Abstract Liver transplantation (LT) is an established therapy for patients with end-stage liver disease. Advances in surgical technique, anesthetic management, and standardization of perioperative care have significantly improved outcomes, making..
Read MoreAbstract Background: Hemoperfusion has emerged as a potential extracorporeal blood purification strategy for attenuating inflammation during cardiopulmonary bypass (CPB), but perioperative biomarker trajectory data remain limited. This pilot comparative study..
Read MoreAbstract Background and Objectives: Prolonged intensive care unit (ICU) stay following coronary artery bypass grafting (CABG) remains a major clinical challenge. The aim of this study was to identify preoperative..
Read MoreAbstract Extracorporeal membrane oxygenation (ECMO) is a vital therapy for patients with severe cardiac and pulmonary failure. Despite technological advances, oxygenator dysfunction remains common, yet comparative clinical data across devices..
Read MoreAbstract Background Extracorporeal membrane oxygenation (ECMO) is a life-saving therapeutic modality in children. Outcome is multifactorial with debates regarding predictors of weaning success and mortality. Objective To explore predictors of..
Read MoreAbstract BACKGROUND We sought to determine if modified ultrafiltration (MUF) in the current era was associated with improved outcomes after neonatal cardiopulmonary bypass (CPB). METHODS Retrospective analysis of the PC4/NEPHRON..
Read MoreAbstract Background: Numerous studies have demonstrated that both cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are often associated with adverse outcomes or immune dysregulation when platelet counts decline during..
Read MoreAbstract Oxygenator thrombosis is a major complication during extracorporeal membrane oxygenation (ECMO), but systemic anticoagulation may be contraindicated by active hemorrhage, recent surgery, intracranial injury, or severe coagulopathy. Circuit-directed nitric..
Read MoreAbstract Background Levosimendan is often given during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support with the intention of facilitating weaning. The available evidence, however, has been derived largely from nonrandomized studies..
Read MoreAbstract Anaemia is a blood disorder that affects individuals of all ages, genders, and ethnicities. It results from a decrease in the number or functionality of erythrocytes or haemoglobin (Hb),..
Read MoreAbstract Background Extracorporeal membrane oxygenation (ECMO) provides circulatory and respiratory support in pediatric patients with life-threatening organ failure but can alter coagulation. Objectives To assess the relationship between a plasma..
Read MoreAbstract Introduction Goal-directed perfusion during cardiopulmonary bypass (CPB) has traditionally focused on indexed oxygen delivery (DO2i), yet metabolic behavior during aortic cross-clamping likely reflects a more complex interaction among oxygen..
Read MoreAbstract Objectives To determine the probability of a clinically relevant reduction in postoperative myocardial injury following the use of propofol-supplemented cardioplegia. Design Systematic review and Bayesian meta-analysis. Setting Perioperative cardiac..
Read MoreAbstract Atrial fibrillation (AF) is a highly prevalent arrhythmia and a major cause of morbidity and mortality. Although AF is not a primarily immunologic disorder, increasing clinical, translational, and experimental..
Read MoreAbstract Unfractionated heparin (UFH) exposure before cardiac surgery is ubiquitous. Patients who undergo urgent coronary surgery have almost invariably received intravenous UFH, and patients who undergo elective surgery receive it..
Read MoreAbstract Objective To investigate the outcomes of pediatric patients requiring extracorporeal membrane oxygenation (ECMO) after the Fontan operation. Methods We conducted a retrospective cohort analysis of the Extracorporeal Life Support..
Read MoreAbstract Background Decannulation from venovenous extracorporeal membrane oxygenation (ECMO) at the earliest safe opportunity would be expected to improve patient outcomes. Currently, the manner in which clinicians liberate patients from..
Read MoreAbstract Background The expanding availability of venovenous extracorporeal membrane oxygenation (ECMO) and the increasing frequency of prolonged ECMO runs challenge standard definitions of center experience based solely on patient counts...
Read MoreAbstract Objectives Safer cardiac surgery is being offered to more high-risk and frail patients, improving both survival and quality of life (QoL) for most. The QoL After Cardiac Surgery Study..
Read MoreEdinburgh NRP Masterclass – 18th-20th November 2026 An intensive three-day masterclass in abdominal Normothermic Regional Perfusion, combining expert-led teaching, practical simulation and hands-on training. Bringing together a multidisciplinary international faculty..
Read MoreAbstract Historically, extracorporeal membrane oxygenation (ECMO) in critical illness and respiratory failure has been used cautiously in patients with morbid obesity. However, recent data show favorable mortality outcomes for higher..
Read MoreAbstract Background Venous thromboembolism (VTE) is a common complication following lung transplantation, and perioperative extracorporeal membrane oxygenation (ECMO) use has increased substantially over time. The relationship between ECMO exposure and..
Read MoreAbstract BACKGROUND: Individuals who survive acute respiratory distress syndrome (ARDS) often face prolonged cognitive impairments. Comparable consequences have been observed in chronic hypoxic conditions, like COPD and obstructive sleep apnea..
Read MoreAbstract Background Cardiac surgery associated acute kidney injury (CSA-AKI) is a common and serious complication following cardiac surgery with cardiopulmonary bypass (CPB), associated with prolonged hospitalization, increased costs, and higher..
Read MoreAbstract Patients supported with extracorporeal membrane oxygenation (ECMO) represent a uniquely challenging population. These patients require specific interventions, such as repeated circuit and lower extremity perfusion assessments, anticoagulation management, frequent..
Read MoreAbstract Objectives Recent randomized controlled trials comparing extracorporeal cardiopulmonary resuscitation (ECPR) with conventional cardiopulmonary resuscitation (CCPR) reveal mixed outcomes; however, current data support an association between ECPR and neurologically intact..
Read MoreAbstract Lactate clearance is a key marker of oxygen delivery after neonatal cardiac surgery. While higher hematocrit (HCT) is often targeted to optimize oxygen delivery, its relationship with postoperative lactate..
Read MoreAbstract Awake extracorporeal membrane oxygenation (aECMO) has emerged as a strategy to minimise physical and neurocognitive complications of a prolonged intensive care admission. However, the safety and implementation in critically..
Read MoreAbstract The International Society on Thrombosis and Haemostasis (ISTH) recently published a survey on the management of unfractionated heparin (UFH), which revealed substantial heterogeneity in practice and highlighted the need..
Read MoreAbstract Existing risk stratification methods in cardiothoracic surgery do not use pre-operative bicarbonate levels. We investigate if these levels carry predictive value when compared with demographic, hematologic, and other renal..
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