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Conversion From Venovenous to Venoarterial or Hybrid Extracorporeal Membrane Oxygenation: Analysis From the Extracorporeal Life Support Organization Registry

Abstract Objectives:  Venovenous extracorporeal membrane oxygenation (ECMO) represents a standard and well-accepted modality of treating patients with refractory respiratory failure. Nevertheless, some patients might develop refractory hypoxemia, hemodynamic compromise or..

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Effect of prone positioning on pathophysiology and lung histopathology during VV-ECMO in severe ARDS: an experimental animal study

Abstract Background: Prone positioning improves survival in patients with acute respiratory distress syndrome (ARDS) by reducing ventilator-induced lung injury and enhancing ventilation–perfusion matching. Whether these physiological benefits translate to patients..

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Investigating biomarkers associated with mortality in patients receiving VA-ECMO for cardiogenic shock: a systematic review

Abstract Context: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-sustaining therapy for severe refractory cardiogenic shock. Although VA-ECMO provides various degrees of cardiopulmonary support, mortality rates remain high. Serum biomarkers have..

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A consensus of international experts on definition, sampling, treatment, and prevention of peripheral extracorporeal membrane oxygenation cannula-site infection obtained by…

Abstract Background: Nosocomial infections are common in patients receiving extracorporeal membrane oxygenation (ECMO), with ECMO cannula‑site infections (ECMO‑CSI) being the most frequent infections directly related to the ECMO run. These..

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The importance of early veno-arterial extracorporeal membrane oxygenation in the management of amniotic fluid embolism complicated by cardiac arrest: a…

Abstract Background Amniotic fluid embolism (AFE) with cardiac arrest is an obstetric emergency with an exceedingly high maternal mortality. Early application of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may provide essential..

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A Contemporary Guide of Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock

Abstract Managing refractory cardiogenic shock is individualized, with few aspects considered routine or universally contraindicated. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary mechanical circulatory support strategy, providing hemodynamic stabilization..

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Incidence of Healthcare-Associated Infections in Patients on Extracorporeal Membrane Oxygenation Secondary to Respiratory or Cardiac Failure: A Retrospective Cohort Study

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a life support technique used in patients with respiratory or cardiac failure. Despite the increased use of ECMO, the incidence and risk factors..

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Increasing Anticoagulation Intensity in the Oxygenator During Flow Reduction Trials in Venoarterial Extracorporeal Membrane Oxygenation

Abstract Anticoagulation is mandatory during venoarterial extracorporeal membrane oxygenation (V-A ECMO) flow reduction trials with very low blood flow. Anticoagulation in the ECMO circuit might be intensified with less effect..

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Training of Emergency Medicine Residents to Initiate Extracorporeal Membrane Oxygenation Cardiopulmonary Resuscitation (ECPR)

Abstract Background The objective of our study was to evaluate the ability of Emergency Medicine (EM) physicians who have completed an accelerated extracorporeal membrane oxygenation (ECMO) course and mannequin training..

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Predictors of VV-ECMO weaning safety: longitudinal ventilatory ratio assessment during sweep gas off trials, a retrospective cohort study

Abstract Background Separation from venovenous extracorporeal membrane oxygenation (VV-ECMO) is a pivotal transition for patients with acute respiratory distress syndrome (ARDS). Impaired alveolar ventilation more so than oxygenation may be..

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Trauma Extracorporeal Membrane Oxygenation in Argentina: Complications, Mortality, and Long-term Outcomes

Abstract Extracorporeal membrane oxygenation (ECMO) for trauma is underreported in Latin America. We conducted a cohort study in four centers from Argentina (2015–2024), including all adults with polytrauma (defined as..

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Extracorporeal membrane oxygenation in a low-volume whole nation cardiothoracic centre: short- and long-term mortality, survivors` quality of life and symptoms…

Abstract Background For over three decades ECMO-treatment has been provided in our low-volume nationwide cardiothoracic centre in Iceland. This research aims to examine both the short- and long-term results of..

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Evolution of extracorporeal membrane oxygenation: historical milestones and advanced developments

Abstract Extracorporeal membrane oxygenation (ECMO) has a history that is a testament to the pioneering spirit of medical innovators. It is intricately linked with the development of cardiopulmonary bypass (CPB)..

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Percutaneous Postclosure vs Femoral Arterial Cutdown for Venoarterial Extracorporeal Membrane Cannulation Sites

Abstract Background This study sought to examine the outcomes of percutaneous postclosure of large-bore femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) cannulas compared with a traditional open cutdown technique. Methods Between..

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Multiple faces of equity in extracorporeal membrane oxygenation

Abstract Health care is not a luxury in the sense of being an enjoyment or an unnecessary indulgence, but inequality and inaccessibility can make certain services seem like luxuries. Health..

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ISHLT Consensus Statement on the Perioperative use of ECLS in Lung Transplantation: Part III: Postoperative Considerations

Abstract The use of extracorporeal life support (ECLS) throughout the perioperative phase of lung transplantation requires nuanced planning and execution by an integrated team of multidisciplinary experts. To date, no..

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Survival on the clock: rethinking where and how we deliver ECPR

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) is the only therapy capable of rescuing patients from refractory cardiac arrest, but its effectiveness is critically dependent on time to reperfusion. The system proposed..

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Impact of rhythm changes during CPR on ECPR outcomes: an ELSO Registry study

Abstract Background Cardiac rhythm is a well-established prognostic factor in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR); however, existing evidence is primarily limited to small, single-center studies. This study aimed to..

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Outcomes of Venopulmonary Extracorporeal Membrane Oxygenation Conversion in Patients With Severe Respiratory Failure on Venovenous Support

Abstract Severe respiratory failure is frequently complicated by right ventricular dysfunction (RVD), which occurs in 20–50% of cases. In patients on venovenous extracorporeal membrane oxygenation (VV ECMO) with refractory RVD,..

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Antimicrobial pharmacokinetics and stewardship in critically Ill adult patients receiving ECMO: Challenges, evidence, and future directions

Abstract Infection is a common indication and complication for extracorporeal membrane oxygenation (ECMO), and adult ECMO recipients face increased nosocomial infection risk. Effective antimicrobial dosing in these patients remains difficult..

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ECMO to CPB: A single circuit approach

Abstract Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and cardiopulmonary bypass (CPB) are used during pediatric heart surgery to provide cardiopulmonary support to patients as they undergo and recover from surgical..

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Nitric oxide delivery into the sweep flow of ECMO systems: Technical challenges and solutions

Abstract Sweep gas nitric oxide (sNO) is emerging as an adjunctive therapy, which may have positive impacts on thrombosis and inflammation during ECMO treatment. sNO is administered to the gas..

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Call for Standardized Intraoperative Weaning and Decannulation Practices in Venoarterial ECMO: Need for Consensus and Clinical Guidelines

Abstract Assessment of readiness for venoarterial extracorporeal membrane oxygenation (VA ECMO) weaning relies on hemodynamic and metabolic parameters of cardiac and respiratory functions. Lactate clearance, inotropic support, and echocardiographic criteria,..

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Modified cardiac power output as a marker for left ventricular recovery during V-A ECMO

Abstract Dear Editor, The timely liberation of cardiogenic shock (CS) patients from veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is crucial to reduce device  complications, although the predictor of weaning is..

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Pharmacological Research Agenda on Adult Extracorporeal Membrane Oxygenation Using the Delphi Method: A Position Paper of the Extracorporeal Membrane Oxygenation…

Abstract OBJECTIVES:  Extracorporeal membrane oxygenation (ECMO) is a critical intervention for patients with severe cardiac or respiratory failure. However, pharmacological management for ECMO-supported patients presents unique challenges due to alterations..

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Neuromonitoring Techniques in ECMO

Abstract Extracorporeal membrane oxygenation (ECMO) is a critical life-support therapy for patients with severe cardiac and/or respiratory failure, but it carries a significant risk of neurological complications. This narrative review..

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Development and application of a novel framework for mobility & rehabilitation under support of extracorporeal life support: The MUSECLS framework

Abstract Introduction Mobility and rehabilitation for patients supported on extracorporeal life support (ECLS) are high-risk and resource-intensive endeavors that currently lack a standardized framework to guide comprehensive program development. This..

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Clinical Guideline for Treating Acute Respiratory Insufficiency with Invasive Ventilation and Extracorporeal Membrane Oxygenation: Updated Evidence- Based Recommendations for Choosing…

Abstract Invasive mechanical ventilation remains a cornerstone in the treatment of critically ill patients suffering from acute respiratory failure, providing life-sustaining gas exchange while necessitating careful selection of modes and..

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Effect of artificial intelligence in extracorporeal membrane oxygenation: a systematic review and meta-analysis

Abstract Objectives To evaluate the effectiveness of Artificial Intelligence (AI) in improving clinical outcomes in Extracorporeal Membrane Oxygenation (ECMO) management, focusing on ECMO initiation, prognosis, and complications. Methods A meta-analysis following..

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Optimizing IABP–patient interaction in VA-ECMO via transcranial doppler

Abstract Background Patients supported with veno-arterial extracorporeal membrane oxygenation may receive an intra-aortic balloon pump to reduce left ventricular afterload and improve aortic diastolic pressure. However, the effect of this..

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