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An overview of cell salvage in orthopaedic hip and knee arthroplasty surgery

Abstract Blood management is a critical aspect of patient care during surgical procedures. In the United Kingdom, there is a growing recognition of the need to integrate intraoperative cell salvage..

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Enhancing Glucose Uptake as a Means to Protect the Heart During Cardiopulmonary Bypass or Ischemia–Reperfusion InjuryEnhancing Glucose Uptake as a…

Abstract Chen et al. used a rat model of cardiopulmonary bypass followed by 30-min ischemia (induced by ascending aorta blockage) and 15-min reperfusion []. They reported that pyruvate dehydrogenase E1α..

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Moderate hypothermia circulatory arrest as a brain-protective strategy for type A aortic dissection

Abstract OBJECTIVES Brain-protective strategies for acute type A aortic dissection (TAAD) remain controversial. Moderate hypothermia circulatory arrest (MHCA) without cerebral perfusion is not commonly used. However, we aimed to assess..

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Predictive role of cardiopulmonary bypass exposure indexed to body surface area on postoperative organ dysfunction: a retrospective cohort study

Abstract OBJECTIVES Long cardiopulmonary bypass times are associated with adverse postoperative outcomes and increased healthcare resource use. It is likely that this effect is pronounced in smaller patients. Previous studies..

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Ambulation in patients with peripheral veno-arterial extracorporeal membrane oxygenation and concomitant femoral intra-aortic balloon pump support

Abstract Introduction The mobilization and ambulation of patients with severe cardiogenic shock supported with peripheral veno-arterial extracorporeal membrane oxygenation (pVA-ECMO) and concomitant femoral intra-aortic balloon pump (IABP) support is not..

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Multiscale structure and function of the aortic valve apparatus

Abstract Whereas studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital..

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Neurological Complications Following Cardiac Surgery: Management and Future Directions

Abstract Neurological complications related to cardiac surgery present physicians with challenges. These complications severely impact patients’ outcomes, the quality of their lives, and affect the resources available at healthcare centers...

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Modeling the effect of patient size on cerebral perfusion during veno-arterial extracorporeal membrane oxygenation

Abstract Introduction A well-known complication of veno-arterial extracorporeal membrane oxygenation (VA ECMO) is differential hypoxia, in which poorly-oxygenated blood ejected from the left ventricle mixes with and displaces well-oxygenated blood..

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Hematocrit and Renal Failure in Aortic Arch Surgery: A Society of Thoracic Surgeons Database Study

Abstract Background This study examined the association between cardiopulmonary bypass (CPB) hematocrit and postoperative acute renal failure (ARF) in patients undergoing aortic arch surgery with hypothermic circulatory arrest. Methods The..

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A systematic review of variability in the reporting of extracorporeal membrane oxygenation-associated infections and recommendations for standardization

Abstract Background Extracorporeal membrane oxygenation (ECMO) utilization has surged in recent years, particularly amidst the COVID-19 pandemic, yet standardization of ECMO-associated infection (EAI) reporting remains lacking. Methods This systematic review..

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Differential hypoxemia during peripheral cardiopulmonary bypass

Abstract Introduction Minimally invasive cardiac surgery (MICS) for mitral valve repair often uses cardiopulmonary bypass (CPB) through peripheral femoro-femoral cannulation. A rare complication of differential hypoxemia can cause upper body..

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Pharmacokinetic Research in Pediatric Extracorporeal Therapies: Current State and Future Directions

Abstract Extracorporeal life support (ECLS), including extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT), is a lifesaving therapy for critically ill children. Despite this, these modalities carry frustratingly..

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Practical considerations on hypoxemia and hypoxia in V-V ECMO patients

Abstract We would like to express our gratitude to Aravind Bommiasamy and his coauthors for their detailed analysis on the physiological impacts of cardiac output (CO) on oxygen supply in..

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Mapping the Human Cell Surface Interactome: A Key to Decode Cell-to-Cell Communication

Abstract Proteins on the surfaces of cells serve as physical connection points to bridge one cell with another, enabling direct communication between cells and cohesive structure. As biomedical research makes..

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Association Between Cerebral Microbleeds and Neurological Outcomes in Patients Who Underwent Extracorporeal Membrane Oxygenation

Abstract Background Cerebral microbleeds (CMBs) are common and varied in patients receiving extracorporeal membrane oxygenation (ECMO). Here, the authors describe CMB findings in patients receiving ECMO and their association with..

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Pitfalls of reasoning in hospital-based transfusion medicine

Abstract Introduction Hospital-based transfusion involves hundreds of daily medical decisions. Medical decision-making under uncertainty is susceptible to cognitive biases which can lead to systematic errors of reasoning and suboptimal patient..

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Anaphylactic Reaction to Protamine Sulfate: A Case Report

Abstract Protamine sulfate is a standard agent used to reverse heparin anticoagulation during cardiovascular procedures such as coronary artery bypass grafting (CABG). Although rare, it can be associated with severe..

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Is there still a place for ECCO2R?

Abstract The therapeutic target of extracorporeal carbon dioxide removal (ECCO2R) is the elimination of carbon dioxide (CO2) from the blood across a gas exchange membrane without influencing oxygenation to a clinically relevant..

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A Retrospective Multicenter Study of Operating Room Extubation and Extubation Timing following Cardiac Surgery

Abstract Background In an effort to enhance recovery after cardiac surgery, intraoperative extubation has been targeted as possibly beneficial. This multi-center cohort study aimed to assess this by evaluating the outcomes..

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Giant Pheochromocytoma Resection Using Partial Cardiopulmonary Bypass and Blood Purification Therapy

Abstract A 44-year-old man was diagnosed with a giant pheochromocytoma in the right retroperitoneal cavity following treatment for heart failure. Subsequent to improvement in cardiac function, the patient underwent a..

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Review of Interleukin-6 and Cardiopulmonary Bypass-Related End-Organ Injury Along With the Potential for Mitigation With Tocilizumab

Abstract Cardiopulmonary bypass (CPB) is essential for the conduct of open-heart procedures. While lifesaving, CPB can be associated with significant end-organ injuries believed to result from inflammatory responses triggered by..

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Risk of Postoperative Hypermagnesemia in Cardiopulmonary Bypass Assisted Cardiovascular Surgery

Abstract Background:  Magnesium administration is a common practice in cardiovascular surgeries utilizing cardiopulmonary bypass (CPB). However, concerns persist regarding the risk of hypermagnesemia, particularly in patients with kidney dysfunction. This..

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Combined effect of anion gap and red cell distribution width on the risk of acute kidney injury after cardiac surgery

Abstract Background This study was to analyze the roles of red blood cell distribution width (RDW), anion gap (AG) levels and their combined effects on the risk of acute kidney..

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Prediction of Thrombus Formation within an Oxygenator via Bioimpedance Analysis

Abstract Established clinical monitoring techniques lack predictive capabilities, emphasizing the need for refinement in MO monitoring towards an early warning system. In this study, an MO was modified by integrating..

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CO2 delivery techniques in mini-sternotomy surgery and neurological events: a multicentric study

Abstract Background The impact of air bubbles into the cerebral circulation after open heart surgery has been a topic of discussion since the introduction of the heart-lung machine. The aim..

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Hydroxocobalamin Versus Methylene Blue for Treatment of Vasoplegic Shock Following Cardiopulmonary Bypass: A Systematic Review and Meta-analysis

Abstract Objectives To summarize the evidence of the hemodynamic effects and vasopressor requirements of adult cardiac surgery patients with vasoplegic shock treated with hydroxocobalamin or methylene blue. Design Systematic review..

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Association of Activated Clotting Time–Guided Anticoagulation with Complications during Extracorporeal Membrane Oxygenation Support: A Systematic Review and Meta-Analysis

Abstract Objective Extracorporeal membrane oxygenation (ECMO) requires systemic anticoagulation to reduce the risk of thromboembolic events. Despite its historic role, activated clotting time (ACT) remains a widely used heparin monitoring..

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Age as a Mortality Predictor in ECPR Patients

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) is an advanced technique using extracorporeal membrane oxygenation (ECMO) to support patients with refractory cardiac arrest. Age significantly influences ECPR outcomes, with younger patients generally..

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The effect of mannitol on postoperative renal function in patients undergoing coronary artery bypass surgery: A double-blinded randomized controlled trial

Abstract Introduction: Mannitol, an osmotic diuretic solution, is commonly utilized in priming cardiopulmonary bypass (CPB) and can impact kidney function. This study was conducted to investigate the impact of mannitol use..

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Prophylactic corticosteroids for infants undergoing cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis of randomized controlled trials

Abstract Background Prophylactic corticosteroids have been widely used to mitigate the inflammatory response induced by cardiopulmonary bypass (CPB). However, the impact of this treatment on clinically important outcomes in infants..

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