Perfusfind S.L.
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Lactate clearance and volume status at cannulation are associated with survival in trauma VV ECMO patients

Abstract Background Veno-venous extracorporeal membrane oxygenation (VV ECMO) is an advanced therapy for patients with respiratory failure refractory to conventional management. Volume overload and elevated lactate levels have been associated..

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Perioperative albumin versus other fluids to prevent cardiac surgery-associated kidney injury: a systematic review and meta-analysis of randomized trials

Abstract Objective  Cardiac surgery-associated acute kidney injury is a common and serious complication of cardiac surgery. Albumin solution is a commonly administered fluid in cardiac surgery patients; the role of..

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ECMO for out of hospital refractory cardiac arrest in children: a retrospective multicenter analysis of a regional care program

Abstract Extracorporeal membrane oxygenation (ECMO) during cardiopulmonary resuscitation (ECPR) is a lifesaving technology that has been widely described for in-hospital cardiac arrest in children with underlying cardiac disease. However, data..

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Left ventricular unloading during VA-ECMO for refractory cardiogenic shock: a target trial emulation multicenter analysis

Abstract Background: Conflicting data exist regarding the survival benefit of mechanical left ventricular (LV) unloading in patients receiving peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock (CS). In..

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The TIMELESS Project: A Mixed-Methods Analysis of Modifiable Risk Factors and Transfusion Practices in 24,000 Cardiac Surgical Cases

Abstract BACKGROUND: Approximately 10% to 15% of all red blood cell (RBC) transfusions in the United States and United Kingdom occur during cardiac surgery. Despite efforts to standardize patient blood..

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Artificial hibernation: A new technique for protecting neural tissue and organs

Abstract With the rapid development of life support technologies in the biomedical field, artificial hibernation has shown significant potential in the area of neural tissues and organ protection. This paper..

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Extracorporeal CO2 elimination for acute exacerbation of severe COPD requiring invasive mechanical ventilation: a randomized controlled trial (the X-COPD trial)

Abstract Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) requiring invasive mechanical ventilation (IMV) are associated with high mortality and long-term disability. Extracorporeal CO₂ removal (ECCO₂R) using modern high-capacity..

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Impact of intra-aortic balloon pump support on cerebral blood flow velocity during venoarterial ECMO

Abstract Introduction Venoarterial extracorporeal membrane oxygenation (V-A ECMO) is frequently combined with intra-aortic balloon pump (IABP) support in patients with refractory cardiogenic shock. Although IABP may reduce V-A ECMO–related afterload,..

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Clinical and Functional Outcomes Following Repeat VA-ECMO in Adults: A Propensity Score–Matched Comparative Study

Abstract Background/Objectives: Evidence on outcomes after repeat VA-ECMO in adults remains limited. This study aimed to compare survival and post-discharge functional outcomes between adults requiring a second VA-ECMO run and..

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Pulmonary Artery Perfusion as a Rescue Strategy for Differential Hypoxemia During Partial Cardiopulmonary Bypass in Thoracoabdominal Aortic Replacement

Abstract Background Thoracoabdominal aortic replacement requires one-lung ventilation (OLV) and partial cardiopulmonary bypass (CPB). During right-sided OLV with femoral partial CPB, the coronary and supra-aortic branches are perfused by native..

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Blood-Based Versus Crystalloid Cardiopulmonary Bypass Priming in Left Ventricular Assist Device Surgery: Impact on End-Organ Function and Survival

Abstract Objectives Cardiopulmonary bypass (CPB) priming may influence haemodilution, bleeding, and end-organ injury during HeartMate 3 (HM3) implantation, but evidence in contemporary left ventricular assist device (LVAD) surgery is limited...

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ECMO artificial intelligence: matching the model to the clinical question

Abstract One theme worth emphasizing is that “ECMO prediction” is not a single task. Some models are intended to inform decisions before cannulation, whereas others incorporate variables such as ECMO..

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Hypothermic Oxygenated Machine Perfusion Using a Standard Cardiopulmonary Bypass System: Clinical Outcomes and Feasibility in Extended Criteria Donor Liver Transplantation

Abstract Objectives:Hypothermic oxygenated perfusion reduces ischemia-reperfusion injury and improves early graft function in extended criteria donor liver transplant. However, use of machine perfusion may be limited because of lack of..

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Veno-arterial-venous Extracorporeal Membrane Oxygenation with a Hemoconcentrator to Manage Transfusion Associated Hyperkalemic Arrest

Abstract Liver transplantation (LT) is an established therapy for patients with end-stage liver disease. Advances in surgical technique, anesthetic management, and standardization of perioperative care have significantly improved outcomes, making..

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Hemoperfusion integrated into the cardiopulmonary bypass circuit modifies perioperative inflammatory trajectories

Abstract Background: Hemoperfusion has emerged as a potential extracorporeal blood purification strategy for attenuating inflammation during cardiopulmonary bypass (CPB), but perioperative biomarker trajectory data remain limited. This pilot comparative study..

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Predictors of Prolonged ICU Stay After Isolated CABG: The Role of MiECC

Abstract Background and Objectives: Prolonged intensive care unit (ICU) stay following coronary artery bypass grafting (CABG) remains a major clinical challenge. The aim of this study was to identify preoperative..

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Comparative Performance of Oxygenators for Extracorporeal Membrane Oxygenation in Adults: A Retrospective Analysis

Abstract Extracorporeal membrane oxygenation (ECMO) is a vital therapy for patients with severe cardiac and pulmonary failure. Despite technological advances, oxygenator dysfunction remains common, yet comparative clinical data across devices..

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Extracorporeal membrane oxygenation in pediatric cardiac surgery: retrospective survival analysis

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a life-saving therapeutic modality in children. Outcome is multifactorial with debates regarding predictors of weaning success and mortality. Objective To explore predictors of..

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Modified Ultrafiltration and Association with Outcomes after Neonatal Cardiac Surgery

Abstract BACKGROUND We sought to determine if modified ultrafiltration (MUF) in the current era was associated with improved outcomes after neonatal cardiopulmonary bypass (CPB). METHODS Retrospective analysis of the PC4/NEPHRON..

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Immunothrombotic Dysregulation in Pediatric Patients Receiving Veno-arterial ECMO After Cardiac Surgery: Insights From Platelet Activation and T Cell Immune Profiling

Abstract Background: Numerous studies have demonstrated that both cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are often associated with adverse outcomes or immune dysregulation when platelet counts decline during..

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Circuit-Directed Nitric Oxide in Anticoagulation-Contraindicated Adult Extracorporeal Membrane Oxygenation: A Single-Center Case Series

Abstract Oxygenator thrombosis is a major complication during extracorporeal membrane oxygenation (ECMO), but systemic anticoagulation may be contraindicated by active hemorrhage, recent surgery, intracranial injury, or severe coagulopathy. Circuit-directed nitric..

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Levosimendan During VA-ECMO for Cardiogenic Shock: An Updated Systematic Review and Meta-analysis Including the LEVOECMO Trial

Abstract Background Levosimendan is often given during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support with the intention of facilitating weaning. The available evidence, however, has been derived largely from nonrandomized studies..

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A methylene blue based electrochemical assay to quantify haemoglobin in blood for point-of-care anaemia diagnosis

Abstract Anaemia is a blood disorder that affects individuals of all ages, genders, and ethnicities. It results from a decrease in the number or functionality of erythrocytes or haemoglobin (Hb),..

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Thrombin generation parameters provide independent information on plasma coagulation potential in pediatric patients on extracorporeal membrane oxygenation: a prospective, single-center…

Abstract Background Extracorporeal membrane oxygenation (ECMO) provides circulatory and respiratory support in pediatric patients with life-threatening organ failure but can alter coagulation. Objectives To assess the relationship between a plasma..

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Temperature-adjusted perfusion-metabolic phenotyping during cardiopulmonary bypass: An exploratory study

Abstract Introduction Goal-directed perfusion during cardiopulmonary bypass (CPB) has traditionally focused on indexed oxygen delivery (DO2i), yet metabolic behavior during aortic cross-clamping likely reflects a more complex interaction among oxygen..

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Propofol-Supplemented Cardioplegic Solution Effect on Myocardial Protection: A Systematic Review and Bayesian Meta-analysis of Randomized Controlled Trials

Abstract Objectives To determine the probability of a clinically relevant reduction in postoperative myocardial injury following the use of propofol-supplemented cardioplegia. Design Systematic review and Bayesian meta-analysis. Setting Perioperative cardiac..

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Leukocytes in atrial fibrillation: mechanisms and therapeutics

Abstract Atrial fibrillation (AF) is a highly prevalent arrhythmia and a major cause of morbidity and mortality. Although AF is not a primarily immunologic disorder, increasing clinical, translational, and experimental..

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From general guidance to surgical reality: Adapting the heparin-induced thrombocytopenia algorithm for cardiac surgery

Abstract Unfractionated heparin (UFH) exposure before cardiac surgery is ubiquitous. Patients who undergo urgent coronary surgery have almost invariably received intravenous UFH, and patients who undergo elective surgery receive it..

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Extracorporeal membrane oxygenation in children after Fontan operation

Abstract Objective To investigate the outcomes of pediatric patients requiring extracorporeal membrane oxygenation (ECMO) after the Fontan operation. Methods We conducted a retrospective cohort analysis of the Extracorporeal Life Support..

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Protocol and Statistical Analysis Plan for the ECMO-Free Trial

Abstract Background Decannulation from venovenous extracorporeal membrane oxygenation (ECMO) at the earliest safe opportunity would be expected to improve patient outcomes. Currently, the manner in which clinicians liberate patients from..

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