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Cell-free hemoglobin is associated with microcirculatory perfusion disturbances and acute kidney injury in rats on extracorporeal membrane oxygenation

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment, but carries a high risk of complications such as acute kidney injury (AKI). A contributor to AKI is hemolysis, which..

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Assessment of Renal Vein Flow Index by Transesophageal Echocardiography: Precision, Variability, and Association with Cardiac Index During Cardiac Surgery

Abstract Objectives Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent and important complication often attributed to decreased kidney blood flow. Ultrasound measurement of renal  has been associated with adverse cardiac..

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Do Sex Differences Matter in Cardiac Surgery-Associated Acute Kidney Injury? – A Narrative Review

Abstract Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication following cardiac surgery. Despite growing awareness of sexual dimorphism in cardiovascular and chronic kidney disease, little is known about..

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Relationship between intraoperative blood pressure variability and postoperative acute kidney injury in pediatric cardiac surgery

Abstract Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is a notably common complication in pediatrics, with an incidence rate ranging from 15 to 64%. This rate is significantly higher than..

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Blood transfusion and acute kidney injury after cardiac surgery: a retrospective observational study

Abstract Purpose Cardiac surgery-associated acute kidney injury (AKI) is linked to poor outcomes. An observational study from Copenhagen, Denmark identified perioperative red blood cell (RBC) transfusion as a modifiable risk..

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Association between intraoperative lactate levels and acute kidney injury after on-pump cardiac surgery: a retrospective cohort study across two centers

Abstract Background Hyperlactatemia and acute kidney injury (AKI) represent significant perioperative complications in cardiac surgery. This study investigated their relationship by analyzing multiple lactate parameters during on-pump cardiac procedures. Methods..

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Is Cardiac Surgery Safe During GenAI exceeds clinical experts in predicting acute kidney injury following paediatric cardiopulmonary bypassPregnancy?

Abstract The emergence of large language models (LLMs) opens new horizons to leverage, often unused, information in clinical text. Our study aims to capitalise on this new potential. Specifically, we..

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Exploration of mortality-associated creatinine thresholds for acute kidney injury in cardiac surgery patients with impaired kidney function: a single-center retrospective…

Abstract Background Acute kidney injury (AKI) is a frequent and severe complication following cardiac surgery, particularly in patients with impaired kidney function. The existing Kidney Disease: Improving Global Outcomes (KDIGO)..

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Effects of increased cardiopulmonary bypass pump flow on renal filtration, perfusion, oxygenation and tubular injury in cardiac surgical patients -…

Abstract Background:  Cardiac surgery with cardiopulmonary bypass (CPB) is associated with impaired renal oxygenation and acute kidney injury. We investigated whether a higher than our standard blood flow during CPB..

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Impact of acute kidney injury and dysnatremia on length of stay in infants after cardiac surgery

Abstract Background Acute kidney injury (AKI) and dysnatremia following pediatric cardiac surgery are common conditions associated with worse outcomes. While the multifactorial etiology of AKI is well-known, the role of..

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Intravenous amino acids for renal protection in patients receiving temporary mechanical circulatory support: a secondary subgroup analysis of the PROTECTION…

Abstract OBJECTIVES In cardiac surgery patients, acute kidney injury (AKI) frequently occurs in the setting of haemodynamic instability and treatment with temporary mechanical circulatory support (tMCS). Recent evidence suggests amino..

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Tailored preoperative assessment in neonatal cardiac surgery: a European Congenital Heart Surgeons Association study

Abstract OBJECTIVES Current preoperative counselling in neonatal cardiac surgery is mainly focused on the primary procedure. However, other factors must be considered when evaluating the surgical risk of a neonate...

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Postoperative 20% Albumin Infusion and Acute Kidney Injury in High-Risk Cardiac Surgery Patients

Abstract Importance  Acute kidney injury (AKI) after cardiac surgery is a common and serious complication. Protein loading appears nephroprotective; thus, continuous hyperoncotic albumin infusion may impact AKI following high-risk cardiac surgery...

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Multivariable Modeling of Postoperative Risk in Infant Cardiac Surgery: Integrating Clinical Variables and 20 Inflammatory Biomarkers

Abstract Introduction Cardiac surgery in infants often triggers a severe inflammatory response. The role of biomarkers in predicting clinical outcomes in this group of patients has been debated in the..

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A randomized controlled trial on the impact of anesthetic agents on renal function in cardiac surgery with cardiopulmonary bypass

Abstract Acute kidney injury (AKI) is a frequent and severe problem following heart surgery, particularly in procedures involving cardiopulmonary bypass (CPB). This research investigates the Randomized Controlled Trial (RCT) on..

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A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up – towards an international prognostication guideline

Abstract Aims Pediatric cardiac arrest is associated with high mortality and significant morbidity among survivors. International guidelines for prognostication remain limited due to small heterogeneous patient populations, variable post-return of..

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Evaluating the impact of patient blood management implementation: a protocol for a quasiexperimental study in a Portuguese tertiary care setting

Abstract Introduction Patient blood management (PBM), an evidence-based, patient-centred approach for optimising blood health, faces significant implementation challenges despite regulatory support, and this study explores its adoption within a Portuguese hospital..

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Leveraging large language models for preoperative prevention of cardiopulmonary bypass-associated acute kidney injury

Abstract Background Acute kidney injury (AKI) usually occurs after cardiopulmonary bypass (CPB) and threatens life without timely intervention. Early assessment and prevention are critical for saving AKI patients. However, numerical..

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Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Abstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB) can impair end-organ perfusion and overall outcomes. This study..

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Vasoplegia Syndrome After Cardiac Surgery: Insights Into Mechanisms and Treatment

Abstract Vasoplegia syndrome is a specific form of vasodilatory shock encountered in patients who undergo cardiac surgery, most commonly with cardiopulmonary bypass, which is characterized by severe hypotension in the..

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A compact machine perfusion device for whole blood perfusion in isolated rat liver

Abstract We established a compact machine perfusion system for whole blood perfusion of rat liver by making use of oxygenation filters as an artificial lung. Livers removed from rats were..

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A rule-based clinical decision support system for detection of acute kidney injury after pediatric cardiac surgery

Abstract Background Acute kidney injury (AKI) is common in children with congenital heart disease following open-heart surgery with cardiopulmonary bypass (CPB). Early AKI detection in critically ill children requires clinician..

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Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Abstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB) can impair end-organ perfusion and overall outcomes. This study..

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Changing minds, saving lives: how training psychological safety transforms healthcare

Abstract Psychological safety is a crucial component in highly functioning healthcare teams, enabling every member to speak up, take innovative risks and admit mistakes without fear of personal attack or..

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Hemolysis in Extracorporeal Membrane Oxygenation: A Comparative Analysis of Venovenous Versus Venopulmonary Arterial Approaches

Abstract Venopulmonary arterial (VPA) extracorporeal membrane oxygenation (ECMO) is emerging as an alternative to traditional venovenous (VV) ECMO for respiratory failure. This study compares rates of hemolysis and acute kidney..

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Prognostic Value of Perioperative Near-Infrared Spectroscopy Monitoring for Postoperative Acute Kidney Injury in Pediatric Cardiac Surgery: A Systematic Review

Abstract Introduction Postoperative acute kidney injury (AKI) is a common postoperative complication in cardiac surgery, with varying reported incidences and prognostic factors. Renal hypoperfusion is believed to be a key..

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Development, validation, and clinical evaluation of a machine-learning based model for diagnosing early infection after cardiovascular surgery (DEICS): a multi-center…

Abstract Background:  This study addresses the critical need for timely and accurate diagnosis of early postoperative infection (EPI) following cardiac surgery. EPI significantly impacts patient outcomes and healthcare costs, making..

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A novel blood volume monitoring approach in a venous reservoir using a laser displacement sensor for blood surface distance measurement

Abstract A venous reservoir (VR) is crucial for safe blood volume regulation during cardiopulmonary bypass (CPB) procedures. Currently, blood volume measurement in VRs relies heavily on visual inspection, which limits..

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Impact of gender differences on optimal oxygen delivery thresholds to prevent acute kidney injury in cardiac surgeries with cardiopulmonary bypass

Abstract Background The nadir oxygen delivery index (DO2i) during cardiopulmonary bypass (CPB) is reportedly associated with acute kidney injury (AKI) in patients undergoing cardiac surgery. However, there are few reports..

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Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Abstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB can impair end-organ perfusion and overall outcomes. This study..

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