CytoSorbents STAR Registry Data on Patients on Ticagrelor Undergoing CABG Surgery with CytoSorb Presented at EuroPCR 2024.

Perfusfind S.L.
Artículos, CytoSorbens Jan 1, 1970 0

PRINCETON, N.J., June 04, 2024 (GLOBE NEWSWIRE) — CytoSorbents Corporation (NASDAQ: CTSO), a leader in the treatment of life-threatening conditions in the intensive care unit and cardiac surgery using blood purification via its proprietary polymer adsorption technology, announces the recent data presentation entitled “Early CABG with Intraoperative Haemoadsorption in Patients on Ticagrelor: The Safe and Timely Antithrombotic Removal (STAR) Registry,” at the international EuroPCR 2024 conference in Paris, France – the world-leading course in interventional cardiovascular medicine with over 12,000 attendees – where it was also selected as a top 5 finalist in the best scientific abstract competition.

Professor Robert F. Storey, Academic Director and Honorary Consultant Interventional Cardiologist, Cardiology and Cardiothoracic Surgery Directorate, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK and Co-Principal Investigator of the international STAR Registry, presented real-world outcomes on 102 patients on ticagrelor (Brilinta®/Brilique®, AstraZeneca) who underwent non-deferrable coronary artery bypass graft (CABG) surgery with intraoperative CytoSorb® blood purification before completing the recommended 3-day drug washout period, across 23 European heart centers in Germany, U.K., Austria, Sweden, and Belgium.

  • In these 102 patients, the mean time from the last dose of ticagrelor was 22.8 hours. The mean age was 63.8 years, approximately 80% were male, and 43% had diabetes
  • There were no device-related adverse events reported by investigators using intraoperative CytoSorb during CABG surgery
  • Overall, severe bleeding according to the Universal Definition of Perioperative Bleeding criteria (UDPB ≥ 3) occurred in 9.8% of patients
  • In a subgroup analysis, the study population was divided into 2 groups. Group 1 comprised patients operated <24 hours from last ticagrelor dose (n=61, mean time 12.6 ± 6.5 hours) and Group 2 comprised patients operated more than 24 but less than 72 hours from last dose (n=41, mean time 37.2 ± 10.1 hours). Demographics were similar between the two groups, however, Group 1 patients had significantly higher perioperative risk compared with Group 2 patients based upon the more frequent need for more hazardous emergency surgery (66.1% vs. 12.2%, p<0.001) and the higher baseline predicted surgical risk according to the standardized EuroScore II score (4.2 vs. 1.7, p=0.006). Expectedly, higher risk patients in Group 1 had a higher rate of severe bleeding compared with Group 2 patients (14.8% vs. 2.4%)
  • To provide historical context to these results, Professor Storey presented published results from the European Multicenter Registry on Coronary Artery Bypass Grafting (E-CABG) reporting postoperative UDPB ≥ 3 bleeding rates in patients on ticagrelor undergoing CABG surgery (without CytoSorb) within 24 hours from the last dose of 26.6% and in patients operated between 24 and 72 hours from last dose of 14.8%, both higher than what was observed in the STAR Registry when intraoperative CytoSorb was used in similar patients

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