Tags Archives: brain injury

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Impact of Root Venting on Brain Injury in Minithoracotomy Aortic Valve Replacement: Prospective Evaluation With Preoperative and Postoperative Brain MRI…

Abstract Background The predominant method for preventing cerebral infarction secondary to air embolism in cardiac surgery is the use of root vents to remove air. However, in the case of..

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Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation

Abstract Background Cardiac arrest (CA) remains a leading cause of mortality and long-term neurological disability. In cases of refractory CA, extracorporeal cardiopulmonary resuscitation (ECPR) may be implemented as a salvage..

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Neuron-Specific Enolase and S100B as Biomarkers of Ischemic Brain Injury During Surgery

Abstract Biochemical markers can be used in addition to neuroimaging techniques to evaluate the extent of ischemic brain injuries and to enable earlier diagnosis and faster intervention following the ischemic..

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Frontoparietal and temporal brain alterations post-cardiopulmonary bypass

Abstract Patients undergoing cardiopulmonary bypass (CPB) often experience neurological complications, but the neurobiological mechanisms remain unclear. This study combined resting-state fMRI, structural MRI, and cognitive testing to examine brain changes..

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Impaired cerebral autoregulation in children

Abstract Managing acute brain injury involves protecting the brain from secondary injury by addressing the mismatch between metabolic demand and cerebral perfusion. Observational studies have associated impaired cerebral autoregulation, a..

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Cerebral Inflammation in an Animal Ischemia–Reperfusion Model Comparing Histidine-Tryptophan-α-Ketoglutarate and Del Nido Cardioplegia

Abstract Brain injury and cerebral inflammation are frequent complications following cardiopulmonary bypass (CPB) resulting in neurocognitive dysfunction, encephalopathy, or stroke. We compared cerebral inflammation induced by del Nido and histidine-tryptophan-α-ketoglutarate..

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Standard versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release

Abstract Objectives To compare brain injury biomarker release levels between two different cardiopulmonary bypass (CPB) flow rates in elective cardiac surgery and to explore differences in postoperative delirium between groups..

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Improving Outcomes After Post–Cardiac Arrest Brain Injury: A Scientific Statement From the International Liaison Committee on Resuscitation

Abstract This scientific statement presents a conceptual framework for the pathophysiology of post–cardiac arrest brain injury, explores reasons for previous failure to translate preclinical data to clinical practice, and outlines..

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Predictive value of TCCD and regional cerebral oxygen saturation for detecting early postoperative brain injury

Abstract Objective This study aims to analyze the risk factors for early postoperative brain injury in patients undergoing cardiovascular surgery and explore the predictive value of transcranial color Doppler (TCCD)..

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Oxygenation During Venoarterial Extracorporeal Membrane Oxygenation: Physiology, Current Evidence, and a Pragmatic Approach to Oxygen Titration

Abstract OBJECTIVES:  This review aims to: 1) identify the key circuit and patient factors affecting systemic oxygenation, 2) summarize the literature reporting the association between hyperoxia and patient outcomes, and..

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Trends on Near-Infrared Spectroscopy Associated With Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation

Abstract We aimed to determine the association between cerebral regional oxygen saturation (rSO2) trends from cerebral near-infrared spectroscopy (cNIRS) and acute brain injury (ABI) in adult venoarterial extracorporeal membrane oxygenation (VA-ECMO) patients. ABI was defined as..

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Efficacy and safety of carbon dioxide insufflation for brain protection for patients undergoing planned left-sided open heart valve surgery: protocol…

Abstract Introduction Brain injury is common following open heart valve surgery. Carbon dioxide insufflation (CDI) has been proposed to reduce the incidence of brain injury by reducing the number of air..

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Neuromonitoring detects brain injury in patients receiving extracorporeal membrane oxygenation support

Abstract Objective There is limited evidence on standardized protocols for optimal neurological monitoring methods  receiving  (ECMO). We previously introduced protocolized noninvasive multimodal neuromonitoring using serial , electroencephalography,  ultrasound, and . The purpose of this study..

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Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal…

Abstract Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is an increasingly used rescue therapy forpatients with refractory cardiogenic shock (CS) 1,2 . It provides mechanical circulatory support for both heartand lungs..

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Hyperoxia and traumatic brain injury: time to stop cooking the books?

Abstract The excellent work by Rezoagli [1] on behalf of the CENTER-TBI and OxENTER-TBI consortia contributes further evidence of the potentially harmful effects of hyperoxia after traumatic brain injury (TBI)...

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High-Target Versus Low-Target Blood Pressure Management During Cardiopulmonary Bypass to Prevent Cerebral Injury in Cardiac Surgery Patients

Abstract Background: Cerebral injury is an important complication after cardiac surgery with the use of cardiopulmonary bypass. The rate of overt stroke after cardiac surgery is 1% to 2%, whereas..

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Neuromonitoring, neuroimaging, and neurodevelopmental follow-up practices in neonatal congenital heart disease: a European survey

Abstract Background Brain injury and neurodevelopmental impairment remain a concern in children with complex congenital heart disease (CHD). A practice guideline on neuromonitoring, neuroimaging, and neurodevelopmental follow-up in CHD patients..

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Cerebrum and Cardiac Protection with Allopurinol in Neonates with Critical Congenital Heart Disease Requiring Cardiac Surgery with Cardiopulmonary Bypass (CRUCIAL):…

Abstract Background Neonates with critical congenital heart disease (CCHD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk of brain injury that may result in adverse neurodevelopment. To date,..

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Routine Neuroimaging: Understanding Brain Injury in Pediatric Extracorporeal Membrane Oxygenation*

Abstract OBJECTIVES:  This project aims to describe brain injuries on routine neuroimaging in a large single-center neonatal and pediatric cohort supported by extracorporeal membrane oxygenation. The study also aims to..

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The use of a noninvasive intracranial pressure monitoring method in the intensive care unit to improve neuroprotection in postoperative cardiac…

Abstract Brain injury caused by extracorporeal circulation during cardiovascular surgical procedures has been a recurring complication since the implementation of extracorporeal circulation five decades ago. There is no unique cause..

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S100B in cardiac surgery brain monitoring: friend or foe?

Abstract Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant..

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The Use of Cerebral NIRS Monitoring to Identify Acute Brain Injury in Patients With VA-ECMO

Abstract Acute brain injury (ABI) increases morbidity and mortality in patients with veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Optimal neurologic monitoring methods have not been well-explicated. We studied the use of..

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Routine Neuroimaging. Understanding Brain Injury in Pediatric Extracorporeal Membrane Oxygenation

Abstract Objectives:  This project aims to describe brain injuries on routine neuroimaging in a large single-center neonatal and pediatric cohort supported by extracorporeal membrane oxygenation. The study also aims to..

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Early motor outcomes in infants with critical congenital heart disease are related to neonatal brain development and brain injury

Abstract Aim To assess the relationship between neonatal brain development and injury with early motor outcomes in infants with critical congenital heart disease (CCHD). Method Neonatal brain magnetic resonance imaging..

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Extracorporeal Life Support Organization (ELSO) Guidelines for Follow-up After Neonatal and Pediatric Extracorporeal Membrane Oxygenation

Abstract Neonates and children who have survived critical illness severe enough to require extracorporeal membrane oxygenation (ECMO) are at risk for neurologic insults, neurodevelopmental delays, worsening of underlying medical conditions,..

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Diffusion-weighted imaging detects early brain injury after hypothermic circulatory arrest in pigs

Abstract OBJECTIVES Cerebral injury is a complication of surgery with deep hypothermic circulatory arrest (DHCA). This study aimed to evaluate diffusion-weighted imaging (DWI) for the early detection of brain injury..

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Cognitive Dysfunction, Delirium, and Stroke in Cardiac Surgery Patients

Abstract Neurologic injury in the form of cognitive decline, delirium, and stroke are common phenomena in patients undergoing cardiac surgery and continues to be one of the most common complication..

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Domain‐specific cognitive dysfunction after cardiac surgery. A secondary analysis of a randomized trial

Abstract Background Brain injury and cognitive dysfunction are serious complications after cardiac surgery. In the perfusion pressure cerebral infarcts (PPCI) trial, we allocated cardiac surgery patients to a mean arterial..

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