Abstract BACKGROUND: Prior studies identified thresholds for mean arterial pressure (MAP <65 mm Hg) and central venous pressure (CVP >12 mm Hg) beyond which risk for cardiac surgery-associated acute kidney..
Read MoreAbstract Background Current indicators for monitoring intraoperative organ function remain predominantly indirect, delayed and non-specific, particularly in paediatric populations undergoing congenital heart surgery, where multifactorial influences further complicate functional assessments. Emerging..
Read MoreAbstract Objective Acute kidney injury (AKI) affects approximately 30% of patients undergoing cardiac surgery with conventional non-pulsatile cardiopulmonary bypass (CPB). Pulsatile flow has long been proposed for mitigating this complication...
Read MoreAbstract OBJECTIVES Acute kidney injury (AKI) is a common consequence of surgical repair of the thoraco-abdominal aorta (TAA). Perfusion techniques aim to facilitate renal protection through oxygenation or hypothermia. This..
Read MoreAbstract Purpose Cardiac surgery associated acute kidney injury (CSA-AKI) is a frequent and severe complication. Goal Directed Perfusion (GDP) during cardiopulmonary bypass (CPB) has been developed to reduce post-operative complications,..
Read MoreAbstract Acute Kidney Injury (AKI) is a common complication after cardiac surgery affecting up to 40% leading to increased morbidity and mortality. To date, there is no specific treatment for..
Read MoreAbstract Heart failure remains a leading cause of morbidity and mortality globally, particularly among individuals with advanced forms of the disease. This study introduces a groundbreaking hydromagnetic artificial heart..
Read MoreAbstract The use of extracorporeal membrane oxygenation has been increasing over time, in part due to the COVID-19 pandemic. Whilst lifesaving, complications that must be managed are also associated with..
Read MoreAbstract Objective Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used to rescue patients in cardiac arrest. However, minimal data guide candidacy decisions, and centers must develop their own initiation criteria, raising..
Read MoreAbstract Background: Postoperative Acute kidney injury (AKI) is a significant concern for cardiac surgery patients with chronic kidney disease (CKD). Effective pharmacological interventions to mitigate these risks are urgently needed...
Read MoreAbstract In recent decades, multiple efforts have been made to reduce population exposure to cigarettes, given that smoking is responsible for thousands of deaths annually. These actions have been effective,..
Read MoreAbstract Perioperative pulmonary arterial hypertension (PAH) is a common complication of chest surgery with cardiopulmonary bypass (CPB) and its etiology is multifactorial. Patients undergoing this surgery often have underlying conditions,..
Read MoreAbstract Objectives To study the association between bleeding and acute kidney injury (AKI). Design Post-hoc study of a randomized trial of 4% albumin versus Ringer's acetate for cardiopulmonary bypass priming..
Read MoreAbstract Acute kidney injury (AKI) is a complex clinical syndrome with a spectrum of clinical manifestations and outcomes (1); characterized by the deterioration of renal function over a period of..
Read MoreAbstract Background Although goal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) has been discussed extensively in adult studies, no pediatric indexed oxygen delivery (Do2i) thresholds are universally accepted, and no pediatric..
Read MoreAbstract Predictive scoring systems for adult patients receiving extracorporeal membrane oxygenation (ECMO) support for sepsis have not been yet reported. Based on the Chinese Society of ExtraCorporeal Life Support (CSECLS)..
Read MoreAbstract Objectives: Previous studies have demonstrated an association between transfusion and increased organ dysfunction. We sought to determine the association between transfusion of blood components (red blood cell [RBC], plasma, platelet,..
Read MoreAbstract The study Women in cardiac surgery: A global workforce analysis by Izumi et al. [1] provides important insights into women’s representation in the field of cardiac surgery worldwide and offers a useful benchmark..
Read MoreAbstract Background Coronary artery bypass grafting (CABG) is one of the most effective treatments for improving the quality of life in patients with severe coronary artery disease. However, these patients..
Read MoreAbstract Background The optimal fluid management strategy for patients undergoing on-pump cardiac surgery was controversial regarding the fluid types. This study aimed to compare the impact of hydroxyethyl starch (HES)..
Read MoreAbstract Importance Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an..
Read MoreAbstract Background Acute kidney injury (AKI) is a common and serious complication after coronary artery bypass grafting (CABG), significantly affecting patient outcomes. The triglyceride-glucose (TyG) index, a marker of insulin..
Read MoreAbstract Extracorporeal carbon dioxide removal (ECCO2R) is an emerging technique designed to reduce carbon dioxide (CO2) levels in venous blood while enabling lung-protective ventilation or alleviating the work of breathing...
Read MoreAbstract “Mechanotransduction” is a term I would use to describe my research topic, and it works perfectly well, as long as the goal is to earn confused looks and immediately..
Read MoreAbstract Critically ill patients that require kidney replacement therapy (KRT) are among the most ill and complex patients routinely encountered in the intensive care unit (ICU). Continuous KRT (CKRT) is..
Read MoreAbstract Human serum albumin (HSA) is a non-glycosylated, negatively charged, single-chain polypeptide composed of 585 amino acid residues with a relative molecular mass of 66.438 kD. It is synthesized by..
Read MoreAbstract Chronic kidney disease (CKD) affects 50% of patients with heart failure. The pathophysiology of CKD in heart failure is proposed to be driven by macrocirculatory hemodynamic changes, including reduced..
Read MoreAbstract Background:Cardiac surgery-associated acute kidney injury (CS-AKI) and fluid overload (FO) are common among neonates who undergo cardiopulmonary bypass, and increase mortality risk. Current diagnostic criteria may delay diagnosis. Thus,..
Read MoreAbstract Background Extracorporeal membrane oxygenation (ECMO) stands as a pivotal intervention for patients grappling with cardiopulmonary insufficiency. However, alongside its therapeutic benefits, ECMO carries the risk of complications, with acute..
Read MoreAbstract Cardiogenic shock (CS) is a critical condition with high mortality, characterized by reduced cardiac output (CO) and tissue hypoperfusion, despite advancements in treatment. Traditional hemodynamic markers like CO measurements,..
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