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How I Do It: Donation After Circulatory Death With Normothermic Regional Perfusion in Small Babies

Abstract Background: The gold standard for treatment of patients with end-stage heart failure remains . Time spent on the active waiting list, notably for  patients, contributes to alarmingly high mortality. Donation after..

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Description and Management of Cardiac Arrests in Congenital Cardiac Patients Undergoing Cardiac Surgery, Cardiac Catheterization, and Cardiac Imaging

Abstract Objective To describe cardiac arrest during anesthesia care provided by a pediatric cardiac anesthesiologist in patients with congenital heart disease and identify predictors of outcome. Design Retrospective chart review...

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“When I walk away and wonder, did I make the best decision?”: A decisional needs assessment among providers involved in…

Abstract Purpose Extracorporeal cardiopulmonary resuscitation (ECPR) is an advanced resuscitation therapy for cardiopulmonary arrest refractory to standard CPR. ECPR treatment recommendations are not supported by strong evidence, and institutional criteria..

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Inflammatory Markers During Extracorporeal Membrane Oxygenation in Neonates With Congenital Diaphragmatic Hernia

Abstract This study aimed to assess whether the proinflammatory markers procalcitonin (PCT), C-reactive protein (CRP), or interleukin 6 (IL-6) are associated with mortality in neonates with congenital diaphragmatic hernia (CDH)..

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Everolimus and Low-Dose Tacrolimus After Heart Transplant in Children

Abstract Importance  Studies suggest that everolimus may reduce the risk of rejection, cardiac allograft vasculopathy (CAV), chronic kidney disease (CKD), and cytomegalovirus (CMV) after heart transplant. Everolimus use is controversial because..

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Nutritional support in pediatric patients with extracorporeal membrane oxygenation: new insights

Abstract Nutritional support in pediatric patients receiving extracorporeal membrane oxygenation (ECMO) therapy is controversial. Although ECMO is increasingly used in pediatric intensive care units, there is no consensus on the..

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Relationship between intraoperative blood pressure variability and postoperative acute kidney injury in pediatric cardiac surgery

Abstract Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is a notably common complication in pediatrics, with an incidence rate ranging from 15 to 64%. This rate is significantly higher than..

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Temporal trends and risk factors for bleeding and thrombosis in pediatric ECMO: A multicenter cohort study

Abstract Introduction Bleeding and thrombosis are major causes of morbidity and mortality in pediatric extracorporeal membrane oxygenation (ECMO), yet their evolving, time-dependent risks remain poorly defined. This study evaluated clinical..

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Large Single-Center Experience With Extubation During Neonatal and Pediatric Extracorporeal Membrane Oxygenation

Abstract Extubation of select neonatal and pediatric patients supported with extracorporeal membrane oxygenation (ECMO) may avoid ventilator-induced lung injury, decrease neurosedative exposure, and improve rehabilitation. A single-center retrospective cohort study..

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Review of Current Normothermic Regional Perfusion Practice in Pediatric Cardiac Donation

Abstract Background Cardiac allotransplantation is the optimal treatment for end-stage heart failure. However, organ supply remains the principal issue affecting patients. Pediatric patients present unique challenges resulting in long wait-list..

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Assessing the Efficacy of Pathogen-Reduced Platelet Transfusions for Hemostasis in Children Undergoing Cardiopulmonary Bypass Surgery

Abstract Background Children undergoing cardiopulmonary bypass (CPB) surgery are vulnerable to bleeding and often require transfusions. Pathogen-reduced (PR) platelets may reduce microbial contamination but are associated with decreased platelet count..

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Blood Transfusions are Associated With Prolonged Mechanical Ventilation Following Cardiac Surgery in Neonates

Abstract Background: To investigate the factors that influence blood transfusions after neonatal cardiac surgery and their association with prolonged mechanical ventilation (PMV) to provide a basis for optimizing blood transfusion..

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Is Cardiac Surgery Safe During GenAI exceeds clinical experts in predicting acute kidney injury following paediatric cardiopulmonary bypassPregnancy?

Abstract The emergence of large language models (LLMs) opens new horizons to leverage, often unused, information in clinical text. Our study aims to capitalise on this new potential. Specifically, we..

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Impact of acute kidney injury and dysnatremia on length of stay in infants after cardiac surgery

Abstract Background Acute kidney injury (AKI) and dysnatremia following pediatric cardiac surgery are common conditions associated with worse outcomes. While the multifactorial etiology of AKI is well-known, the role of..

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Modified ultrafiltration warming technology in pediatric congenital heart disease surgery: A case‒control study

Abstract Background To evaluate the effect and safety of modified ultrafiltration warming technology during pediatric congenital heart disease (CHD) surgery. Methods A retrospective analysis included 68 children (<1 year) who..

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Successful Treatment of Extracorporeal Membrane Oxygenation Induced Digital Ischemia in Infants Using Botulinum Toxin Type A

Abstract Digital ischemia following extracorporeal membrane oxygenation (ECMO) therapy is a known complication with potential devastating long-term sequela. Onabotulinum toxin type A (BTX-A) has been demonstrated to be effective for..

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On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death

Abstract Cardiac allotransplantation is warranted in children with end-stage heart failure or irreparable congenital heart disease. A dearth of organs for transplantation has contributed to long wait-list times and resultant..

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Is hyperoxia in early pediatric veno-veno extracorporeal life support associated with mortality?

Abstract Background: Data is limited regarding the effects of supraphysiologic blood oxygen tension (hyperoxia) in patients requiring extracorporeal life support (ECLS). We sought to evaluate the association between hyperoxia and..

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Comprehensive secondary analysis of thrombotic events in pediatric patients receiving extracorporeal membrane oxygenation: A prospective cohort study

Abstract Introduction This study aims to describe laboratory and clinical factors associated with thrombotic events during prolonged pediatric extracorporeal membrane oxygenation. Methods A secondary analysis of a multi-center prospective study..

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Evaluation of Intraoperative Bivalirudin Anticoagulation in Neonates and Infants Undergoing Arterial Switch Operation on Integrated ECMO-CPB Circuit: A Prospective Study

Abstract Objectives To ascertain the dosage of bivalirudin in neonates and infants undergoing arterial switch operation on integrated extracorporeal membrane oxygenation–cardiopulmonary bypass (CPB) circuit. Design Pilot study. Setting A tertiary..

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Hyperlactatemia in Critically Ill Children: Modeling Early Recovery Kinetics After Initiation of Extracorporeal Membrane Oxygenation

Abstract Objectives:  Blood lactate concentration ([Lac]b) reflects the balance among production, clearance (Cl[Lac]), and volume of distribution. We have observed dramatic improvement in [Lac]b in critically ill patients after starting support..

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Hospital-acquired infections in neonatal ECMO patients: a systematic review and meta-analysis

Abstract To evaluate the impact of hospital-acquired infections ( HAIs ) on the prognosis of neonates treated with extracorporeal membrane oxygenation (ECMO) and analyzing related prognostic indicators, we conducted a..

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ECMO Use in Neonates with Hypoxic–Ischemic Encephalopathy

Abstract Extracorporeal membrane oxygenation (ECMO) is an important rescue strategy for neonates with severe cardiorespiratory failure, yet its role in the management of hypoxic–ischemic encephalopathy (HIE) remains subject to debate...

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Cardiac surgery-associated acute kidney injury in neonatal Norwood procedure: incidence, risk factors and impact on mortality and outcomes

Abstract OBJECTIVES Acute kidney injury commonly complicates congenital heart surgery with cardiopulmonary bypass, increasing morbidity and mortality. This study aimed to evaluate risk factors for postoperative acute kidney injury and..

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Intraoperative cell salvage utilization for blood conservation during pediatric and adult spinal surgery: a state-of-the-art systematic review

Abstract Purpose The purpose of this systematic review was to identify the efficacy of cell salvage in adult and pediatric spinal surgery. Methods A comprehensive systematic review of four biomedical..

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A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up – towards an international prognostication guideline

Abstract Aims Pediatric cardiac arrest is associated with high mortality and significant morbidity among survivors. International guidelines for prognostication remain limited due to small heterogeneous patient populations, variable post-return of..

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Functional Status Trends for Adults and Children on Extracorporeal Membrane Oxygenation at Time of Lung Transplantation

Abstract Poor or worsening functional status of lung transplant (LTx) candidates is a key risk factor for waitlist and post-transplant mortality. As more critically ill adults and children are listed..

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Assembling, Priming, and Storing Circuits for Pediatric and Neonatal Extracorporeal Membrane Oxygenation

Abstract The storing of dry-assembled and primed extracorporeal membrane oxygenation (ECMO) circuits is common practice and endorsed by the Extracorporeal Life Support Organization (ELSO) for up to 30 days. We..

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Ductus Arteriosus Patency for the Hemodynamic Management of Newborns With Pulmonary Hypertension on Veno-Venous Extracorporeal Membrane Oxygenation

Abstract In neonates with pulmonary hypertension (PH) supported on veno-venous extracorporeal membrane oxygenation (VV-ECMO), keeping the ductus arteriosus (DA) open ensures a high cardiac output of well-oxygenated blood through the..

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Prophylactic corticosteroids in neonatal cardiac surgeries using cardiopulmonary bypass: a systematic review and meta-analysis

Abstract Purpose Neonates undergoing cardiopulmonary bypass (CPB) are at a high risk of a systemic inflammatory response leading to cardiac, respiratory, and renal dysfunction due to their small body size..

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