Abstract The respiratory exchange ratio (RER), defined as the ratio of carbon dioxide (CO2) production to oxygen (O2) consumption, may be a non-invasive and continuously measurable alternative to lactate for..
Read More
Abstract Background Thoracoabdominal aortic aneurysm (TAAA) repair is associated with significant risks of blood loss and organ ischemia. This study evaluates the efficacy of a novel, modified Extracorporeal Circulation (mECC)..
Read More
Abstract Background Extracorporeal membrane oxygenation (ECMO) is an established life support technique for refractory acute cardiorespiratory failure in children and adult patients. However, ECMO support is provided only by specialized..
Read More
Abstract Background Traumatic major limb amputations require urgent intervention to prevent irreversible tissue necrosis and life-threatening systemic complications due to warm ischemia. We aim to demonstrate the efficacy of extracorporeal..
Read More
Abstract Background Prolonged mechanical ventilation (PMV) after major cardiac surgery is associated with increased morbidity, mortality, and healthcare utilization. Objectives To determine independent perioperative predictors of PMV and assess its..
Read More
Abstract Objectives Cardiopulmonary bypass (CPB) is essential to cardiac surgery but is associated with organ injury from non-physiological perfusion. Goal-directed perfusion (GDP) has emerged as a physiology-based strategy to optimize..
Read More
Abstract Background Refractory end-stage lung failure may benefit from extracorporeal life support (ECLS) as a bridge to lung transplantation. Venovenous (VV) extracorporeal membrane oxygenation (ECMO) is indicated in patients who..
Read More
Abstract Objectives Although hyperthermic perfusion (arterial outlet temperature >37°C) during cardiopulmonary bypass (CPB) is associated with acute kidney injury (AKI), the impact of body temperature at the time of separation..
Read More
Abstract Background Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a commonly used in refractory cardiogenic shock (CS) but may exacerbate left ventricular (LV) loading conditions and impair cardiac energetics. Adjunctive LV..
Read More
Abstract Background Extracorporeal circulation (ECC) is an essential operation in many cardiac surgeries, but contact between blood and connecting tubes can activate inflammatory factors and adversely affect complement. Previous studies..
Read More
Abstract In extracorporeal therapies such as cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO), the transport of blood through artificial circulation frequently results in the rupture of erythrocytes, releasing hemoglobin..
Read More
Abstract The Extracorporeal Life Support Organization (ELSO) has progressively transformed its guideline framework to meet the increasing clinical, scientific, and operational demands of modern extracorporeal life support. Since its establishment..
Read More
Abstract Background Takotsubo cardiomyopathy (TTC) is an episode of transient left ventricular (LV) dysfunction affecting 2.1% of patients with suspected acute ST-segment elevation myocardial infarction. Case Summary A 61-year-old woman..
Read More
Abstract As adult programs of newer anthrombotic agents, such as those directed against FXIa, are underway, there is both a pressing need and a great opportunity to optimize the design,..
Read More
Abstract Objectives To determine whether preoperative platelet (PLT) count independently predicts in-hospital mortality in patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO). Design Secondary analysis of a prospectively maintained institutional registry...
Read More
Abstract Background Patients undergoing cardiac surgery are at high risk of severe immediate postoperative complications. Predicting immediate postoperative adverse events remains challenging owing to the complex and nonlinear interplay of..
Read More
Abstract It seems logical to divide the macrocirculation into systemic and pulmonary circulation, but it is rare in clinical practice to further subdivide microcirculation into systemic and pulmonary microcirculation. Both..
Read More
Abstract Floating thrombi of the aortic arch constitute rare yet highly consequential lesions with high embolic risk for which optimal management remains debated. Conventional surgical management typically requires deep hypothermic..
Read More
Abstract Background Lung-protective ventilation in acute respiratory distress syndrome (ARDS) can lead to hypercapnia, an independent risk factor for increased mortality. Extracorporeal CO2 removal (ECCO2R) enables further reduction of ventilator intensity,..
Read More
Abstract Objective This study aimed to investigate the association of continuous renal replacement therapy (CRRT) use with the prognosis of patients undergoing extracorporeal membrane oxygenation (ECMO) and to explore its..
Read More
Abstract Objectives Previous studies have shown that Buckberg microplegia reduces the need for intraoperative blood transfusion by minimizing hemodilution. However, this approach has been largely understudied in the context of..
Read More
Abstract Objectives Whether patients with kidney failure who undergo cardiac surgery have a survival advantage with previous kidney transplantation is unclear. This study evaluated long-term outcomes after cardiac surgery for..
Read More
Abstract Background Acute kidney injury (AKI) is frequent in patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO), largely due to the severity of cardiogenic shock and multiorgan failure. Renal replacement..
Read More
Abstract Background Nearly 500,000 open-heart operations are performed annually in the United States, with complications such as postcardiotomy cardiogenic shock (PCCS) occurring in 2–9% of cases. Extracorporeal membrane oxygenation (ECMO)..
Read More
Abstract Background: Static or averaged electroencephalography (EEG) metrics may fail to capture dynamic cerebral changes during surgery. We assessed the EEG features during aortic arch surgery with cardiopulmonary bypass (CPB)..
Read More
Abstract Objective Postoperative days alive and out of hospital within 30 days (DAH-30) is a validated, patient-centered metric reflecting the quality of care and recovery after surgery. This study aimed..
Read More
Abstract Background Cardiogenic shock (CS) is a severe complication of ST-elevation myocardial infarction (STEMI) with high mortality despite advancements in treatment. Mechanical circulatory support (MCS) devices, such as extracorporeal membrane..
Read More
Abstract Lactate has traditionally been framed as a by-product of anaerobic metabolism and a surrogate for tissue hypoxia. Contemporary physiology recasts lactate as a central fuel, shuttle, and signaling molecule,..
Read More
Abstract Blood clots are pivotal for haemostasis and regeneration, but they are mechanically weak and form slowly, posing risks for life-threatening haemorrhage and limiting broader applications,,. These limitations are attributed..
Read More
Abstract Objective Vasoplegia and endothelial dysfunction are well-known complications of cardioplegia and cardiopulmonary bypass (CP/CPB). Our lab has previously shown that endothelial adherens junction impairment is driven by vascular endothelial..
Read More