Extracorporeal membrane oxygenation (ECMO) is a treatment that provides hemodynamic or respiratory support to severely critically ill patients. However, ECMO introduces many variables that must be considered for antibiotic pharmacodynamics and pharmacokinetics to minimize risks and maximize the therapeutic benefit. Since ECMO use in those with systemic infection is increasing, it is crucial to understand the interactions between ECMO, its derived techniques, and antibiotics in order to ensure successful patient care.