Tags Archives: Sepsis

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Extracorporeal Cytokine Adsorption in Sepsis: Current Evidence and Future Perspectives

Abstract Background: Sepsis and septic shock are major contributors to global morbidity and mortality. The “cytokine storm,” a hyper-inflammatory response, plays a central role in sepsis pathophysiology, leading to multi-organ..

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Flow of Data, Not Blood Flow, Is the Key to Unraveling ECMO Support in Mixed Shock

Abstract Mixed shock has been identified by the Shock Academic Research Consortium (SHARC) as a “high-risk, understudied population”. It develops in around one-quarter of patients with cardiogenic shock and has a higher..

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The Role of Venoarterial Ecmo in the Management of Sepsis-Induced Cardiomyopathy and Refractory Shock: An Analytic Review

Abstract Sepsis-induced cardiomyopathy is a severe complication seen in patients with refractory septic shock, characterized by cardiac dysfunction due to an overwhelming inflammatory response secondary to infection. Despite its reversible..

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Sepsis-Extracorporeal Membrane Oxygenation Score in Patients Receiving Extracorporeal Membrane Oxygenation Support for Sepsis

Abstract Predictive scoring systems for adult patients receiving extracorporeal membrane oxygenation (ECMO) support for sepsis have not been yet reported. Based on the Chinese Society of ExtraCorporeal Life Support (CSECLS)..

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Use of extracorporeal blood purification therapies in sepsis: the current paradigm, available evidence, and future perspectives

Abstract Background Sepsis is the result of a dysregulated immune response to infection and is associated with acute organdysfunction. The syndrome’s complexity is contingent upon the underlying pathology and individual..

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Hemodynamic Support in Sepsis

Abstract Sepsis is a dysregulated host response to infection responsible for life-threatening organ dysfunction.1  Along with early antimicrobial administration and source control, correction of hemodynamic derangements is a crucial aspect of..

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Sepsis-Induced Coagulopathy: A Comprehensive Narrative Review of Pathophysiology, Clinical Presentation, Diagnosis, and Management Strategies

Abstract Physiological hemostasis is a balance between pro- and anticoagulant pathways, and in sepsis, this equilibrium is disturbed, resulting in systemic thrombin generation, impaired anticoagulant activity, and suppression of fibrinolysis,..

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Sepsis in cardiothoracic surgery

Abstract Sepsis is a life-changing condition that can occur  undergoing . It is characterized by a dysregulated inflammatory response to infection, often leading to higher rates of organ dysfunction and mortality. The..

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Tachycardia in Sepsis: Friend or Foe?

Abstract Sepsis and Tachycardia – Aetiologic Factors During sepsis, the sympathetic nervous system plays a key role in maintaining cardiac output and blood pressure. This is achieved through changes in..

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Use of CytoSorb as a stand-alone therapy in a patient suffering from sepsis and multiple organ dysfunction

This case reports on a 67-year-old male patient, who was admitted to hospital suffering from a severe immunological response following his 2nd COVID-19 vaccination. [pdf-embedder url="https://perfusfind.com/wp-content/uploads/2022/05/CoW_19_2022_E_web_compressed.pdf"]

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Measuring the Resting Energy Expenditure in Children on Extracorporeal Membrane Oxygenation: A Prospective Pilot Study

Abstract Both overfeeding and underfeeding critically ill children are problematic. This prospective pilot study evaluated the resting energy expenditure in infants and children requiring extracorporeal membrane oxygenation (ECMO) support. An..

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Outcomes of Pediatric Patients With Sepsis Related to Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus Infections Requiring Extracorporeal Life Support: An…

Abstract Background: Extracorporeal membrane oxygenation (ECMO) is increasingly utilized for pediatric sepsis unresponsive to steroids and inotropic support. Outcomes of children with sepsis are influenced by the type of pathogen causing..

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Clinical Guidelines for Adult Heart Transplantation British Columbia

Abstract Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection [1]. Sepsis and septic shock are major healthcare problems, impacting millions of people around the world..

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Neurological Outcome According to the Site of Cannulation in Septic Children Supported by Venoarterial Extracorporeal Membrane Oxygenation

Abstract The impact of cervical cannulation on neurologic outcome has not been yet studied among children receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) in the context of severe sepsis or septic..

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Extracorporeal Cytokine Adsorption Therapy As a Preventive Measure in Cardiac Surgery and As a Therapeutic Add-On Treatment in Sepsis

Abstract Objectives:  Evaluating whether there is a clinical benefit of using extracorporeal cytokine adsorption therapy in two indications. Design:  Systematic review. Setting:  Search on four databases, Medline, Embase, The Cochrane..

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The diagnostic accuracy of procalcitonin in infectious patients after cardiac surgery: a systematic review and meta-analysis

Abstract Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute inflammatory response that may lead to a systemic inflammatory response syndrome. The interest in procalcitonin (PCT) in the diagnosis of..

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Hemoadsorption with CytoSorb in Septic Shock Reduces Catecholamine Requirements and In-Hospital Mortality: A Single-Center Retrospective ‘Genetic’ Matched Analysis

Abstract Septic shock is a major burden to healthcare with mortality rates remaining high. Blood purification techniques aim to reduce cytokine levels and resultant organ failure. Regarding septic shock, hemoadsorption..

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The role of red blood cells and cell-free hemoglobin in the pathogenesis of ARDS

Abstract The primary focus of research into the pathophysiology of the acute respiratory distress syndrome (ARDS) has been on the interaction between the lung, underlying causes of ARDS, and the..

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Predictors of survival in adults undergoing extracorporeal membrane oxygenation with severe infections

Abstract Background To identify novel factors associated with the survival of septic adults receiving  (ECMO) to improve patient selection and outcomes. Methods Cases were identified from our ECMO registry from 2001..

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Hemoadsorption during Cardiopulmonary Bypass in Patients with Endocarditis Undergoing Valve Surgery: A Retrospective Single-Center Study

Abstract Background: Aim of this study was to evaluate the outcomes of endocarditis patients undergoing valve surgery with the Cytosorb® hemoadsorption (HA) device during cardiopulmonary bypass. Methods: From 2009 until 2019,..

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Serum lactate poorly predicts central venous oxygen saturation in critically ill patients: a retrospective cohort study

Abstract Background Serum lactate and central venous oxygen saturation (ScvO2) are commonly used and commonly recommended as markers of tissue oxygenation in shock states. Medical literature has both explicitly stated..

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Most Deaths in Low-Risk Cardiac Surgery Could Be Avoidable

Abstract It is observed that death rates in cardiac surgery has decreased, however, root causes that behave like triggers of potentially avoidable deaths (AD), especially in low-risk patients (less bias)..

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Glycocalyx and its involvement in clinical pathophysiologies

Abstract Vascular hyperpermeability is a frequent intractable feature involved in a wide range of diseases in the intensive care unit. The glycocalyx (GCX) seemingly plays a key role to control..

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