to be a key..

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Development, validation, and clinical evaluation of a machine-learning based model for diagnosing early infection after cardiovascular surgery (DEICS): a multi-center…

Abstract Background:  This study addresses the critical need for timely and accurate diagnosis of early postoperative infection (EPI) following cardiac surgery. EPI significantly impacts patient outcomes and healthcare costs, making..

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A novel blood volume monitoring approach in a venous reservoir using a laser displacement sensor for blood surface distance measurement

Abstract A venous reservoir (VR) is crucial for safe blood volume regulation during cardiopulmonary bypass (CPB) procedures. Currently, blood volume measurement in VRs relies heavily on visual inspection, which limits..

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Impact of gender differences on optimal oxygen delivery thresholds to prevent acute kidney injury in cardiac surgeries with cardiopulmonary bypass

Abstract Background The nadir oxygen delivery index (DO2i) during cardiopulmonary bypass (CPB) is reportedly associated with acute kidney injury (AKI) in patients undergoing cardiac surgery. However, there are few reports..

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Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Abstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB can impair end-organ perfusion and overall outcomes. This study..

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Fine-Mapping the Association of Acute Kidney Injury With Mean Arterial and Central Venous Pressures During Coronary Artery Bypass Surgery

Abstract BACKGROUND:  Prior studies identified thresholds for mean arterial pressure (MAP <65 mm Hg) and central venous pressure (CVP >12 mm Hg) beyond which risk for cardiac surgery-associated acute kidney..

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Near-infrared spectroscopy to monitor cerebral and renal oxygen saturation during cardiopulmonary bypass surgery for paediatric congenital heart disease: study protocol…

Abstract Background Current indicators for monitoring intraoperative organ function remain predominantly indirect, delayed and non-specific, particularly in paediatric populations undergoing congenital heart surgery, where multifactorial influences further complicate functional assessments. Emerging..

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Pulsatile cardiopulmonary bypass using a centrifugal pump reduces acute kidney injury after cardiac surgery: a propensity score-matched analysis

Abstract Objective Acute kidney injury (AKI) affects approximately 30% of patients undergoing cardiac surgery with conventional non-pulsatile cardiopulmonary bypass (CPB). Pulsatile flow has long been proposed for mitigating this complication...

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Kidney protection during surgery on the thoracoabdominal aorta: a systematic review

Abstract OBJECTIVES Acute kidney injury (AKI) is a common consequence of surgical repair of the thoraco-abdominal aorta (TAA). Perfusion techniques aim to facilitate renal protection through oxygenation or hypothermia. This..

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Implementation of a goal directed perfusion strategy to reduce cardiac surgery associated kidney injury: A before and after study

Abstract Purpose Cardiac surgery associated acute kidney injury (CSA-AKI) is a frequent and severe complication. Goal Directed Perfusion (GDP) during cardiopulmonary bypass (CPB) has been developed to reduce post-operative complications,..

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How Would We Prevent Our Own Acute Kidney Injury After Cardiac Surgery?

Abstract Acute Kidney Injury (AKI) is a common complication after cardiac surgery affecting up to 40% leading to increased morbidity and mortality. To date, there is no specific treatment for..

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The World's First Hydromagnetic Artificial Heart: A Revolutionary Innovation in Cardiovascular Medicine

  Abstract Heart failure remains a leading cause of morbidity and mortality globally, particularly among individuals with advanced forms of the disease. This study introduces a groundbreaking hydromagnetic artificial heart..

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Kidney replacement therapy during extracorporeal membrane oxygenation: pathophysiology, technical considerations, and outcomes

Abstract The use of extracorporeal membrane oxygenation has been increasing over time, in part due to the COVID-19 pandemic. Whilst lifesaving, complications that must be managed are also associated with..

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Candidacy Decision Making for Extracorporeal Cardiopulmonary Resuscitation (ECPR): Lessons from a Single-Center Retrospective Analysis

Abstract Objective Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used to rescue patients in cardiac arrest. However, minimal data guide candidacy decisions, and centers must develop their own initiation criteria, raising..

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Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER-trial): a Randomized…

Abstract Background:  Postoperative Acute kidney injury (AKI) is a significant concern for cardiac surgery patients with chronic kidney disease (CKD). Effective pharmacological interventions to mitigate these risks are urgently needed...

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The hidden dangers of electronic cigarettes: e-cigarette, or vaping, product-use associated lung injury requiring extracorporeal membrane oxygenation

Abstract In recent decades, multiple efforts have been made to reduce population exposure to cigarettes, given that smoking is responsible for thousands of deaths annually. These actions have been effective,..

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Inhaled vs. intravenous vasodilators in perioperative pulmonary hypertension during chest surgery using cardiopulmonary bypass: A systematic review and meta-analysis

Abstract Perioperative pulmonary arterial hypertension (PAH) is a common complication of chest surgery with cardiopulmonary bypass (CPB) and its etiology is multifactorial. Patients undergoing this surgery often have underlying conditions,..

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Perioperative Bleeding Is Not an Independent Risk Factor for Acute Kidney Injury in On-pump Cardiac Surgery—A Post-hoc Analysis of a…

Abstract Objectives To study the association between bleeding and acute kidney injury (AKI). Design Post-hoc study of a randomized trial of 4% albumin versus Ringer's acetate for cardiopulmonary bypass priming..

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Fenoldopam use during Cardiopulmonary Bypass and Postoperative Rates of Acute Kidney Injury.

Abstract Acute kidney injury (AKI) is a complex clinical syndrome with a spectrum of clinical manifestations and outcomes (1); characterized by the deterioration of renal function over a period of..

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Goal-directed Perfusion to Reduce Acute Kidney Injury After Pediatric Cardiac Operation

Abstract Background Although goal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) has been discussed extensively in adult studies, no pediatric indexed oxygen delivery (Do2i) thresholds are universally accepted, and no pediatric..

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