Leveraging large language models for preoperative prevention of cardiopulmonary bypass-associated acute kidney injury
Abstract
Background
Acute kidney injury (AKI) usually occurs after cardiopulmonary bypass (CPB) and threatens life without timely intervention. Early assessment and prevention are critical for saving AKI patients. However, numerical data-driven models make it difficult to predict the AKI risk using preoperative data and lack preventive measures. Large language models (LLM) have demonstrated significant potential for medical decision-making, offering a promising approach.
Objective
For preoperative assessment and prevention of CPB-associated AKI (CPB-AKI).
Methods
Clinical variables were converted into text through prompt engineering and a LLM was used to extract information hidden in the semantics of subtle changes. A multimodal fusion model, fuzing semantic and numerical information, was proposed to assess the AKI risk before surgery. We then used a structural equation model to analyze the impact of preoperative features and intraoperative interventions on CPB-AKI prevention.
Results
A total of 2,056 patients who underwent CPB were enrolled from the intensive care unit of Sir Run Run Shaw Hospital between 2014 and 2022, with 40.5% progressing to AKI. Our model performed better with an area under the receiver operating characteristic curve of 0.9201 compared with the baseline models. The structural equation model’s chi-square to degrees of freedom ratio was 0.46, less than 2.0. We discussed how the preoperative prediction model could optimize intraoperative interventions to prevent CPB-AKI.
Conclusions
The prediction model can predict CPB-AKI risk earlier after fuzing the clinical characteristics and their semantics. Preoperative assessment and intraoperative interventions provide decision-making to prevent CPB-AKI.