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The current landscape of in situ and ex situ machine perfusion utilization for liver grafts from cardiac donation after circulatory…

Abstract Donation after circulatory death (DCD) is driving the increase in deceased organ donors in the United States. Normothermic regional perfusion (NRP) and ex situ machine perfusion (es-MP) have been..

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The ProtekDuo Cannula for Venopulmonary ECMO as Bridge to Lung Transplantation: A Single Center Case Series

Abstract Venovenous extracorporeal membrane oxygenation is the most commonly used mode of support in pre-lung transplant recipients. In patients who experience right ventricular dysfunction, venopulmonary ECMO is an excellent option..

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Veno-venous extracorporeal membrane oxygenation exacerbates lung ischaemia–reperfusion injury in a rat model

Abstract OBJECTIVES Although lung transplantation has experienced great development in the past decades, the survival rate remains low, and lung ischaemia–reperfusion injury during transplantation is a major cause of primary..

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Bloodless lung transplantation: Comparison between 2 central venoarterial extracorporeal membrane oxygenation anticoagulation strategies and their impact on lung transplant outcomes

Abstract Objective To report differences between 2 anticoagulation protocols during venoarterial extracorporeal membrane oxygenation (VA-ECMO) intraoperative support and their effects on outcomes after lung transplantation. Methods We performed a retrospective..

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Deep insight into cytokine storm: from pathogenesis to treatment

Abstract Cytokine storm (CS) is a severe systemic inflammatory syndrome characterized by the excessive activation of immune cells and a significant increase in circulating levels of cytokines. This pathological process..

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Exploring the influence of extra-corporeal membrane oxygenation (ECMO) support on neurodevelopmental outcomes in paediatric cardiac patients: a systematic review

Abstract Background:Mechanical circulatory support, and specifically extra-corporeal membrane oxygenation, plays a critical role in managing paediatric cardiac patients with severe heart failure. Whilst these technologies are vital for bridging patients..

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A Year of Advances in Cardiac Surgery, Transplantation, and Anesthetic Management

Introduction Superlatives and acronyms abound in this year’s edition of annual noteworthy literature for Seminars in Cardiothoracic and Vascular Anesthesia. By the numbers, over 22 000 publications from 2024 were screened, and approximately..

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Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest

Abstract When conventional cardiopulmonary resuscitation (CCPR) cannot restore spontaneous circulation, the initiation of venoarterial extracorporeal membrane oxygenation during refractory cardiac arrest—known as extracorporeal CPR (ECPR)—might restore circulation and adequate tissue..

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Goodnight Moon: The (not so) mystical effect of folklore and superstitions on cardiac transplantation

Abstract Background The effect of Friday the 13th and Full Moons on cardiac transplantation is unknown. We investigated the impact of these superstitious events on recipient and donor qualities, complications,..

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The dosage makes the poison – ECMO support considerations in poisoning

Abstract Acute poisoning may lead to life-threatening conditions that require advanced life support, such as extracorporeal membrane oxygenation (ECMO). Data about the use of ECMO in intoxications and overdose are..

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Take a Deep Breath: Operating Room Extubation After Bilateral Lung Transplantation on Venoarterial Extracorporeal Membrane Oxygenation

Abstract IN PATIENTS UNDERGOING bilateral lung transplant (BLT), the use of planned intra- and postoperative venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasing. It has become the standard practice in many..

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Cholesterol levels as a predictive marker for ICU survival in patients with cardiogenic shock supported by VenoArterial ExtraCorporeal membrane oxygenation

Abstract Background Veno-Arterial Extracorporeal Life Support (VA ECMO) is a critical intervention for patients with cardiogenic shock, serving as bridge to recovery, transplantation, or long-term therapies. The complexity of VA..

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The hidden dangers of electronic cigarettes: e-cigarette, or vaping, product-use associated lung injury requiring extracorporeal membrane oxygenation

Abstract In recent decades, multiple efforts have been made to reduce population exposure to cigarettes, given that smoking is responsible for thousands of deaths annually. These actions have been effective,..

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Thirty Years of Perfusion Licensure in the United States: Exploring Current Concepts and Developing New Strategies for the Future

Abstract Over the past 30 years, licensure and certification requirements for cardiovascular perfusionists have varied considerably in the United States. In addition to intraoperative perfusion for cardiac surgery, the role..

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Extracorporeal membrane oxygenation as a bridge to thoracic multiorgan transplantation

Abstract Background Extracorporeal membrane oxygenation (ECMO) has emerged as a crucial tool in the care of patients with multiorgan failure and is increasingly utilized as a bridge to transplantation. While..

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Does Levosimendan hasten veno-arterial ECMO weaning? A propensity score matching analysis

Abstract Background Preliminary evidence from small, single-center studies suggests levosimendan may improve the likelihood of successful venoarterial extracorporeal membrane oxygenation (VA-ECMO) weaning in patients with cardiogenic shock. However, the literature..

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Brief hypothermic oxygenated perfusion provides cardioprotection in a pig model of donation after circulatory death

Abstract OBJECTIVES Donation after circulatory death provides excellent patient outcomes in heart transplantation; however, warm ischaemic graft damage remains a concern. We have reported that a brief period of hypothermic..

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Outcomes after lung transplantation performed using elective cardiopulmonary bypass: A single-center experience

Abstract Background There remains significant variability in the use of intraoperative mechanical circulatory support in lung transplantation. This report details our outcomes using elective cardiopulmonary bypass (CPB) in lung transplantation...

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Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry

Abstract BACKGROUND: A preservation system, the Organ Care System (OCS; TransMedics) uses normothermic pulsatile perfusion during organ transport for heart transplantation. This system has demonstrated favorable outcomes in hearts recovered..

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Practical Considerations for Extracorporeal Membrane Oxygenation Use During Orthotopic Liver Transplantation

Abstract Patients undergoing liver transplantation infrequently require extracorporeal membrane oxygenation (ECMO) support. However, when ECMO is required in the peritransplant period, several key considerations are required to maximize the efficacy..

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Recent Advances and Future Directions in Extracorporeal Carbon Dioxide Removal

Abstract Extracorporeal carbon dioxide removal (ECCO2R) is an emerging technique designed to reduce carbon dioxide (CO2) levels in venous blood while enabling lung-protective ventilation or alleviating the work of breathing...

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Ethical Issues in Normothermic Regional Perfusion in Controlled Organ Donation After Determination of Death by Circulatory Criteria: A Scoping Review

Abstract Normothermic regional perfusion (NRP) is a surgical technique that can improve the quality and number of organs recovered for donation after the determination of death by circulatory criteria. Despite..

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Normothermic Regional Perfusion in Controlled Donation After the Circulatory Determination of Death: Understanding Where the Benefit Lies

Abstract Controlled donation after the circulatory determination of death (cDCDD) has emerged as a strategy to increase the availability of organs for clinical use. Traditionally, organs from cDCDD donors have..

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Oxygen delivery and carbon dioxide removal on venovenous extracorporeal membrane oxygenation

Abstract Purpose of review  Venovenous extracorporeal membrane oxygenation (VV-ECMO) provides gas exchange for patients with advanced respiratory failure who cannot maintain adequate oxygenation or carbon dioxide (CO2) clearance through conventional..

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Implementation of a Multidisciplinary Team for Initiation of Extracorporeal Cardiopulmonary Resuscitation in Patients Presenting After Out-of-hospital Cardiac Arrest

Abstract Objectives Patents with out-of-hospital cardiac arrest (OHCA) are at high risk of death or poor neurologic recovery if spontaneous circulation is not rapidly restored. Emergent mechanical circulatory support with..

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Survey of Extracorporeal Life Support Application in Lung Transplantation

Abstract Introduction Lung transplantation has been evolving since its inception in 1963. Over recent years, literature has suggested a shift in the perioperative strategy of mechanical support toward extracorporeal membrane..

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Parallel Venovenous Extracorporeal Membrane Oxygenation Circuits During Bridge-to-Lung Transplantation

Abstract Venovenous (VV) extracorporeal membrane oxygenation (ECMO) supports end-organ oxygen delivery in patients with refractory respiratory failure. Physical therapy (PT) while on ECMO provides conceptual benefits of strength and conditioning...

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The first case of central Y–Y extra-corporeal membrane oxygenation system in a pediatric patient

Abstract The mechanical circulatory support (MCS) for pediatric patients with severe acute heart failure and poor pulmonary conditions is challenging. Herein, we report the first pediatric case of successfully treated..

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The superiority of veno-arterial over veno-venous extracorporeal membrane oxygenation for operative support of lung transplantation

Abstract Background Veno-arterial (V-A) and veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) are crucial support modalities during lung transplantation, yet their comparative effectiveness remains unclear. Methods We conducted an 8-year retrospective..

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Extracorporeal membrane oxygenation for adults with respiratory failure secondary to cardiorespiratory disease: evolving indications and clinical practice

Abstract Extracorporeal membrane oxygenation (ECMO) can support patients with severe cardiorespiratory failure presenting with hypoxia who would otherwise have not survived. Patient selection for ECMO is challenging and relies on..

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