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Simple and reliable method for predicting extracorporeal membrane oxygenation flow rates and circuit pressures

Abstract Background Venovenous extracorporeal membrane oxygenation (ECMO) is essential for patients with severe respiratory failure who do not respond to conventional mechanical ventilation. Adequate ECMO flow and safe circuit pressure..

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Noninvasive Predictive Model for Rapid Hemodynamic Optimization During Mechanical Circulatory Support

Abstract Mechanical circulatory support (MCS) devices are standard therapy for advanced heart failure, but modern systems lack standardized methods for setting critical parameters such as rotational speed and flow rate...

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Initiating Cardiopulmonary Bypass Using a Dry Venous Line: Implications and Analysis

Abstract Cardiopulmonary bypass (CPB) is an essential component of modern cardiac surgery, allowing surgeons to temporarily replace heart and lung function during complex procedures. One important technical aspect of CPB..

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Integration Health Guides Hospitals in Advanced Circulatory Support Through ECMO and Perfusion Educational Resources

Abstract Hospitals seeking to implement complex technologies like extracorporeal membrane oxygenation (ECMO) now have practical roadmaps thanks to Integration Health’s effort to provide guidance drawn from decades of clinical and..

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Prolonged Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation in Sheep

Abstract Clinically significant bleeding is a common complication of extracorporeal membrane oxygenation (ECMO), with bleeding observed in upwards of 40% of patients. Bleeding is strongly associated with systemic anticoagulation, which..

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Acellular Hemoglobin Impairs Cardiomyocyte Excitation-Contraction Coupling

Abstract Heart failure is a significant complication of chronic intravascular hemolysis, a condition characterized by red blood cells (RBCs) breakdown, leading to the release of acellular hemoglobin (Hb) and its..

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Balancing flow and filtration: AKI during ECMO

Abstract Acute Kidney Injury (AKI) cannot be viewed as a mere complication in critically ill patients who require extracorporeal membrane oxygenation (ECMO). Rather, it is being increasingly recognized as an..

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Venoarterial Extracorporeal Membrane Oxygenation Drainage Cannula Choice Impacts Flow Dynamics and Thrombosis Risk: A Computational Analysis

Abstract The drainage cannula in a venoarterial extracorporeal membrane oxygenation (VA ECMO) circuit transfers venous blood from the patient to a pump. However, drainage cannulas are prone to thrombosis, leading..

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Net Prolongation of Life in Advanced Heart Failure: An Intentional Strategy of Durable LVAD Therapy Followed by Heart Transplantation

Abstract Heart transplantation (HT) and durable left ventricular assist device (LVAD) support are established surgical treatment options for patients with end-stage systolic heart failure (HF) and/or nonrecoverable cardiogenic shock. HT..

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Effects of mild and moderate hypothermia on renal injury evaluated with neutrophil gelatinase associated lipocalin cystatin C and near infrared…

Abstract Background: The degree of hypothermia during coronary artery bypass grafting (CABG) surgery may affect kidney injury. In this study we compared the effects of mild (MLD) and moderate (MOD) hypothermia..

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Association of VA-ECMO support and long-term quality of life after post-cardiotomy cardiogenic shock: experience from a prospective cohort

Abstract Post-cardiotomy cardiogenic shock (PC-CS) affects 2–6% of cardiac surgery patients. While survival rates keep improving, 40% of intensive care (ICU) survivors experience a “post-intensive care syndrome”, encompassing physical, cognitive,..

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Difficult cannulations in neonatal and pediatric ECMO: Illuminating obstructions to timely therapy

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) provides life-saving support for patients with advanced cardiorespiratory failure, yet unanticipated difficulties with peripheral cannulation can delay therapy. This study describes challenging neonatal and..

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APECx—Anaesthesia, Perfusion and Surgical Practices in Cardiac Surgery: Main Study Protocol of a Modular Multiphase Prospective International Multicentre Observational Study

Abstract The perioperative management in adult cardiac surgery patients remains highly variable across centres and regions. The APECx study (Anaesthesia, Perfusion and surgical practicEs in Cardiac surgery) aims to describe..

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Evidence-based guidelines for the use of extracorporeal membrane oxygenation in Australia and New Zealand using GRADE methodology series part 1:…

Abstract We aim to provide evidence-based clinical practice guidelines for the use of VV ECMO in adult patients across Australia and New Zealand. Developed by a multidisciplinary panel of clinicians..

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Post-operative oxygen delivery and delirium after cardiac surgery with cardiopulmonary bypass: A multisite retrospective cohort study of 1,690 patients

Abstract Introduction Delirium is a common, distressing, and dangerous complication after cardiac surgery with cardiopulmonary bypass (CPB) with few modifiable risk factors. This study aims to determine the association between..

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Stone Heart Syndrome After Aortic Valve Replacement for Severe Aortic Stenosis: A Case Report

Abstract Stone heart syndrome (SHS) is a rare but catastrophic complication of cardiac surgery, characterized by irreversible ischemic myocardial contracture following prolonged global myocardial ischemia, and is almost uniformly fatal..

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A Prospective Analysis of Viscoelastic Assays, Platelet Aggregometry, and Standard Laboratory Tests in Predicting Perioperative Blood Loss in Cardiac Surgery

Abstract Background Postoperative bleeding following cardiopulmonary bypass (CPB) remains a significant challenge. Although viscoelastic testing is increasingly used, the relative contributions of fibrinogen, platelet count and clot firmness to blood..

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Propofol-supplemented cardioplegia: A multicenter blinded 3-group randomized trial (Propofol for Myocardial Protection Trial 2: ProMPT2)

Abstract Objective Coronary artery bypass grafting using cardiopulmonary bypass and cardioplegic arrest is an effective treatment for coronary artery disease. Research suggests supplementing the cardioplegia solution with propofol may be..

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Benefits of nitric oxide administration during cardiopulmonary bypass on postoperative outcomes in adult patients: a meta-analysis and systematic review

Abstract Background Nitric oxide (NO) is reported to play several protective roles in the inflammatory response and ischemia/reperfusion injury. This study evaluated the effect of nitric oxide (NO) on postoperative..

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Contemporary Clinical Practices in Anticoagulation Management During Cardiopulmonary Bypass: A Europe-Wide Survey

Abstract Objectives Clinical practice in anticoagulation management, particularly in heparin administration, monitoring, reversal and haemostasis, is known to differ significantly. To better characterize this variability, we conducted a Europe-wide survey..

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Contemporary Clinical Practices in Anticoagulation Management During Cardiopulmonary Bypass: A Europe-Wide Survey

Abstract Objectives Clinical practice in anticoagulation management, particularly in heparin administration, monitoring, reversal and haemostasis, is known to differ significantly. To better characterize this variability, we conducted a Europe-wide survey..

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Vasopressor Requirements after Initiation of Venovenous Extracorporeal Membrane Oxygenation in Patients with Severe Respiratory Failure

Abstract Background Patients with severe respiratory failure frequently suffer from concomitant haemodynamic compromise. By correcting respiratory acidosis and permitting reduced mechanical ventilation pressures, venovenous extracorporeal membrane oxygenation (V-V ECMO) may..

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Long-term thrombus-free left atrial appendage occlusion via magnetofluids

Abstract Peri-device leak and device-related thrombus remain key challenges of current left atrial appendage occlusion (LAAO) owing to the incompatibility between the solid occluder and the left atrial appendage (LAA). Here..

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Extracorporeal Carbon Dioxide Removal in Acute Respiratory Distress Syndrome: Physiologic Rationale and Phenotype-Based Perspectives

Abstract Acute respiratory distress syndrome (ARDS) is a major cause of morbidity and mortality despite decades of progress in ventilatory support. Mechanical ventilation, while essential for oxygenation, may exacerbate lung..

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Regional Variation in Congenital Heart Surgery in Brazil: A National Database Analysis

Abstract Introduction: The absence of a congenital heart surgery national registry limits understanding of access, surgical volume, and mortality. This study analyzes the Brazilian administrative data to assess procedural distribution, outcomes,..

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Socioeconomic status and ECMO outcomes in severe ARDS

Abstract Background Socioeconomic inequalities have been associated with adverse outcomes in critically ill COVID-19 patients. Whether these disparities extend to the most severe ARDS patients treated with ECMO, regardless of..

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Obesity Does Not Influence the Outcomes of Minimally Invasive Mitral Valve Repair for Mitral Regurgitation: A Longitudinal Analysis

Abstract Objectives Data on the role of obesity in patients undergoing minimally invasive cardiac surgery are sparse, and the longitudinal observations after minimally invasive mitral valve repair (MI-MVr) in obese..

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Comparison between regional citrate anticoagulation and systemic heparin anticoagulation in patients undergoing continuous renal replacement therapy and venoarterial extracorporeal membrane…

Abstract Introduction Regional citrate anticoagulation (RCA) is the recommended first-line strategy for continuous renal replacement therapy (CRRT) circuits. Acute kidney injury is common in patients undergoing venoarterial extracorporeal membrane oxygenation..

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Association of duration of amino acids infusion and renal protection: a secondary analysis of the PROTECTION trial

Abstract Background Intravenous amino acids (AA) reduce acute kidney injury (AKI) in adult patients undergoing cardiac surgery. Because the optimal duration of AA infusion is unknown, we investigated the effect..

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Prevalence of Musculoskeletal Disorders Among Perfusion Staff in Germany

Abstract Background: Musculoskeletal disorders (MSDs) are highly prevalent among healthcare workers, particularly nurses, with reported prevalence rates ranging from 57% to 93%. Perfusionists are highly specialized healthcare professionals responsible for operating..

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