Perfusfind S.L.
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Predicting acute kidney injury after CABG: Identification of modifiable intraoperative risk factors

Abstract Aim Acute kidney injury (AKI) is a major complication of coronary artery bypass grafting (CABG). Existing predictive models show limited accuracy and rarely include modifiable intraoperative risk factors. Therefore,..

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Estimated End-Tidal Sevoflurane Concentration to Maintain Optimal Anesthetic Depth During Cardiopulmonary Bypass: A Meta-Analysis

Abstract Background/Objectives: Volatile anesthetic dosing during cardiopulmonary bypass (CPB) is poorly standardized. We estimated the end-tidal sevoflurane (ETsevo) concentration required to maintain adequate anesthesia during CPB and investigated the effects..

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Impact of concomitant intra-aortic balloon pump support on outcomes in patients with acute myocardial infarction-related cardiogenic shock undergoing percutaneous coronary…

Abstract Background Acute myocardial infarction-related cardiogenic shock (AMI-CS) remains associated with extremely high mortality in patients with acute myocardial infarction despite timely revascularization and advances in mechanical circulatory support (MCS)...

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Enhancing early detection of acute brain injury using heart rate variability in patients on venoarterial extracorporeal membrane oxygenation

Abstract Introduction Early detection of acute brain injury (ABI) in patients on venoarterial extracorporeal membrane oxygenation (VA ECMO) is challenging. We aimed to investigate if heart rate variability (HRV) in..

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Prognostic Value of Red Blood Cell Distribution Width in Predicting Acute Kidney Injury After Cardiac Surgery: A Retrospective Cohort Study

Abstract Background/Objectives: Acute kidney injury (AKI) remains a significant complication following cardiac surgery, associated with increased morbidity and mortality. The early detection of AKI is limited by the cost, availability,..

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Improving bleeding and thrombosis in patients with extracorporeal life support: could hematology help?

Abstract Despite the advances in technology, new patient populations, new medications, and multiple monitoring algorithms for anticoagulation, bleeding, and thrombosis complications remain high among those receiving extracorporeal life support (ECLS)..

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Monitoring Hemostatic Function During Extracorporeal Membrane Oxygenation with Point-of-Care Viscoelastic Assays: A Narrative Review

Abstract Extracorporeal membrane oxygenation (ECMO) has increasingly been used in patients with refractory severe cardiorespiratory failure in recent years. The use of ECMO necessitates anticoagulation as blood passes through an..

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Comparison of Cadaveric Warming Rates in Accidental Hypothermia Between Continuous and Dwell Thoracic Lavage

Abstract Background Accidental hypothermia is the unintentional decrease in core body temperature below 35°C due to environmental exposure. Severe hypothermia, defined as a core body temperature less than 28°C, can..

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Percutaneous Versus Surgical Cannulation for Veno-Arterial Extracorporeal Life Support: A Systematic Review and Meta-Analysis

Abstract Background and Aims Extracorporeal life support (ECLS) is a critical intervention in the management of severe cardiac and respiratory failure. Among the commonly used cannulation techniques, percutaneous cannulation (PC)..

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Extracorporeal life support in adult critically ill patients: mechanisms of benefit in respiratory and cardiac failure

Abstract Extracorporeal life support provides temporary cardiorespiratory support for patients with severe, potentially reversible cardiac and/or respiratory failure refractory to conventional measures. Its application has broadened across a wide spectrum..

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Pediatric Extracorporeal Cardiopulmonary Resuscitation (ECPR): Understanding Variations in Systems and Clinical Practice

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) for pediatric cardiac arrest relies on enhanced resources and time-critical decision-making. We aimed to evaluate variations in systems and clinical practice among extracorporeal membrane oxygenation..

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Quality management of comprehensive blood conservation strategies during cardiopulmonary bypass in pediatric cardiac surgery

Abstract Background Pediatric cardiac surgery with cardiopulmonary bypass (CPB) carries substantial transfusion requirements, exposing patients to increased risks of complications during hospital stay. This study evaluates the clinical impact of..

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oXiris in severe cardiogenic shock with endotoxemia: interpreting the negative findings of the CLEAN-ECMO trial

Abstract The recent article by Ko et al., entitled “The effects of extracorporeal blood purification (oXiris®) in patients with cardiogenic shock who require VA-ECMO (CLEAN ECMO): a prospective, open-label, randomized..

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Association Between Targeted Temperature Management and New-Onset Brain Disability in in-Hospital Cardiac Arrest Survivors: A Nationwide Cohort Study

Abstract Objectives Targeted temperature management (TTM) is the standard of care for comatose cardiac arrest survivors. However, evidence regarding its long-term neurological impact specifically on in-hospital cardiac arrest (IHCA) survivors..

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Excessive Anesthetic Depth Is Associated With Increased Rate of Postoperative Delirium After Cardiac Surgery: A Retrospective Analysis of Processed Electroencephalography

Abstract Objectives To evaluate whether prolonged exposure below a Patient State Index (PSI) threshold of 25—considered indicative of excessive anesthesia depth via processed electroencephalography—is associated with postoperative delirium (POD) in..

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Neighborhood Opportunity and Long-Term Outcomes Following Pediatric Extracorporeal Membrane Oxygenation

Abstract Objective To evaluate whether neighborhood-level opportunity, measured by the Child Opportunity Index (COI), is associated with short- and long-term outcomes following pediatric extracorporeal membrane oxygenation (ECMO). Design Retrospective observational..

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The roles and responsibilities of an advanced practice nursing team for coordinating extracorporeal life support in intensive care: A qualitative…

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) is a type of mechanical circulatory support that is increasingly utilised for severe cardiorespiratory failure in the intensive care unit (ICU) setting. ECMO is..

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Perioperative blood loss in cardiac surgery: Validation of machine learning-derived clusters

Abstract Background There is no universally accepted definition of perioperative blood loss in cardiac surgery. Existing methods are based on chest tube output and are not normalised for patient weight...

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Use of extracorporeal membrane oxygenation with a cardiotomy reservoir for patient blood management in thoracoabdominal open surgery: A single centre…

Abstract Open thoracoabdominal aortic aneurysm repair (TAAAR) is associated with mortality rates of between 8% and 25%. One of the characteristics of TAAAR is massive bleeding that requires multiple units..

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Minimal intraoperative anticoagulation strategy for lung transplantation with preoperative heparin-induced thrombocytopenia

Abstract Heparin-induced thrombocytopenia (HIT) in patients on mechanical circulatory support (MCS) prior to lung transplantation poses a unique challenge of balancing thrombotic versus hemorrhagic complications. An alternative method of anticoagulation..

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Artificial Intelligence in Perioperative Cardiothoracic and Vascular Practice: The Development and Deployment of Assisted and Autonomous Care Options

Abstract The applications of artificial intelligence (AI) in perioperative cardiothoracic and vascular practice continue to grow, given its multiple applications from discovery across translation and integration to delivery of clinical..

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Delirium after Coronary Artery Bypass Grafting: Where We Are Now and Setting Goals for Where We Could Go Next

Abstract Delirium remains a common yet important complication after coronary artery bypass grafting (CABG)., Despite robust research linking delirium to adverse outcomes in this setting, it is still regarded as a..

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Rethinking paracorporeal lung assist device support in the modern era: Why so different than ECMO?

Abstract Background Pediatric patients with combined irreversible pulmonary disease and right ventricular (RV) failure on conventional ECMO face significant challenges with rehabilitation and transplant candidacy. We describe our institutional experience..

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Early Prediction of Neurological Outcome After Cardiac Arrest-Rationale and Design of the Prospective International Observational EARLY-NEURO, a STEPCARE Substudy

Abstract Background Guidelines discourage prediction of neurological outcome in comatose patients within the first 72 h after cardiac arrest. Increasing evidence suggests that patients with the most severe brain injury and..

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Biomechanical anticoagulation by spherical platelets in extracorporeal systems

Abstract Extracorporeal life support, such as hemodialysis, often face the risk of blood coagulation, where systemic anticoagulation with heparin is routinely administered. However, this strategy is contraindicated in patients at..

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The global burden of cardiovascular disease in adults: A mapping review

Abstract The global burden of cardiovascular diseases (CVDs) in adults is increasing. Over the past several decades, CVDs have remained the leading cause of death worldwide. Among CVDs, most mortality..

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Perioperative multivariate analysis and risk prediction of acute kidney injury after cardiac surgery: Based on dynamic temperature changes during cardiopulmonary…

Abstract Background Temperature variations during  (CPB) may significantly contribute to the development and progression of  (AKI) after cardiac surgery. We tested the hypothesis that temperature time-series variables during CPB are associated with..

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NAVA use in infants with established bronchopulmonary dysplasia, congenital diaphragmatic hernia, and those on ECMO: a narrative literature review

Abstract Neurally Adjusted Ventilatory Assist (NAVA) is an innovative mode of ventilation that delivers support in synchrony with the infant’s diaphragmatic electrical activity. This technology aims to improve patient–ventilator interaction,..

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Factor XII in Thrombosis and Thromboinflammation: From Molecular Biology to Clinical Translation

Abstract Factor XII (FXII) is a central mediator at the intersection of coagulation, fibrinolysis, inflammation, and immunity. It is activated upon contact with negatively charged surfaces, triggering the intrinsic coagulation..

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Anaemia: A Scientific Overview on Types and Recent Advancements in the Detection of Anaemia

Abstract Anaemia is the term for low red blood cell numbers or a deficiency of hemoglobin, the protein that carries oxygen in red blood cells. This results in a reduction..

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