Abstract Introduction Post-CPB bleeding remains a critical challenge in neonatal cardiac surgery, and early detection of coagulopathy to guide transfusion decisions may offer significant benefits. We hypothesized that routine use..
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Abstract Introduction Monitoring indexed oxygen delivery (DO2i) is recommended during cardiopulmonary bypass (CPB) and a predictor of acute kidney injury (AKI). The use of lean body mass-adjusted blood flow rates..
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Abstract Excessive right heart load imposes an acute or chronic injury on the right ventricle (RV), predisposing critically ill neonates and cardiac surgical patients to RV failure, low cardiac output..
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Abstract Background: Postoperative delirium is a common and serious complication in surgical patients, often leading to prolonged hospitalisation and increased morbidity. Intranasal insulin has shown promising results in preventing postoperative..
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Abstract Introduction Temporary mechanical circulatory support (tMCS) has become essential in managing severe cardiac dysfunction, particularly refractory cardiogenic shock (CS). Despite widespread adoption, the optimal use of tMCS is often..
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Abstract Neuron-specific enolase (NSE) is a marker used to assess neurological impairment. Notwithstanding, the release of NSE into the circulation can also originate from erythrocytes and thrombocytes, signifying that even..
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Abstract Background The predominant method for preventing cerebral infarction secondary to air embolism in cardiac surgery is the use of root vents to remove air. However, in the case of..
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Abstract Objectives: To test the feasibility and safety of a randomized controlled trial (RCT) delivering nitric oxide into the sweep gas of extracorporeal membrane oxygenation (ECMO) circuits (sNO) in critically..
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Abstract Background Postoperative complications in patients with acute type A aortic dissection (ATAAD) significantly affect their prognosis. This study investigates the association between cardiopulmonary bypass(CPB) weaning time and postoperative adverse..
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Abstract Introduction Significant blood loss (≥ 500 mL) during spinal surgery is common and linked to greater transfusion requirements and worse outcomes. Preoperative tools for risk stratification and individualized blood-management strategies..
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Abstract Background The purpose of this descriptive study was to characterize the utilization and outcomes of CPB after trauma. Methods This is an AAST-sponsored retrospective (2011-2021) multicenter (32 centers) study..
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Abstract Accurate, continuous assessment of regional tissue perfusion remains a significant clinical challenge, as most existing modalities are invasive, indirect, or impractical for routine monitoring. Near-infrared spectroscopy (NIRS) has been..
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Abstract Porcine livers have the potential to support liver function via extracorporeal liver cross-circulation (ELC) until recovery or transplantation. To assess the functional integrity of both native human and porcine..
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Abstract Background: The prognostic value of preoperative hemoglobin A1c (HbA1c) in patients undergoing cardiac surgery remains uncertain. This study investigated the association between preoperative HbA1c levels and the risk of..
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Abstract Objectives To evaluate the feasibility, safety, and early outcomes of a standardized operating room extubation (ORE) protocol implemented for elective cardiac surgery patients requiring cardiopulmonary bypass. Design A prospective..
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Abstract Background/Objectives: Cardiopulmonary bypass (CPB) facilitates complex cardiac surgery but can damage erythrocyte membranes, impairing microcirculation and oxygen transport. Standard rheological tests assess overall blood properties but fail to define..
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Abstract Objectives To monitor temporal changes in total and unbound remimazolam concentrations during cardiac surgery requiring cardiopulmonary bypass (CPB). Design Single-center, prospective, observational study. Setting Operating rooms of a university..
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Abstract Hemostasis depends on the coordinated interaction between platelets, coagulation factors, endothelium, and shear forces. Current point-of-care (POC) assays evaluate isolated components of haemostasis or operate under nearly static conditions,..
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Abstract ‘Liquid-like’ solid surfaces that overcome the limitations of lubricant-infused slippery surfaces, have garnered attention as passive antibiofouling coatings for biomedical applications. However, lack of intrinsic bioactivity limits its ability to..
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Abstract Due to the similar size ratios, adult porcine models are suitable for cardiovascular and circulatory physiology studies on extracorporeal circulation. As standard, the connection to the cardiopulmonary bypass (CBP)..
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Abstract In patients with or at risk of acute circulatory failure, capillary refill time (CRT) has emerged as a prognostic indicator, with data linking prolonged CRT to mortality and adverse..
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Abstract Antithrombin (AT), a glycoprotein, plays a key role in anticoagulation by inhibiting coagulation proteases. It is also the primary mediator of heparin's anticoagulant effect, with heparin binding amplifying AT..
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Abstract Background This study aimed to investigate the predictive value of the red cell distribution width-to-platelet ratio (RPR) for cardiac surgery-associated acute kidney injury (CSA-AKI). Methods A retrospective analysis of..
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Abstract Background: The Prognostic Nutritional Index (PNI) is a tool that combines serum albumin levels and lymphocyte count to assess a patient's nutritional and immune status. Malnutrition, often undetected in coronary..
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Abstract Background Patients with acute coronary syndrome requiring coronary artery bypass graft surgery while on ticagrelor face a high risk of perioperative bleeding because of its strong antiplatelet effect. The..
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Abstract Background Refractory cardiac arrest remains a major challenge in children, with poor survival despite advances in cardiopulmonary resuscitation (CPR). Extracorporeal cardiopulmonary resuscitation (ECPR), defined as rapid deployment of extracorporeal..
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Abstract BACKGROUND: Rotational thromboelastometry (ROTEM) is widely used for point-of-care coagulation testing to reduce blood transfusions. Accurate interpretation of ROTEM data is crucial and requires substantial training. This study investigates..
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Abstract Objectives To develop a multimodal pediatric critical care datamart supporting predictive modeling and decision support tool development, integrating high-resolution physiologic and clinical data and future clinical deployment. Materials and..
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Abstract Objective To assess how tranexamic acid (TXA) influences the renal outcomes of cardiovascular surgical patients. Design Systematic review and meta-analysis of randomized controlled trials (RCTs). Setting The operating room...
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Abstract Objectives Goal-directed perfusion strategies during cardiopulmonary bypass typically target indexed oxygen delivery thresholds to reduce acute kidney injury and other complications. This delivery-only paradigm may not fully reflect patient-specific..
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