Acute kidney injury (AKI) is a frequent and severe problem following heart surgery, particularly in procedures involving cardiopulmonary bypass (CPB). This research investigates the Randomized Controlled Trial (RCT) on the impact of agents of anesthetic on renal function in patients receiving elective cardiac surgery and CPB, comparing propofol-based and volatile anesthetic-based regimens. A sum of 61 patients was randomly assigned into two regions: one receiving a propofol-based regimen and the other, a volatile anesthetic regimen, both combined with opioid analgesia. Renal function was assessed preoperatively and postoperatively at 24 and 48 h using serum creatinine and cystatin C levels. Perioperative inflammatory markers were deliberate to evaluate inflammation-mediated renal impairment multivariate logistic regression identified risk factors for AKI, and independent t-tests compared renal function parameters between regimens. Patients receiving propofol exhibited significantly lower rates of AKI (Read the full text