Examining end-of-life care considerations within an Islamic context, the discussion delves into the intricate nuances surrounding ECMO patients. Drawing from Quranic teachings and Hadith principles, it underscores the sanctity of life and emphasizes compassionate decision-making. Advocating for integrating religious perspectives in healthcare highlights the importance of open dialogues, consultation with religious authorities, and respect for individual values. Islamic beliefs on life, death, and destiny shape the discourse on end-of-life care, focusing on dignity and quality of life preservation. Proposing a compassionate approach to ECMO discontinuation, the narrative emphasizes early consultations, transparent communication, shared decision-making, and advanced care planning for a dignified end-of-life journey.