Abstract Malignant hyperthermia (MH) is a rare but potentially fatal disorder characterized by a hypermetabolic state produced by exposure to triggering agents such as volatile anesthetics and succinylcholine., MH crises have..
Read MoreAbstract Background Cardiac surgery with cardiopulmonary bypass (CPB) is associated with microcirculatory changes. Little is known about the effect of CPB on the structural and vascular parameters of the retina...
Read MoreAbstract INTRODUCTION Unfractionated heparin (UFH) is the most commonly used anticoagulant during extracorporeal membrane oxygenation (ECMO) (1). However, UFH also has several limitations: (i) it requires individualized dosing and close..
Read MoreAbstract Introduction Veno-venous extracorporeal membrane oxygenation (VV ECMO) is a life-sustaining technology that supports patients with severe acute respiratory failure. Indications and contraindications to VV ECMO are evolving and professional..
Read MoreAbstract Background Patients undergoing cardiac surgery frequently suffer impaired myocardial redox protection during cardiopulmonary bypass (CPB), with elderly patients facing higher complication risks. We investigated the redox-protective effects of blood..
Read MoreAbstract Background: Intraoperative iatrogenic aortic dissection (IAD) is an uncommon but serious complication of cardiac surgery, and available evidence remains limited, with most reports based on small series. This study..
Read MoreAbstract Background Acute kidney injury (AKI) is a common complication after pediatric cardiac surgery using cardiopulmonary bypass (CPB). This study evaluated renal regional oxygen saturation (R-rSO₂), measured via near-infrared spectroscopy..
Read MoreAbstract More than 1 million patients worldwide undergo cardiac surgery each year, amounting to approximately 123 per 100,000 population. Cardiopulmonary bypass has been central to this success, facilitating the possibility of..
Read MoreAbstract BACKGROUND: Haptoglobin may reduce hemolysis-induced kidney injury in patients undergoing cardiovascular surgery with cardiopulmonary bypass (CPB). Haptoglobin may be given empirically when hemolytic urine is observed, or pre-emptively when..
Read MoreAbstract Objectives Del Nido cardioplegia has gained increasing popularity, evolving from its original use in paediatric and congenital heart surgery to widespread adoption in adult cardiac procedures. This review aims..
Read MoreAbstract The aim of this study is to investigate the mechanical influence on the aortic tissue when exposed to the liquid jet blasting effect produced by the aortic cannula during..
Read MoreAbstract Background Advances in medicine lead to an increase in the number of patients with concurrent heart disease and cancer. We investigated the effect of cardiac surgery under cardiopulmonary bypass..
Read MoreAbstract Introduction Continuous retrograde cardioplegia worsens surgeon’s vision while performing distal anastomosis in coronary artery bypass grafting operations. We investigated whether intermittent retrograde cardioplegia, which provides a bloodless surgical field..
Read MoreAbstract Objectives This quality improvement project aimed to enhance operating room efficiency in a newly established paediatric cardiac operating room by focusing on key performance indicators (KPI), including (1) first..
Read MoreAbstract Design Apixaban is a direct oral anticoagulant that inhibits factor Xa. Our objective was to examine the effect of apixaban on perioperative transfusion requirements in pediatric patients undergoing cardiac..
Read MoreAbstract Hemodynamic monitoring is a cornerstone of perioperative care in cardiac surgery, where patients are at high risk of cardiovascular instability and organ hypoperfusion. In recent years, goal-directed therapy (GDT)..
Read MoreAbstract Objectives This study hypothesizes that induced hypothermia (IH) can safely extend aortic cross-clamp (ACC) time, significantly reducing metabolic burden and end-organ injury, thereby enabling more comprehensive aortic arch reconstructions..
Read MoreAbstract Objective Heparin-induced thrombocytopenia (HIT) is a serious concern in cardiac surgery, as heparin use in the at-risk patient can lead to devastating thrombosis. Management strategies for patients with confirmed..
Read MoreAbstract Extracorporeal membrane oxygenation (ECMO) may be a life-saving intervention for patients with respiratory or cardiac failure or cardiac arrest. Storing wet-preprimed ECMO circuits can reduce the time to initiate..
Read MoreAbstract Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs...
Read MoreAbstract Objectives Cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) or life support (ECLS) circuits are built from polymers and might release polymeric micro- and nanoparticles (MNP) into the circulation...
Read MoreAbstract Background Optimal hemodynamic targets for preventing acute kidney injury (AKI) have remained elusive. We hypothesized that lower tissue perfusion pressure (TPP), a novel perfusion index representing the difference between..
Read MoreAbstract Extracorporeal membrane oxygenation (ECMO) provides temporary support for patients with severe acute cardiac or respiratory failure. Although thrombotic complications are common during ECMO, the real-time detection and management of..
Read MoreAbstract The transfusion of ABO compatible but not ABO identical red blood cells and plasma and the transfusion of platelets and cryoprecipitate without concern for ABO in any manner, are..
Read MoreAbstract Background Effective communication is critical for patient safety and surgical outcomes inside the operating room (OR). Labeled surgical caps have been proposed as a strategy to improve intraoperative communication..
Read MoreAbstract Introduction Extracorporeal membrane oxygenation (ECMO) is a high-risk, low-frequency intervention requiring specialized training and effective teamwork, for which simulation-based training is a valuable tool. Across medical disciplines escape room-style..
Read MoreAbstract Background Protamine has a more difficult side-effect profile. Circulatory collapse has been reported as a result of acute pulmonary artery spasm caused by complement cascade activation by large heparin–protamine..
Read MoreAbstract Background During cardiac surgery the use of a minimal extracorporeal circulation (MiECC) system may reduce the adverse effects for the patient. This is probably caused by reduced inflammation and..
Read MoreAbstract Background/Objectives: In the present study, we hypothesized that cardiac surgery in pediatric patients with congenital heart disease (CHD) leads to profound endothelial glycocalyx degradation, measured as the increase in..
Read MoreAbstract Background Lung transplantation represents the most definitive treatment option for patients with advanced-stage lung diseases. In recent years, improvements in anesthetic techniques, medical technologies, and coordinated perioperative care have..
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