Tags Archives: cardiac surgery

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Hydroxyethyl starch and acute kidney injury in high-risk patients undergoing cardiac surgery: A prospective multicenter study

Abstract Background  (HES) solutions increase the risk of  (AKI) in critically ill patients admitted to intensive care unit (ICU) for medical indications. We conducted a cohort study to evaluate the renal..

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Feasibility of Healthcare Providers’ Autonomic Activation Recognition in Real-Life Cardiac Surgery Using Noninvasive Sensors

Abstract Cardiac surgery is one of the most complex specialties in medicine, akin to a complex sociotechnical system. Patient outcomes are vulnerable to surgical flow disruptions (SFDs), a source of..

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Reducing delirium and cognitive dysfunction after off-pump coronary bypass: A randomized trial

Abstract Background Neuropsychiatric complications of surgical  are inconspicuous but frequent and clinically relevant. So far, attempts to reduce their occurrence, such as the introduction of off-pump coronary artery bypass (OPCAB) grafting..

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Conventional versus minimally invasive extracorporeal circulation in patients undergoing cardiac surgery: protocol for a randomised controlled trial (COMICS)

Abstract Introduction: Despite low mortality, cardiac surgery patients may experience serious life-threatening post-operative complications, often due to extracorporeal circulation and reperfusion. Miniaturised cardiopulmonary bypass (minimally invasive extracorporeal circulation) has been..

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Minimal invasive extracorporeal circulation (MiECC): the state-of-the-art in perfusion

Abstract From the dawn of open-heart surgery in the early 1950s, a sequence of significant scientific achievements rendered cardiac surgery as a routine practice in the treatment of heart diseases...

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Efecto de la circulación extracorpórea sobre la perfusión microvascular en pacientes sometidos a cirugía cardíaca.

RESUMEN  La vía final común de los efectos de la circulación extracorpórea es la hipoperfusión periférica, que se valora indirectamente a través de la utilización de O2 en la periferia. El Orthogonal..

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Lesiones neurológicas durante la circulación extracorpórea: fisiopatología, monitorización y protección neurológica

RESUMEN La incidencia de lesiones neurológicas graves tras la cirugía cardíaca se ha establecido en un 6,1%: un 3,1% de lesiones focales y un 3% de lesiones difusas. Parece que..

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The association between intraoperative cell salvage and red blood cell transfusion in cardiac surgery – an observational study in a…

Abstract Cardiac surgery is commonly associated with high blood loss and the need for allogeneic red blood cell (RBC) transfusion. In addition, 20–30% of cardiac surgical patients suffer from anaemia..

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Cardiac Biomarkers for Risk Stratification of Acute Kidney Injury After Pediatric Cardiac Surgery

Abstract Background Children undergoing a cardiac surgical procedure are at increased risk for acute kidney injury (AKI). Novel biomarkers are needed to improve risk stratification of AKI after cardiac surgery...

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Vasopressor Therapy in Cardiac Surgery—An Experts’ Consensus Statement

Abstract Hemodynamic conditions with reduced  commonly are observed in patients undergoing cardiac surgery and may range from moderate reductions in , as a side effect of general anesthetics, to a profound vasodilatory..

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The diagnostic accuracy of procalcitonin in infectious patients after cardiac surgery: a systematic review and meta-analysis

Abstract Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute inflammatory response that may lead to a systemic inflammatory response syndrome. The interest in procalcitonin (PCT) in the diagnosis of..

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Point-of-Care Platelet Function Monitoring: Implications for Patients With Platelet Inhibitors in Cardiac Surgery

Abstract Although most physicians are comfortable managing the limited  effect of aspirin, the recent administration of potent P2Y12 receptor inhibitors in patients undergoing cardiac surgery remains a dilemma. Guidelines recommend discontinuation of..

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Peer-review of “A history of cardiac surgery: an adventurous voyage from antiquity to the artificial heart” by Ugo Filippo Tesler

Abstract The storytelling of contemporary cardiac surgery is narrated from early extra cardiac procedures to open heart surgery. The Italian author, Dr. Tesler, has been a testimonial of any step...

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Severity of hyperoxia as a risk factor in patients undergoing on-pump cardiac surgery

Abstract Background. Hyperoxia has long been perceived as a desirable or at least an inevitable part of cardiopulmonary bypass. Recent evidence suggest that it might have multiple detrimental effects on..

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Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery

Abstract Background.  Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ..

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Clinical Outcomes of Remote Ischemic Preconditioning Prior to Cardiac Surgery: A Meta‐Analysis of Randomized Controlled Trials

Abstract Background Multiple randomized controlled trials of remote ischemic preconditioning (RIPC) prior to cardiac surgery have failed to demonstrate clinical benefit. The aim of this updated meta‐analysis was to evaluate..

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RECCAS - REmoval of Cytokines during CArdiac Surgery: study protocol for a randomised controlled trial

Abstract Background On-pump cardiac surgery triggers a significant postoperative systemic inflammatory response, sometimes resulting in multiple-organ dysfunction associated with poor clinical outcome. Extracorporeal cytokine elimination with a novel haemoadsorption (HA)..

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A pilot study of perioperative esmolol for myocardial protection during on-pump cardiac surgery

Abstract The protective effects of preprocedural esmolol on myocardial injury and hemodynamics have not, to date, been investigated in patients who were scheduled for cardiac surgeries under a cardiopulmonary bypass..

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Active Bleeding after Cardiac Surgery: A Prospective Observational Multicenter Study

Abstract Main Objectives To estimate the incidence of active bleeding after cardiac surgery (AB) based on a definition directly related on blood flow from chest drainage; to describe the AB..

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The Relationship Between Oxygen Reserve Index and Arterial Partial Pressure of Oxygen During Surgery

Abstract BACKGROUND:  The use of intraoperative pulse oximetry (Spo2) enhances hypoxia detection and is associated with fewer perioperative hypoxic events. However, Spo2 may be reported as 98% when arterial partial pressure..

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Key Points for Curbing Cardiopulmonary Bypass Inflammation

Abstract PURPOSE: Cardiopulmonary bypass (CPB) procedures are thought to activate systemic inflammatory reaction syndrome (SIRS). Strategies to curb systemic inflammation have been previously described. However, none of them is adequate,..

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Fibrinogen supplementation after cardiac surgery: insights from the Zero-Plasma trial (ZEPLAST)

Abstract Background Fibrinogen supplementation has been proposed both to prevent and treat postoperative bleeding in cardiac surgery. The optimal fibrinogen concentration trigger and target values and the fibrinogen concentrate dose..

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Endothelial hyperpermeability after cardiac surgery with cardiopulmonary bypass as assessed using an in vitro bioassay for endothelial barrier function

Abstract Background.  The mechanisms causing increased endothelial permeability after cardiopulmonary bypass (CPB) have not been elucidated. Using a bioassay for endothelial barrier function, we investigated whether endothelial hyperpermeability is associated..

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Preoperative supplementation with fibrinogen concentrate in cardiac surgery: A randomized controlled study

Abstract Background.  Bleeding remains a severe complication in cardiac surgery. Several studies have found an association between the preoperative plasma concentration of fibrinogen and postoperative bleeding in cardiac surgery patients...

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Risk Factors Associated with Cognitive Decline after Cardiac Surgery: A Systematic Review

Abstract Modern day cardiac surgery evolved upon the advent of cardiopulmonary bypass machines (CPB) in the 1950s. Following this development, cardiac surgery in recent years has improved significantly. Despite such..

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Is low serum albumin associated with postoperative complications in patients undergoing cardiac surgery?

Abstract A best evidence topic was written according to a structured protocol. The clinical question investigated was: is low serum albumin associated with postoperative complications in patients undergoing cardiac surgery?..

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Intraoperative aortic dissection

Abstract Intraoperative aortic dissection is a rare but fatal complication of open heart surgery. By recognizing the population at risk and by using a gentle operative technique in such patients,..

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Meta-analysis of the cardioprotective effect of sevoflurane versus propofol during cardiac surgery

Abstract Background To evaluate the cardioprotective effects of sevoflurane versus propofol anesthesia in patients undergoing cardiac surgery. Methods Studies were retrieved through searching several databases. Study quality was evaluated by..

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Microvascular reactivity and clinical outcomes in cardiac surgery

Abstract Introduction Microvascular reactivity is decreased in patients with septic shock; this is associated with worse clinical outcomes. The objectives of the present study were to investigate microvascular reactivity in..

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Late Post-Conditioning with Sevoflurane after Cardiac Surgery - Are Surrogate Markers Associated with Clinical Outcome?

Abstract Introduction In a recent randomized controlled trial our group has demonstrated in 102 patients that late post-conditioning with sevoflurane performed in the intensive care unit after surgery involving extracorporeal..

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