Abstract Thrombin generation (TG) is reduced after cardiac surgery using cardiopulmonary bypass (CPB), contributing to coagulopathy and bleeding. Plasma transfusion or four-factor prothrombin complex concentrate (PCC) are commonly used to..
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Abstract Objective This study aims to compare the efficacy and safety of activated recombinant factor VII (rFVIIa) and prothrombin complex concentrate (PCC) in the treatment of bleeding complications following surgery..
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Abstract Background Treatment of significant coagulopathic cardiac surgical field bleeding with immediate higher-dose (PCC) without (FFP) or is unexplored. Aims To study characteristics, , and clinical outcomes of patients with significant coagulopathic surgical field..
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Abstract Importance Post–cardiopulmonary bypass (CPB) coagulopathy and bleeding are among the most common reasons for blood product transfusion in surgical practices. Current retrospective data suggest lower transfusion rates and blood loss..
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Abstract Purpose of review Major bleeding in cardiac surgery is commonly encountered, and, until recently, most frequently managed with fresh frozen plasma (FFP). However, a Cochrane review found this practice..
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Abstract Objectives (PCCs) are used to rapidly reverse by oral . They differ in the content of , endogenous anticoagulants, and heparin. The authors hypothesized that PCCs’ specific heparin content may compromise the effect...
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