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A Systematic Review of How Cardiopulmonary Bypass Parameters Influence Electroencephalogram Signals

Abstract Background: Cardiopulmonary bypass (CPB) is an essential technique for cardiac surgery but significantly increases the risk of perioperative neurological complications. Electroencephalography (EEG) enables real-time monitoring of brain function and..

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Impact of an Autotransfusion Device on Platelet Count and Transfusion Requirements in Cardiac Surgery: An Observational Study

Abstract Objectives To compare postoperative platelet counts in patients in whom intraoperative cell salvage (ICS) was performed using either a centrifugation-based device (ICS-centrifugation) or a filtration-based device (ICS-filtration; Same) for..

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Next generation spray-dried on-demand plasma: A multicenter, randomized, dose-escalation, first-in-human safety study

Abstract Background Prehospital plasma transfusion for patients at risk of hemorrhagic shock reduces mortality, but cold-chain and logistical constraints limit product availability. This study reports the first-in-human clinical evaluation of..

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Hypobaric type oxygenators during cardiopulmonary bypass for cardiac surgery to reduce gaseous microemboli: A randomized controlled trial

Abstract Objectives Neurological complications after cardiac surgery have been associated with gaseous microemboli generated during cardiopulmonary bypass. We undertook a trial to assess whether a novel dual-chamber oxygenator, designed to..

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60 years of ARDS and the evolution of extracorporeal lung support – from ECMO to ECCO2R

Abstract Extracorporeal life support (ECLS), including venovenous extracorporeal membrane oxygenation (VV-ECMO) and  extracorporeal carbon dioxide removal (ECCO₂R), is an established treatment for selected patients with acute respiratory distress syndrome (ARDS)...

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Low-Dose Postoperative Amino Acid Infusion and Kidney Protection After Cardiac Surgery: A Before-and-After Observational Cohort Study

Abstract Objectives To evaluate the real-world impact of implementing routine postoperative amino acid infusion on cardiac surgery–associated acute kidney injury (AKI). Design Before-and-after study. Setting Intensive care unit (ICU). Participants..

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Evaluating Four HIT Prediction Scores After Cardiac Surgery With Cardiopulmonary Bypass: A Comparative Study

Abstract Objectives To compare the diagnostic performance of 4 clinical prediction scores for heparin-induced thrombocytopenia (HIT) in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Design Bicentric retrospective observational study...

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Master in Cardiovascular Technology, Aarhus University

The Master’s programme prepares students to acquire the knowledge, skills and competencies required to analyse and assess clinical issues within cardiovascular technology, to identify and perform clinically relevant research projects..

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Evaluation of nursing performance during coronary artery bypass grafting surgeries using machine learning analysis of surgical videos: a multicenter retrospective…

Abstract Background Coronary Artery Bypass Grafting (CABG) is a high-risk, complex cardiac procedure that relies heavily on effective nursing collaboration to ensure surgical safety and improve patient outcomes. The advancement..

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Postoperative Bleeding Definitions as the Foundation of Hemostasis in Pediatric Cardiac Surgery

Abstract Effective perioperative hemostasis in pediatric cardiac surgery depends not only on accurate diagnostics and targeted transfusion strategies but also on a clear and consistent definition of postoperative bleeding. Despite..

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Predictive value of cerebral oxygenation with near infrared spectroscopy for in-hospital mortality in pediatric congenital heart disease surgery: a retrospective…

Abstract Aim Congenital heart disease still has significant morbidity and mortality despite advances in surgery. Inadequate tissue perfusion is thought to be the primary cause. Monitoring children with cerebral oxygenation..

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Prehabilitation clinic in cardiac surgery: multidisciplinary protocol for the improvement of postoperative outcomes

Abstract Background Prehabilitation in cardiac surgery is a multidisciplinary approach aimed at optimizing the clinical and functional status of patients awaiting elective procedures. Interventions addressing nutrition, physical activity, psychological support..

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Microcirculation and Cerebrovascular Autoregulation in Patients With Mechanical Circulatory Support Devices

Abstract Acute brain injury (ABI) affects up to one-third of patients using mechanical circulatory support (MCS). In venoarterial extracorporeal membrane oxygenation (VA ECMO), ABI incidence (11%-40%) has not improved in..

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Neurological complications in veno-arterial extracorporeal membrane oxygenation and the potential role of targeted temperature management– A narrative review

Abstract Background Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to provide circulatory support in acute cardiac failure. However, it is frequently complicated by neurological injury, which substantially worsens morbidity..

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Managing complex congenital anomalies during multi-organ donor procurement

    Managing complex congenital anomalies during multi-organ donor procurement requires precise surgical tailoring to preserve the structural integrity of the heart. When faced with a donor harboring both a..

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Microcirculation and Cerebrovascular Autoregulation in Patients With Mechanical Circulatory Support Devices

Abstract Acute brain injury (ABI) affects up to one-third of patients using mechanical circulatory support (MCS). In venoarterial extracorporeal membrane oxygenation (VA ECMO), ABI incidence (11%-40%) has not improved in..

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Determination of brain death in potential donors on ECMO support

Abstract Background A recent update of the German directive on determining brain death introduced changes regarding the diagnostics in potential donors on extracorporeal membrane oxygenation (ECMO). Physicians familiar with ECMO must..

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Teaching raters to see: A faculty development innovation for robust assessment in health professions education

Abstract Trustworthy simulation-based assessment depends on capable raters—but current approaches to rater training are often resource-intensive, inconsistently effective, and conceptually muddled. In practice, many programs focus on delivering training activities..

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Total trans septal approach and DCD rapid recovery

  Oxygenated Cardioplegia (OCP) using a blood-based vehicle represents a significant shift from traditional cold crystalloid preservation during multi-organ heart and lung procurements. By leveraging a mixture of oxygenated donor..

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Complex Heart-Lung Procurement and Back-Table Reconstruction

    Navigating the Anatomical Storm: Complex Heart-Lung Procurement and Back-Table Reconstruction   In the high-stakes arena of cardiothoracic transplantation, procurement surgery is often treated as a standardized exercise. Surgeons..

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Reliable Flow, Cost-Effective, Comfortable: Tunneled Veno-Pulmonary Artery Extracorporeal Membrane Oxygenation Cannulation Technique

Abstract Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) has many limitations, including patient comfort and, oftentimes, mobility issues. Veno-pulmonary (VP) ECMO offers respiratory support without recirculation and right heart support. For..

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Coronary slow flow: role of systemic inflammation and biomarkers in its pathophysiology

Abstract Background Coronary slow flow (CSF) is characterized by reduced coronary blood flow velocity in the absence of significant obstruction, and it has been associated with systemic inflammation and endothelial..

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Cardiopulmonary bypass time, intraoperative hematocrit and transfusion predict neurocognitive decline in patients undergoing cardiac surgery

Abstract Background Neurocognitive decline (NCD) after cardiopulmonary bypass is a well-established phenomenon. While numerous preoperative risk factors have been identified, the influence of intraoperative factors on NCD still needs further..

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Venovenous Extracorporeal Membrane Support in the Setting of Type A Aortic Dissection Repair—Too Little Too Late?

Abstract Background Use of venoarterial (VA) extracorporeal membrane oxygenation (ECMO) in the setting of type A aortic dissection (TAAD) has been described in the literature as salvage therapy, with morbid..

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The effects of mechanical ventilation during v-a ecmo support: a systematic review

Abstract Background Mechanical ventilation is routinely used during veno-arterial extracorporeal membrane oxygenation (V-A ECMO), but its role in influencing hemodynamics and supporting cardiac recovery remains poorly understood. This systematic review..

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Evaluation of a Novel Intelligent Interruption Management System in High-Fidelity Simulated Cardiac OR to Improve Surgical Safety

Abstract Surgical flow disruptions during complex cardiac surgery procedures may cause preventable errors and patient harm. Prior work has shown that timing interruptions during moments of lower cognitive workload (CogL)..

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Novel Extracorporeal Life Support System to Mitigate Ischemia-Reperfusion Injury During Prolonged Aortic and Inferior Vena Caval Occlusion

Abstract Extracorporeal membrane oxygenation (ECMO) and endovascular balloon occlusion of the aorta (REBOA) have been reported to manage hemodynamics and reduce blood loss and transfusion requirements during high-risk abdominal surgeries...

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The effect of intravenous calcium administration on haemodynamics in perioperative cardiothoracic surgery and intensive care: A narrative review

Abstract Calcium plays an essential role in myocardial contractility, excitation-contraction coupling, and vascular tone. In cardiothoracic surgery, calcium supplementation is frequently administered during weaning from cardiopulmonary bypass (CPB) and in..

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Outcomes after extracorporeal membrane oxygenation following the norwood procedure: a systematic review and meta-analysis

Abstract Background Survival following the Norwood procedure has improved substantially, but outcomes for the high-risk subgroup requiring postoperative extracorporeal membrane oxygenation (ECMO) remain unclear. We explored short- and intermediate-term outcomes..

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Blood Lactate Clearance as a Predictor of Mortality in Children Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Abstract Background: Pediatric cardiac surgery is still a high-risk procedure, with mortality being a significant concern. Lactate clearance has been demonstrated to enhance outcomes in critically ill adult populations; however, data..

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