Perfusfind S.L.
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Advancing Cardiac Critical Care: A Call for Training, Collaboration, and Family Engagement

Abstract The evolution and development of pediatric cardiac critical care as a distinct subspecialty have occurred rapidly over the past 20 years. As the field has grown, models for education,..

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Long-Term Outcome of Patients With Chronic Thromboembolic Pulmonary Hypertension: Results From an International Prospective Registry

Abstract Background: Chronic thromboembolic pulmonary hypertension, a rare complication of acute pulmonary embolism, is characterized by fibrothrombotic obstructions of large pulmonary arteries combined with small-vessel arteriopathy. It can be cured by..

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Early versus late surgical intervention or medical management for infective endocarditis: a systematic review and meta-analysis

Abstract Objective Infective endocarditis is associated with high morbidity and mortality and optimal timing for surgical intervention is unclear. We performed a systematic review and meta-analysis to compare early surgical intervention..

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Poly-2-methoxyethylacrylate-coated cardiopulmonary bypass circuit can reduce transfusion of platelet products compared to heparin-coated circuit during aortic arch surgery

Abstract Several coating techniques for extracorporeal circulation have been developed to reduce the systemic inflammatory response during cardiopulmonary bypass (CPB). We compared the clinical effectiveness and biocompatibility of poly-2-methoxyethylacrylate (PMEA)-..

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Blood Transfusion and 30-Day Mortality in Patients With Coronary Artery Disease and Anemia Following Noncardiac Surgery

Abstract Importance  Although liberal blood transfusion thresholds have not been beneficial following noncardiac surgery, it is unclear whether higher thresholds are appropriate for patients who develop postoperative myocardial infarction (MI). Objective  To..

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Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

Abstract Importance  Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported variation in epidemiology challenge the validity of this definition.Objective  To develop..

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Applying a low-flow CO2 removal device in severe acute hypercapnic respiratory failure

Abstract A novel and portable extracorporeal CO2-removal device was evaluated to provide additional gas transfer, auxiliary to standard therapy in severe acute hypercapnic respiratory failure. A dual-lumen catheter was inserted..

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Cerebral Autoregulation Monitoring with Ultrasound-Tagged Near-Infrared Spectroscopy in Cardiac Surgery Patients

Abstract BACKGROUND:  Individualizing mean arterial blood pressure (MAP) based on cerebral blood flow (CBF) autoregulation monitoring during cardiopulmonary bypass (CPB) holds promise as a strategy to optimize organ perfusion. The..

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Propofol cardioprotection for on-pump aortocoronary bypass surgery in patients with type 2 diabetes mellitus (PRO-TECT II): a phase 2 randomized-controlled…

Abstract Purpose The efficacy of myocardial conditioning strategies is compromised in patients with advanced age, diabetes, or low ejection fraction. We conducted a single-centre parallel-arm blinded randomized-controlled trial to determine..

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Survival and quality of life after extracorporeal life support for refractory cardiac arrest: A case series

Abstract Objectives  life support (ECLS) is an emerging option to treat selected patients with cardiac arrest refractory to cardiopulmonary resuscitation (CPR). Our primary objective was to determine the mortality at..

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Clinical evaluation of a novel technology for non‐invasive and continuous measurement of plasma haemoglobin concentration

Abstract We undertook the first clinical evaluation of a novel, non‐invasive device for the continuous measurement of plasma haemoglobin concentration in 25 patients undergoing elective cardiac surgery. At four pre‐determined..

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Prediction of the impact of venoarterial extracorporeal membrane oxygenation on hemodynamics

Abstract Although venoarterial extracorporeal membrane oxygenation (ECMO) was developed to rescue patients with cardiogenic shock, the impact of ECMO on hemodynamics is often unpredictable and can lead to hemodynamic collapse...

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Development of a valve type semi-closed extracorporeal circulation system

Abstract In Japan, perfusionists who work on other clinical tasks are involved in cardiopulmonary bypass. Moreover, the number of cases they can perform is limited. In view of this situation,..

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Equivalent outcomes after coronary artery bypass graft surgery performed by consultant versus trainee surgeons: A systematic review and meta-analysis

Abstract Objective In recent years, concerns have been raised about the learning opportunities available to cardiac surgical trainees. This meta-analysis was conducted to assess the impact of trainee operator status..

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Frequency and outcomes of severe hyperlactatemia after elective cardiac surgery

Abstract Background  is relatively common in the cardiac surgical patient and is usually considered a marker of illness severity. The frequency and impact of severe hyperlactatemia after elective cardiac surgery..

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The effect of hydroxyethyl starch 6% 130/0.4 compared with gelatin on microvascular reactivity

Abstract We compared the effects on microvascular reactivity of hydroxyethylstarch (Volulyte®) and gelatin (Geloplasma®) during acute haemodilution. The hypothesis was that Volulyte would provide better microvascular reactivity than Geloplasma. Forty..

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Long‐Term Post‐CABG Survival: Performance of Clinical Risk Models Versus Actuarial Predictions

Abstract Background/aim Clinical risk models are commonly used to predict short‐term coronary artery bypass grafting (CABG) mortality but are less commonly used to predict long‐term mortality. The added value of..

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Effects of remote ischemic preconditioning in high-risk patients undergoing cardiac surgery (Remote IMPACT): a randomized controlled trial

Abstract Background:  Remote ischemic preconditioning is a simple therapy that may reduce cardiac and kidney injury. We undertook a randomized controlled trial to evaluate the effect of this therapy on..

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Preoperative Ticagrelor administration leads to a higher risk of bleeding during and after coronary bypass surgery in a case-matched analysis

Abstract OBJECTIVES To evaluate the effect of Ticagrelor on intra- and postoperative bleeding complications in patients undergoing coronary bypass surgery. METHODS For this study, patients who underwent on-pump or off-pump..

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Assessment of perioperative mortality risk in patients with infective endocarditis undergoing cardiac surgery: performance of the EuroSCORE I and II…

Abstract OBJECTIVES The European System for Cardiac Operative Risk Evaluation (EuroSCORE) has been established as a tool for assisting decision-making in surgical patients and as a benchmark for quality assessment...

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Splanchnic circulation

Abstract The splanchnic circulation is a complex system. A number of important functions depend on its normal operation, including digestion and absorption within the gut, maintenance of the mucosal barrier,..

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Antithrombin III for critically ill patients

Abstract Background Critical illness is associated with uncontrolled inflammation and vascular damage which can result in multiple organ failure and death. Antithrombin III (AT III) is an anticoagulant with anti‐inflammatory..

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Comparison of Microcirculatory Perfusion in Obese and Non-Obese Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Abstract Obesity is a frequent comorbidity among patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Cardiac surgery with CPB impairs microcirculatory perfusion, which is associated with multiple organ failure. As..

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Intraoperative collection of autologous platelet-rich plasma from the cardiopulmonary bypass circuit upon initiation of extracorporeal circulation

Abstract Objectives The aim of this study is to evaluate the possibility of the autologous platelet-rich plasma (PRP) collection from the cardiopulmonary bypass (CPB) circuit and to evaluate its effect..

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Antibodies against heparin-protamine complexes: Effect and clinical relevance

Abstract The study by Grieshaber and colleagues, “Platelet-activating protamine-heparin-antibodies lead to higher protamine demand in patients undergoing cardiac surgery,” in this issue of the Journal, is a prospective study that joins other..

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Six-Month Survival After Extracorporeal Membrane Oxygenation for Severe COVID-19

Abstract Objectives The authors evaluated the outcome of adult patients with coronavirus disease 2019 (COVID-19)–related acute respiratory distress syndrome (ARDS) requiring the use of extracorporeal membrane oxygenation (ECMO). Design Multicenter..

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Extracorporeal circulation during on‐pump cardiac surgery: an evaluation of the Energy Equivalent Pressure (EEP) index based on waveforms decomposition in…

Abstract The use of pulsatile perfusion (PP) instead of Non‐Pulsatile Perfusion (NP) during cardiopulmonary bypass (CPB) continues to be a source of debate. The disagreements among the conclusions of the..

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Analytical evaluation of the epoc® point-of-care blood analysis system in cardiopulmonary bypass patients

Abstract Objectives The aim of this study was to evaluate the analytical performance of the new epoc® point-of-care blood analysis system in  patients. Design and methods The precision study was conducted..

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Immune and inflammatory role of hydroxyethyl starch 130/0.4 and fluid gelatin in patients undergoing coronary surgery

Abstract Objectives Compare the effects on inflammatory (TNF-α, IL-6, IL-8 and IL-10) and immunologic (CD3+, CD4+, CD8+, CD11b+, CD16+/56+ T cells and total lymphocyte concentration) variables of hydroxyethyl starch 130/0.4, 4%..

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Hydroxyethyl starch solution for extracorporeal tissue perfusion

Abstract In the field of free flap transfer in reconstructive surgery, the trans- or replanted tissue always undergoes cell damage during ischemia to a more or less strong extent. In..

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