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Outcomes in Obese Are Comparable to Non-Obese Patients: A Propensity Matched Cohort Study

Abstract Introduction: Obesity, defined as a body mass index ≥ 40 kg/m2, was considered a relative contraindication to cannulation for extra-corporeal membrane oxygenation (ECMO) during the coronavirus pandemic. While body habitus can..

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A safe and effective method for percutaneous, awake, bedside decannulation of peripheral VA ECMO using vascular closure devices: a case…

Abstract Decannulation of patients on peripheral veno-arterial extracorporeal membrane oxygenation (VA ECMO) typically involves femoral arterial cutdown and surgical arteriotomy closure in an operating room under general anesthesia. However, this..

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Levosimendan in extracorporeal membrane oxygenation in refractory cardiac arrest

Abstract Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) can re-establish tissue perfusion in refractory cardiac arrest requiring cardiopulmonary resuscitation (CPR). Levosimendan showed potential benefit in VA-ECMO weaning and mortality but was not..

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How I manage differential gas exchange in peripheral venoarterial extracorporeal membrane oxygenation

Abstract Dual circulation is a common but underrecognized physiological occurrence associated with peripheral venoarterial extracorporeal membrane oxygenation (ECMO). Competitive flow will develop between blood ejected from the heart and blood..

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Radiation Exposure in Extracorporeal Life Support

Abstract Extracorporeal membrane oxygenation (ECMO) exposes patients to multiple radiologic studies. We hypothesized ECMO patients endure radiation exposure in excess of the International Commission of Radiological Protection (ICRP) recommendations of..

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Prevalence of FXII-Deficiency and Its Relevance to Monitoring Anticoagulation in Adults Receiving Extracorporeal Membrane Oxygenation

Abstract During extracorporeal membrane oxygenation (ECMO) blood is exposed to artificial surfaces, resulting in contact activation of the intrinsic coagulation pathway initiated by coagulation factor XII (FXII). Little is known..

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Age and associated outcomes among patients receiving venoarterial extracorporeal membrane oxygenation–analysis of the Extracorporeal Life Support Organization registry

Abstract Purpose Venoarterial extracorporeal membrane oxygenation (V-A ECMO) can be used to support severely ill patients with cardiogenic shock. While age is commonly used in patient selection, little is known..

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Anticoagulation strategies in COVID-19 infected patients receiving ECMO support

Abstract Background: Hospitalized COVID-19 patients with hypoxemic respiratory failure may deteriorate despite invasive mechanical ventilation and thus require extracorporeal membrane oxygenation (ECMO) support. Unfractionated heparin (UFH) is the antithrombotic of..

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Understanding lactate and its clearance during extracorporeal membrane oxygenation for supporting refractory cardiogenic shock patients

Abstract The recent study by Scolari et al. [] entitled ‘Association between serum lactate levels and mortality in patients with cardiogenic shock receiving mechanical circulatory support: a multicenter retrospective cohort..

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Integral assessment of gas exchange during veno-arterial ECMO: accuracy and precision of a modified Fick principle in a porcine model

Abstract Assessment of native cardiac output during extracorporeal circulation is challenging. We assessed a modified Fick principle under conditions such as dead space and shunt in 13 anesthetized swine undergoing..

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Albumin Infusion Reduces Fluid Loading for Postresuscitation Syndrome in a Pig Model of Refractory Cardiac Arrest Resuscitated With Venoarterial Extra…

Abstract Hemodynamic instability in postresuscitation syndrome worsens survival and neurological outcomes. Venoarterial extracorporeal membrane oxygenation (VA ECMO) for refractory cardiac arrest might improve outcomes. Hemodynamical support under VA ECMO relies..

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Concomitant Use of VA-ECMO and Impella Support for Cardiogenic Shock

Abstract Background: VA-ECMO with concomitant Impella support (ECpella) is an emerging treatment modality for cardiogenic shock (CS). Survival outcomes by CS etiology with ECpella support have not been well-described. Methods: This study..

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Predictors of Survival Outcomes and Discharge Location following VA-ECMO

Abstract Background: Mortality and complication rates remain high with VA-ECMO. Understanding risk factors for mortality and post-ECMO functional status may aid conversations about prognosis. Methods: ELSO Registry data for adults supported with..

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An emerging complementary strategy to treat acute heart failure (AHF) and cardiogenic shock (CS): the first clinical trial in China…

Abstract Mechanical circulatory support (MCS) is an emerging therapy for acute heart failure (AHF) or cardiogenic shock (CS) patients unresponsive to medicinal treatment. In China, common treatments using short-term MCS..

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Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial

Abstract BACKGROUND: Although venoarterial extracorporeal membrane oxygenation (VA-ECMO) is beneficial for the treatment of profound cardiogenic shock, peripheral VA-ECMO cannulation can increase left ventricular afterload, thus compromising myocardial recovery. We..

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The role of ECMO support in airway procedures

Abstract The role of ECMO support in airway procedures

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Advanced hemocompatible polyethersulfone composite artificial lung membrane with efficient CO2/O2 exchange channel constructed by modified carbon nanotubes network

Abstract Artificial lung membranes as the core module of the extracorporeal membrane oxygenation technology (ECMO) execute the function of extracorporeal blood-gas barrier accomplishing CO2/O2 exchange with blood. However, the unsatisfactory hemocompatibility..

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Expert consensus on training and accreditation for extracorporeal cardiopulmonary resuscitation an international, multidisciplinary modified Delphi Study

Abstract Background A multidisciplinary group of stakeholders were used to identify: (1) the core competencies of a training program required to perform in-hospital  initiation (2) additional competencies required to perform pre-hospital  initiation..

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Outcomes of Extracorporeal Life Support Utilization for Pediatric Patients With COVID-19 Infections

Abstract Outcomes of pediatric patients who received extracorporeal life support (ECLS) for COVID-19 remain poorly described. The aim of this multi-institutional retrospective observational study was to evaluate these outcomes and..

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Outcomes in Obese Adult Veno-Venous Extracorporeal Membrane Oxygenation: A Systematic Review

Abstract Obesity is associated with an overall increased risk of morbidity and mortality. However, in patients with critical illness, sepsis, and acute respiratory distress syndrome, obesity may be protective, termed..

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ECMO for Premature Neonates- Are we there yet?

Abstract Despite ECMO being a well-accepted and established life-saving support for newborns, prematurity (<34 weeks of gestation) and low birth weight <2.0 kg are still considered relative contraindications due to..

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Lower Oxygen Tension and Intracranial Hemorrhage in Veno-venous Extracorporeal Membrane Oxygenation

Abstract Introduction and Methods We examined the relationship between 24-h pre- and post-cannulation arterial oxygen tension (PaO2) and arterial carbon dioxide tension (PaCO2) and subsequent acute brain injury (ABI) in..

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Use of Extracorporeal Membrane Oxygenation for Primary Graft Dysfunction After Cardiac Transplantation: Results of an A Priori Ventless Approach

Abstract Primary graft dysfunction (PGD) after cardiac transplantation is a devastating complication with increasing frequency lately in the setting of donation after circulatory death (DCD). Severe PGD is commonly treated..

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Monitoring Renal Oximetry in Donors Undergoing Normothermic Regional Perfusion After Circulatory Determination of Death

Abstract Regional tissue oxygen saturation (rSO2) monitoring through near-infrared spectroscopy (NIRS) has been reported as a non-invasive strategy to estimate the adequacy of matching between oxygen delivery (DO2) and oxygen..

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Extracorporeal Membrane Oxygenation Physiological Factors Influence Pulse Oximetry and Arterial Oxygen Saturation Discrepancies

Abstract Background  strategy, vasopressors, and hemolysis are important physiological factors that influence  in  (ECMO). We hypothesized these factors influence the discrepancy between  measured by  (Spo2) and  (Sao2)  on ECMO. Methods We retrospectively analyzed adults (aged ≥18..

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Multicenter Assessment of a Novel ECMO Cannulation Simulator Using a Standardized Procedural Checklist

Abstract Background: Venoarterial extracorporeal membrane oxygenation (VA ECMO) is an emergency procedure performed across various specialties. These conditions present barriers to education and assessment of competency. Checklists and simulation may be..

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Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation

Abstract Background  (FXII) is a multifunctional  capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in  (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not..

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Effects of different positive end-expiratory pressure titration strategies on mechanical power during ultraprotective ventilation in ARDS patients treated with veno-venous…

Abstract Purpose Ultraprotective ventilation in  (ARDS) patients with veno-venous  (VV ECMO) reduces mechanical power (MP) through changes in positive end-expiratory pressure (PEEP); however, the optimal approach to titrate PEEP is unknown. This..

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Interprofessional Extracorporeal Membrane Oxygenation Cardiopulmonary Resuscitation Simulations Aimed at Decreasing Actual Cannulation Times: A Longitudinal Study

Abstract Background: Since 2013, the cardiac intensive care unit (CICU) at Children's National has conducted annual extracorporeal membrane oxygenation cardiopulmonary resuscitation (ECPR) simulations that focus on team dynamics, room setup, and..

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Extracorporeal Life Support in Infarct-Related Cardiogenic Shock

Abstract BACKGROUND Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack of evidence regarding its effect on mortality. METHODS In this multicenter..

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