Septic shock and the underlying dysregulated inflammatory host-response remain major contributors to mortality in critically ill patients. In contrast to classic hemofiltration strategies, cytokine adsorption through bulk removal of cytokines has been postulated to reestablish inflammatory homeostasis, representing an attractive approach to the treatment of septic shock. Nonetheless, most evidence to date is of descriptive or ambivalent character and cytokine adsorption in severe, refractory septic shock is largely unexplored