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The impact of pulsatile vs. non-pulsatile perfusion in patients undergoing cardiopulmonary bypass: A comprehensive systematic review and meta-analysis of 33…

Abstract Background Pulsatile perfusion is a developing technique that attempts to mimic the natural pulsatile flow of blood during cardiopulmonary bypass (CBP). Purpose This systematic review and meta-analysis was conducted..

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Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis

Abstract Background Extracorporeal cardiopulmonary resuscitation (ECPR) may reduce mortality and improve neurological outcomes in patients with cardiac arrest. We updated our existing meta-analysis and trial sequential analysis to further evaluate..

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Does cannulation site affect outcomes of antegrade cerebral perfusion in aortic arch surgery? A meta-analysis of axillary versus innominate access

Abstract Background The optimal arterial cannulation strategy for establishing antegrade cerebral perfusion during aortic arch surgery remains a subject of ongoing debate. Our meta-analysis compares outcomes between axillary artery (AxA)..

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Between Hope and Harm: A Meta-Synthesis of Family Decision-Making Agonies in ECMO Initiation Crossroads

Abstract Background Family members making decisions about ECMO initiation face high-stakes uncertainty, emotional stress and cultural–ethical dilemmas. However, existing research lacks a synthesised understanding of these decision-making experiences across contexts...

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European Resuscitation Council Guidelines 2025 Special Circumstances in Resuscitation

Abstract These European Resuscitation Council (ERC) Guidelines 2025 on Special Circumstances in Resuscitation are based on the 2025 Consensus on Science with Treatment Recommendations (CoSTR) of the International Liaison Committee..

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Evaluation of Knowledge, Attitudes, and Experiences of Perfusionists on the Safety of Cardiopulmonary Perfusion

Abstract Introduction Perfusion accidents still threaten the safety of perfusion during open-heart surgery. To prevent these accidents and increase perfusion safety, it is important to first determine the profile of..

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Shaping the Future of Partial Heart Transplantation: Innovations and Emerging Applications

Abstract Introduction Partial heart transplantation (PHT) represents a novel and adaptable approach to cardiac surgery, allowing for patient-specific and disease-specific interventions while expanding the donor pool and improving organ stewardship...

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Ethical Dilemmas Surrounding ECMO Withdrawal: A Qualitative Empirical Study

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a critical, life-sustaining intervention often described as ‘a bridge to nowhere’ due to its transient nature and the ethical complexities it entails. This..

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Effect of intraoperative cell salvage on postoperative blood transfusion demand outcomes in cesarean section with placenta previa: a retrospective study…

Abstract Background This study aimed to analyze the postoperative blood transfusion demand and safety of intraoperative cell salvage (ICS) without leukocyte depletion filters in cesarean sections complicated by placenta previa...

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Propofol-supplemented cardioplegia: A multicenter blinded 3-group randomized trial (Propofol for Myocardial Protection Trial 2: ProMPT2)

Abstract Objective: Coronary artery bypass grafting using cardiopulmonary bypass and cardioplegic arrest is an effective treatment for coronary artery disease. Research suggests supplementing the cardioplegia solution with propofol may be..

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Does Autologous Platelet-Rich Plasma Improve Blood Conservation and Postoperative Outcomes in Acute Type A Aortic Dissection Surgery? A Systematic Review…

Abstract Objectives To evaluate whether autologous platelet-rich plasma (aPRP) improves blood conservation and postoperative outcomes in emergency surgery for acute type A aortic dissection (ATAAD). Design Systematic review and meta-analysis..

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Prognostic value of venous-to-arterial pCO2 gap during cardiopulmonary bypass for predicting cardiac surgery-associated kidney injury: A bicentric retrospective study

Abstract Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most frequent and severe complications after cardiac surgery. The association between acute kidney injury and the mismatch between..

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Extracorporeal cardiopulmonary resuscitation in trauma patients: An analysis of the ELSO registry

Abstract Background Cardiac arrest in trauma patients can occur from traumatic or non-traumatic aetiologies. Traditionally, trauma has been regarded a contraindication for extracorporeal life support, particularly extracorporeal cardiopulmonary resuscitation (ECPR)...

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Multisite Venovenous Extracorporeal Membrane Oxygenation in Pediatric Patients Under 15 kg: Three-Center, Analysis of Surgical Versus Percutaneous Approach and Thrombosis…

Abstract Objectives:  An increasing number of pediatric centers use the femoral vein in neonates and smaller children to provide venovenous multisite (VVMS) extracorporeal membrane oxygenation (ECMO), but there are no..

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Supplemental Cardioplegia During Heart Transplant Implantation

PRO Cardioplegia, the intentional and temporary arrest of the heart during cardiac surgery, has been a cornerstone of modern heart transplantation, enabling myocardial protection during ischemic periods. Its use dates..

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Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan

Abstract Background Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective..

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Plasma Exchange in the Setting of Immune-Mediated Multiple Organ Failure in the Cardiac ICU During ECMO: A Case Series

Abstract Extracorporeal membrane oxygenation (ECMO) is a last resort treatment for children with cardio-respiratory failure. Some of these patients will develop thrombocytopenia-associated multiple organ failure (TAMOF), which is sometimes managed..

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A randomised pilot study evaluating music therapy and virtual reality mindfulness sessions for reducing anxiety and stress in patients undergoing…

Abstract Cardiac surgery patients may experience stress and anxiety, negatively impacting recovery. Pharmacological treatments are frequently used but may result in side effects. We aimed to assess the effectiveness of..

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The association between intraoperative end-tidal carbon dioxide and prognosis in cardiac surgery patients: a retrospective cohort study

Abstract Background To evaluate the association between intraoperative end-tidal carbon dioxide (ETCO₂) levels and clinical outcomes in patients undergoing cardiac surgery. Methods This retrospective analysis included patients who underwent cardiac..

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The impact of remote ischemic preconditioning on postoperative outcomes in pediatric cardiac surgery: an updated systematic review and meta-analysis

Abstract Remote ischemic preconditioning (RIPreC) has been regarded as a promising strategy to reduce ischemia-reperfusion injury to the heart and other organs caused by cardiopulmonary bypass. While RIPreC has demonstrated..

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Development, Validation, and Testing of a Simple Risk Score System Incorporating Routine Clinical and Laboratory Variables to Predict Moderate-to-Severe Acute…

Abstract Objectives Early prediction is crucial for cardiac surgery-associated acute kidney injury (CSA-AKI). We aimed to develop and validate a simple, clinical- and laboratory-based risk score system for better CSA-AKI..

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Neuromonitoring and neuroprotection during neonatal aortic arch surgery: A United Kingdom and Ireland survey

Abstract Introduction Neonatal aortic arch surgery is associated with neurological morbidity of varying severity which is detected and potentially limited through neuroprotective strategies. We conducted a survey of healthcare professionals..

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Differential Hypoxemia During Veno-Arterial Extracorporeal Organ Support: Its Impact on Mortality and Different Treatment Strategies

Abstract Objectives Extracorporeal Life Support (ECLS) has evolved into an established treatment for severe cardiogenic shock. As most patients have residual antegrade left ventricular output toward the descending aorta that..

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Characteristics Associated with Mortality in 623 Patients Who Received Recombinant Factor VIIa for Bleeding in Cardiac Surgery

Abstract Objectives Activated recombinant factor VII (rFVIIa) has been used to treat cardiac surgical bleeding in an off-label manner. Due to the high risk of mortality with ongoing hemorrhage, assessing..

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Routine administration of enoximone in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass to prevent and treat early low…

Abstract Low cardiac output syndrome (LCOS) is defined by an insufficient cardiac output to meet metabolic demands, leading to tissue hypoperfusion and potential organ dysfunction. Although it affects up to 42%..

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Dose-Dependent Changes in Clot Firmness in Thromboelastometry After Administration of Fibrinogen Concentrate: A Retrospective Observational Study

Abstract Introduction Viscoelastic point-of-care diagnostics are crucial in cardiac surgery. In the FIBTEM assay of rotational thromboelastometry (ROTEM), guidelines suggest target maximum clot firmness values to reduce perioperative bleeding. The..

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Advances and Challenges in Artificial Womb for Respiratory Support in Extremely Low Gestational Age Neonates: A Narrative Review

Abstract Background Respiratory management of extremely low gestational age neonates (ELGANs) is a major challenge in neonatal intensive care, as they face high mortality and morbidity due to complications such..

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Cerebral Hemodynamic Changes and Postoperative Brain Function in Patients Undergoing Cardiac Valve Surgery With Cardiopulmonary Bypass: A Prospective Cohort Study

Abstract Background Cardiopulmonary bypass (CPB) during cardiac surgery disrupts cerebral hemodynamics, potentially leading to postoperative neurological complications such as delirium. Transcranial Doppler (TCD) offers non-invasive monitoring of cerebral blood flow..

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Thrombus formation in neonates and early infants undergoing congenital heart surgery

Abstract Objective This study evaluated thrombus formation and its impact on outcomes in neonates and early infants undergoing congenital heart surgery. Methods Neonates and early infants (≤90 days) undergoing congenital..

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Comparison of post-operative inflammatory biomarkers between minimal invasive extracorporeal circulation and conventional extracorporeal circulation in cardiac surgery. A meta-analysis of…

Abstract Background/Aim Recent literature suggested that the use of Minimal Invasive Extracorporeal Circulation (MIECC) may mitigate the inflammatory response in patients undergoing cardiac surgery. We aimed to perform a meta-analysis..

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