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Acute Kidney Injury and Extracorporeal Membrane Oxygenation: Review on Multiple Organ Support Options

Abstract Extracorporeal membrane oxygenation (ECMO) is a temporary life support system used to assist patients with life-threatening severe cardiac and/or respiratory insufficiency. Patients requiring ECMO can be considered the sickest..

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Elimination of CO2 insufflation-induced hypercapnia in open heart surgery using an additional venous reservoir

Abstract     OBJECTIVES Carbon dioxide (CO2) gas insufflation is used for continuous de-airing during open heart surgery. The aim was to evaluate if an additional separate venous reservoir eliminates..

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Cerebral microemboli during extracorporeal life support: a single-centre cohort study

Abstract   OBJECTIVES The aim of this study was to investigate the load and composition of cerebral microemboli in adult patients undergoing venoarterial extracorporeal life support (ECLS). METHODS Adult ECLS..

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Early Neurological Pupil Index Assessment to Predict Outcome in Cardiac Arrest Patients Undergoing Extracorporeal Membrane Oxygenation

Hypoxic-ischemic brain injury is the main cause of death or disability in patients resuscitated from cardiac arrest (CA). Veno-arterial extracorporeal membrane oxygenation (VA ECMO) may be used as a mechanical support for..

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High Socioeconomic Deprivation and Coronary Artery Bypass Grafting Outcomes: Insights from Michigan

Abstract Background Cardiovascular outcomes are worse among individuals from areas with limited socioeconomic resources. This study evaluated the relationship between high socioeconomic deprivation and isolated coronary artery bypass grafting (CABG)..

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Dextran-based priming solution during cardiopulmonary bypass attenuates renal tubular injury—A secondary analysis of randomized controlled trial in adult cardiac surgery…

Abstract Background Acute kidney injury (AKI) is a well-known complication after cardiac surgery and cardiopulmonary bypass (CPB). In the present secondary analysis of a blinded randomized controlled trial, we evaluated..

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Non-Governmental Organizations Delivering Global Cardiac Surgical Care: A Quantitative Impact Assessment

Abstract In low- and middle-income countries (LMICs), 93% of the population lacks safe, timely, and affordable access to cardiac surgical care when needed. As countries slowly build or expand local,..

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Comparison of the Effects of Ringer’s Lactate and 6% Hydroxyethyl Starch 130/0.4 on Blood Loss and Need for Blood Transfusion…

Abstract Background Infusion of crystalloids fluid replacement therapy tends to cause a greater expansion of intravascular volume. However, colloids can affect blood coagulation leading to greater blood loss and transfusion requirements. This..

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Which factors have a great impact on coagulopathy and hemostatic impairment after cardiopulmonary bypass in cardiovascular surgery? An analysis based…

Abstract Objectives This study aimed to investigate which factors have a great impact on coagulopathy after cardiopulmonary bypass (CPB) using rotational thromboelastometry (ROTEM). Methods Ninety-eight patients undergoing cardiovascular surgery using..

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Postoperative Nadir Hemoglobin and Adverse Outcomes in Patients Undergoing On-Pump Cardiac Operation

Abstract Background Patients undergoing cardiac operation are susceptible to anemia. Low hemoglobin concentration is a risk factor for composite adverse events and death after cardiac operation. Here we investigated the association of..

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Patient blood management and blood conservation – Complimentary concepts and solutions for blood establishments and clinical services in South Africa…

Abstract  come with risks and high costs, and should be utilized only when clinically indicated. Decisions to transfuse are however not always well informed, and lack of clinician knowledge and..

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‘He’s done so well’: Recipient of first new generation heart transplant is recovering as expected

A Duke medical team successfully performed the first new generation artificial heart transplant in history in July. Over a month later, recipient Matthew Moore is recovering as expected.   The recipient’s wife..

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Clinician Ethical Perspectives on Extracorporeal Membrane Oxygenation in Practice

Abstract Purpose: Extracorporeal membrane oxygenation (ECMO) is an expensive and scarce life sustaining treatment provided to certain critically ill patients. Little is known about the informed consent process for ECMO..

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The Albumin-to-Fibrinogen Ratio Independently Predicts Acute Kidney Injury in Infants With Ventricular Septal Defect Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Abstract Background: Acute kidney injury (AKI) is a common and serious complication faced by children following ventricular septal defect (VSD) surgery with cardiopulmonary bypass (CPB). The objective of this study was..

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The Association of Matrix Metalloproteinases With Acute Kidney Injury Following CPB-Supported Cardiac Surgery

Abstract Background: Cardiac surgery–associated acute kidney injury (AKI) is an adverse outcome that increases morbidity and mortality in patients undergoing cardiac surgical procedures. To date, the use of serum creatinine..

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Severe thrombocytopenia in adults undergoing extracorporeal membrane oxygenation is predictive of thrombosis

Abstract Extracorporeal membrane oxygenation (ECMO) provides lifesaving circulatory support and gas exchange, although hematologic complications are frequent. The relationship between ECMO and severe thrombocytopenia (platelet count <50 × 109/L) remains ill-defined. We performed..

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Cross-Circulation for Extracorporeal Liver Support in a Swine Model

Abstract Although machine perfusion has gained momentum as an organ preservation technique in liver transplantation, persistent organ shortages and high waitlist mortality highlight unmet needs for improved organ salvage strategies...

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Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic

Abstract Dear Editor, In the earliest phases of the pandemic, the use of extracorporeal life support in patients with severe coronavirus disease 2019 (COVID-19) was associated with disastrous outcomes. However,..

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Dynamic and Hybrid Configurations for Extracorporeal Membrane Oxygenation

Abstract Dynamic or hybrid configurations for extracorporeal membrane oxygenation (ECMO) are needed when patient physiology or clinical conditions change. Dynamic configurations included configurations converting from veno-arterial (V-A) ECMO or veno-venous..

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Centrifugal and Roller Pumps in Neonatal and Pediatric Extracorporeal Membrane Oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) is an invaluable means of supporting critically ill children with refractory respiratory or cardiac failure. Controversy remains; however, whether roller or centrifugal pumps are superior,..

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The Potential Role of Extracorporeal Cytokine Removal in Hemodynamic Stabilization in Hyperinflammatory Shock

Abstract Hemodynamic instability due to dysregulated host response is a life-threatening condition requiring vasopressors and vital organ support. Hemoadsorption with Cytosorb has proven to be effective in reducing cytokines and..

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Factor XI Inhibition to Uncouple Thrombosis From Hemostasis: JACC Review Topic of the Week

Abstract Hemostasis and thrombosis are believed to be so intricately linked that any strategies that reduce thrombosis will have an inevitable impact on hemostasis. Consequently, bleeding is viewed as an unavoidable..

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Costs and consequences of acute kidney injury after cardiac surgery: A cohort study

Abstract Objectives  (AKI) is common after cardiac surgery. We quantified the mortality and costs of varying degrees of AKI using a population-based cohort in Alberta, Canada. Methods A cohort of..

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Anatomy of Mitral Valve Complex as Revealed by Non-Invasive Imaging: Pathological, Surgical and Interventional Implications

Abstract Knowledge of mitral valve (MV) anatomy has been accrued from anatomic specimens derived by cadavers, or from direct inspection during open heart surgery. However, today two-dimensional and three-dimensional transthoracic..

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Comparison of stored red blood cell washing techniques for priming extracorporeal circuits

Abstract Background: The aim of this study was to compare three different blood washing techniques and describe the differences for the composition of the washed red blood cells (RBC). Methods:..

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How to Turn It Down: The Evidence and Opinions Behind Adult Venoarterial Extracorporeal Membrane Oxygenation Weaning

Abstract Adequate and durable recovery in patients supported with venoarterial (VA) extracorporeal membrane oxygenation (ECMO) can be challenging to predict. Extracorporeal membrane oxygenation weaning is the process by which the..

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Virtual reality device training for extracorporeal membrane oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) is a last resort therapy for patients with terminal respiratory failure. In the current worldwide surge of critically ill patients with novel coronavirus disease (COVID-19),..

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ECMO During a Pandemic: A COVID-19 Quality Improvement Process

Abstract Extracorporeal membrane oxygenation is a modified form of cardiopulmonary bypass and a complex adult critical care therapy. No evidence appears to exist on sustaining relevant quality nursing standards during..

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Priming solution for neonatal and pediatric cardiopulmonary bypass

Abstract The Priming volume of the oxygenators has been reduced by 75% during the last two decades and it is now possible to go safely on bypass with a priming..

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Why is saline so acidic (and does it really matter?)

Abstract Commercial 0.9% saline solution for infusion has a pH around 5.5. There are many reasons for this acidity, some of them still obscure. It is also true that infusion..

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