Tags Archives: vasoplegia

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Definitions for Vasoplegia Associated With On-Pump Cardiac Surgery: A Systematic Review With Meta-Analysis

Abstract OBJECTIVES:  Vasoplegia is a common complication of cardiac surgery that uses cardiopulmonary bypass and contributes to morbidity and mortality, yet a consensus definition does not exist. The objective of..

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Targeting the contributors to vasorelaxation during vasoplegia from cardiopulmonary bypass

Abstract Vasoplegia, a syndrome of noncardiogenic, non-hypovolaemic vasodilatory hypotension is a common complication of cardiac surgery utilising cardiopulmonary bypass. Vasopressor-sparing strategies have been increasingly used in the management of vasoplegia..

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Hydroxocobalamin for vasoplegia in cardiac surgery: a retrospective cohort analysis

Abstract Background Vasoplegia during cardiac surgery is common and associated with perioperative mortality. Hydroxocobalamin is a catecholamine-sparing approach for treating vasoplegia. However, there is currently limited evidence to inform its..

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Vasoplegia Syndrome After Cardiac Surgery: Insights Into Mechanisms and Treatment

Abstract Vasoplegia syndrome is a specific form of vasodilatory shock encountered in patients who undergo cardiac surgery, most commonly with cardiopulmonary bypass, which is characterized by severe hypotension in the..

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The Efficacy and Safety of Angiotensin II for Treatment of Vasoplegia in Critically Ill Patients: A Systematic Review

Abstract Objectives To summarize evidence regarding intravenous angiotensin II administration in critical illness and provide an updated understanding of its effects on various organ dysfunction and renin-angiotensin system (RAS) biomarkers...

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Vasoplegia in Cardiac Surgery: A Systematic Review and Meta-analysis of Current Definitions and Their Influence on Clinical Outcomes

Abstract Objectives To identify differences in the reported vasoplegia incidence, intensive care unit (ICU) length of stay (LOS), and 30-day mortality rates as influenced by different vasoplegia definitions used in..

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Vasoplegic Syndrome Following Bypass: A Comprehensive Review of Pathophysiology and Proposed Treatments

Abstract Following cardiopulmonary bypass (CPB) surgery, patients may experience vasoplegic or vasogenic shock syndrome. This condition has a variable incidence, reaching up to 44% in high-risk patients, with mortality rates..

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Vasoplegia: Mechanism and Management Following Cardiopulmonary Bypass

Abstract Vasoplegia is defined by hypotension and low systemic vascular resistance despite the normal or elevated cardiac index, a complication frequently following cardiac surgery, carrying high morbidity and mortality rate...

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Vasoplegia is Predicted by Preoperative Platelet-Leucocyte conglomerate Indices in Cardiac Surgery (VASOPLEGICS): A retrospective single-center study

Abstract Background: Post-cardiotomy vasoplegia syndrome (VS) is often linked to an exaggerated inflammatory response to cardiopulmonary bypass (CPB). At the same time, the prognostic role of platelet-leucocyte indices (PLIs) and leucocyte..

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A Review of Pulmonary Arterial Hypertension Treatment in Extracorporeal Membrane Oxygenation: A Case Series of Adult Patients

Abstract Background: Little data is published describing the use of medications prescribed for pulmonary arterial hypertension (PAH) in patients receiving extracorporeal membrane oxygenation (ECMO). Even though many patients with PAH..

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Defining vasoplegia following durable, continuous flow left ventricular assist device implantation

Abstract This study aimed to develop a definition of vasoplegia that reliably predicts clinical outcomes. Vasoplegia was evaluated using data from the electronic health record for each 15-minute interval for..

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Methylene Blue for Vasoplegia During Extracorporeal Membrane Oxygenation Support

Abstract Objective The treatment of refractory vasodilatory shock in patients undergoing  (ECMO) is an area in which there is minimal literature. Based on previous literature, the authors hypothesized that at least..

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Risk factors for vasoplegia after coronary artery bypass and valve surgery

Abstract Introduction Vasoplegia denotes a state of low tissue perfusion characterized by hypotension, tachycardia, and low systemic vascular resistance. This state results in increased mortality and morbidity following cardiac surgery...

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Vasoplegic syndrome and its treatment with vasopressin during cardiac surgery with cardiopulmonary bypass

Abstract Cardiac surgery with cardiopulmonary bypass is associated with systemic inflammatory response. In some cases this clinical condition is characterized by severe hypotension due to low systemic vascular resistance during..

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Cirugía cardiaca con circulación extracorpórea: síndrome vasoplégico y vasopresina

La cirugía cardiaca con circulación extracorpórea (CEC) se acompaña de una respuesta inflamatoria sistémica, caracterizada por vasodilatación y por disminución de la resistencia vascular sistémica (RVS). Esta condición patológica se..

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Methylene Blue for Vasoplegia When on Cardiopulmonary Bypass During Double-Lung Transplantation

Abstract Vasoplegia syndrome, characterized by hypotension refractory to fluid resuscitation or high-dose vasopressors, low systemic vascular resistance, and normal-to-increased cardiac index, is associated with increased morbidity and mortality after cardiothoracic..

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Altered kinetics of circulating progenitor cells in cardiopulmonary bypass (CPB) associated vasoplegic patients: A pilot study

Abstract Vasoplegia observed post cardiopulmonary bypass (CPB) is associated with substantial morbidity, multiple organ failure and mortality. Circulating counts of hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPC) are..

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A Pilot, Double-Blind, Randomized, Controlled Trial of High-Dose Intravenous Vitamin C for Vasoplegia After Cardiac Surgery

Abstract Objective To conduct a pilot feasibility and physiologic efficacy study of high-dose vitamin C in patients with vasoplegia after cardiac surgery. Design Prospective, double-blind, randomized, controlled trial. Setting Two..

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Mechanisms of vascular hyporesponsiveness in septic shock

Abstract Purpose: To define some of the most common characteristics of vascular hyporesponsiveness to catecholamines during septic shock and outline current therapeutic approaches and future perspectives. Methods: Source data were obtained from..

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Vasoplegia treatments: the past, the present, and the future

Abstract Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic, cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving various mechanisms in vascular smooth muscle cells..

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