Abstract Objectives To characterize how dabigatran, unfractionated heparin (UFH), and their reversal agents influence activated clotting time (ACT) and dabigatran-sensitive assays during cardiopulmonary bypass (CPB). Design In vitro human whole..
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Abstract Background Perioperative hyperglycemia is common in cardiac surgery and is associated with adverse outcomes; however, optimal intraoperative glucose targets remain incompletely defined. We evaluated the association between intraoperative glycemic..
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Abstract Background Recent international guidelines describe advance care planning (ACP) as evolving from isolated communication tasks toward an iterative, collaborative process integrating goals-of-care (GOC) discussions, documentation, clinical and ethical reasoning...
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Abstract Acute kidney injury (AKI) affects up to 50% of patients undergoing cardiopulmonary bypass, yet early diagnostic biomarkers and targeted therapies remain limited. Although AKI is attributed to bypass-induced renal..
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Abstract Background Postinfarct ventricular septal defect (PIVSD) is a rare but highly morbid complication after myocardial infarction (MI). Recent advances in extracorporeal life support (ECLS) therapies provide an option for..
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Abstract The use of extracorporeal membrane oxygenation Q4 (ECMO) as a temporary bridge to recovery, transplant, or durable device implantation is widely accepted. Major unease remains for patients already receiving..
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Abstract Rationale Acute kidney injury (AKI) is a common complication after adult cardiac surgery, affecting approximately 1 in 5 patients and conferring higher mortality, longer hospitalization, and increased resource use...
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Abstract Objectives To evaluate the effect of autologous platelet-rich plasma (aPRP) on perioperative allogeneic blood product transfusion requirement in patients undergoing cyanotic congenital heart disease (CCHD) surgery and patients’ prognosis...
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Abstract Background: Prone positioning and lung-protective ventilation are key components of the management of moderate-to-severe acute respiratory distress syndrome (ARDS). However, protective ventilation may be limited by refractory hypercapnia,..
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Abstract INTRODUCTION: Venovenous extracorporeal membrane oxygenation (VV ECMO) is a life‑saving intervention commonly used for severe and refractory respiratory failure. However, patient management and outcomes in this setting remain challenging..
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Abstract Adequate suppression of nociception remains a fundamental objective of modern cardiac anaesthesia. Interpretation of nociception monitoring during cardiac surgery involving cardiopulmonary bypass (CPB), however, is complicated by profound physiological..
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Abstract Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in 20-30% of patients after heart surgery with cardiopulmonary bypass (CPB). AKI rates are even higher in VA ECMO treated patients...
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Abstract Introduction Acute kidney injury is common after cardiac surgery requiring cardiopulmonary bypass, yet preventive strategies are limited. Progress has been hindered by a lack of clinically relevant experimental models..
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Abstract Objective The aim of this study was to investigate the maximum capacity of the Cytosorb adsorber for clearance of cell-free hemoglobin (cfHb) in a porcine cfHb solution in vitro...
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Abstract Introduction Deep hypothermic circulatory arrest (DHCA) is essential for pulmonary thromboendarterectomy (PTE). The optimal safe duration of DHCA remains controversial. This study evaluates the association between total DHCA duration..
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Abstract Background: This study aims to investigate the correlation between NIRS and S100B, and the effects of NIRS, S100B, and PerfSCORE parameters on morbidity and mortality in patients undergoing open-heart..
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Abstract Purpose of review Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival in selected patients with refractory cardiac arrest, but the benefit is steeply time-dependent. We examine the converging rationale for delivering..
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Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving therapy for refractory shock; however, gastrointestinal (GI) complications have been reported in up to 50% of these patients and contribute substantially..
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Abstract Left ventricular assist device (LVAD) explant heart transplantation represents a metabolically vulnerable population with an increased risk for renal failure and mortality. Oxygen extraction ratio (O2ER), which integrates oxygen..
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Abstract Despite decades of clinical experience, the physiological rationale for extracorporeal life support (ECLS) in acute respiratory distress syndrome (ARDS) remains incompletely defined. Existing trials have primarily evaluated ECLS as..
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Abstract Antithrombin (AT) depletion is common in critical illness, and during venovenous extracorporeal membrane oxygenation (VV ECMO), blood–surface interactions further amplify coagulation and inflammation cascades. The prognostic value of baseline..
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Abstract Objective Premature infants with congenital heart disease (CHD) face high perioperative mortality and neurological risk. We evaluated whether cardiopulmonary bypass timing independently influences mortality or neurologic injury in premature..
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Abstract Background Extracorporeal membrane oxygenation (ECMO) represents one of the most ethically challenging and clinically complex therapies used in pediatric critical care. Despite limited guidance and substantial practice variability, center-level..
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Abstract Background/Objectives: Preoperative anemia and iron deficiency increase transfusion risk in cardiac surgery. We evaluated outcomes associated with a Patient Blood Management (PBM) pathway and assessed the robustness of these..
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Abstract Background Systemic inflammatory response syndrome (SIRS) is a significant postoperative complication in older patients leading to higher morbidity and mortality rates. This study investigates the predictive value of preoperative..
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Abstract Background Intraoperative cell salvage is widely used in pediatric scoliosis surgery to reduce allogeneic transfusion requirements. However, its clinical effectiveness and economic impact remain uncertain. The objective of this..
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Abstract Purpose Out-of-bed (OOB) mobility is often expected of patients bridged to lung transplantation (LTx) on venovenous (VV) extracorporeal membrane oxygenation (ECMO), but the course of listed patients who never..
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Abstract Background Non-technical skills (NTS) such as teamwork, communication and leadership are essential for surgical safety, but their impact on patient outcomes is uncertain. This systematic review evaluated whether NTS..
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Abstract Coronary artery bypass grafting (CABG) utilizing cardiopulmonary bypass (CPB) remains a cornerstone of treatment for advanced multivessel coronary artery disease. During the ischemic period, myocardial cells become injured and..
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Abstract Background & Aims Postoperative renal failure remains a major determinant of morbidity and mortality after cardiac surgery, with limited preventive pharmacological options. Enoximone, a phosphodiesterase III inhibitor with inotropic..
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