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Timing of venoarterial extracorporeal membrane oxygenation in infant cardiac surgery: a single-centre retrospective study of clinical outcomes

Abstract Background Venoarterial extracorporeal membrane oxygenation (VA ECMO) is a critical therapeutic intervention that is commonly used in the management of paediatric patients with congenital heart disease (CHD). This procedure..

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Battlefield mechanical ventilation and extracorporeal membrane oxygenation: A scoping review

Abstract Background Casualties of military conflicts suffer a multitude of injuries, and recent research has documented a significant number develop acute respiratory distress syndrome (ARDS). The present study undertakes a..

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Predictors and outcomes in patients undergoing surgery for acute type A aortic dissection requiring concomitant venoarterial extracorporeal membrane oxygenation support—a…

Abstract OBJECTIVES The study’s aim was to investigate the outcomes and risk factors for mortality in patients undergoing surgery for acute type A aortic dissection receiving concomitant venoarterial extracorporeal membrane..

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Synthetic colloids as priming fluids in cardiopulmonary bypass and postoperative acute kidney injury: a propensity score-matched study

Abstract Background The optimal fluid management strategy for patients undergoing on-pump cardiac surgery was controversial regarding the fluid types. This study aimed to compare the impact of hydroxyethyl starch (HES)..

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Early endovascular reperfusion during extracorporeal support for massive pulmonary embolism

Abstract In massive pulmonary embolism (PE), endovascular therapies and extracorporeal membrane oxygenation (ECMO) are increasingly utilised. However, the impact of combining endovascular therapies with ECMO on shock resolution and clinical recovery remains..

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Variations in thromboelastography levels in blood exposed to membrane oxygenators

Abstract Introduction Thromboelastography (TEG), which indicates hemostatic ability, is useful for monitoring coagulation during extracorporeal circulation (ECC). However, the extent to which TEG levels are independently affected by ECC exposure..

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Population-Scale Studies of Protein S Abnormalities and Thrombosis

Abstract Importance  Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an..

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Effect of blood conservation protocol on the utilisation of blood and outcome of patients undergoing open heart surgery

Abstract Introduction Cardiac surgery is fraught with increased consumption of blood and blood products. Various strategies for blood conservation have been described. Our aim was to study the impact of..

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Assessing the environmental impact of coronary artery bypass grafting to decrease its footprint

Abstract OBJECTIVES An urgent transition to environmentally sustainable healthcare is required. The purpose of this study was to identify key areas for environmental impact mitigation for a coronary artery bypass..

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Pioneering MiECC in Pakistan: First Experience at Punjab Institute of Cardiology

Introduction Cardiopulmonary bypass (CPB) has long been a cornerstone of cardiac surgery. However, conventional CPB circuits are associated with a range of physiological disturbances including hemodilution, inflammatory response, and coagulopathy...

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The Interplay Between and Among Various Participants Within the Cardiac Surgical Team

Introduction Cardiac surgery is a highly specialized and complex field that requires the seamless coordination of multiple professionals, each bringing their expertise to ensure a successful outcome. The success of..

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Theoretical Foundations of Cardiopulmonary Bypass: Bridging Science, Engineering, and Clinical Practice

Introduction: A Heart That Pauses, A Circuit That Lives When the heart is arrested during cardiac surgery, life continues—thanks to cardiopulmonary bypass (CPB). The theoretical underpinnings of CPB stem from..

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The Ethical, Professional, and Legal Implications of Perfusion Practice: A Global and Developing Country Perspective

Abstract Perfusionists are central to life-sustaining interventions such as cardiopulmonary bypass (CPB), extracorporeal membrane oxygenation (ECMO), and mechanical circulatory support. While the technical dimensions of their work are well recognized,..

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Post-pericardiectomy ECMO for constrictive pericarditis: a case series and literature review

Abstract Background Pericardiectomy is the curative treatment for constrictive pericarditis, yet postoperative low cardiac output syndrome (LCOS) may occur. The application of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in post-pericardiectomy refractory..

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Personalized strategies for high-risk acute pulmonary embolism: addressing the “catastrophic” subgroup

Abstract We read with great interest the recent study by Stadlbauer  et al. [1] published in Intensive Care Medicine, which  evaluates the impact of reperfusion therapy including  systemic thrombolysis (SYS), surgical..

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Predictive value of the triglyceride-glucose index for coronary artery bypass grafting-acute kidney injury patients

Abstract Background Acute kidney injury (AKI) is a common and serious complication after coronary artery bypass grafting (CABG), significantly affecting patient outcomes. The triglyceride-glucose (TyG) index, a marker of insulin..

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Incidence and Risk Factors of Cannula-Associated Deep Vein Thrombosis After Extracorporeal Life Support in Adult Critically Ill Patients

Abstract Cannula-associated deep vein thrombosis (CaDVT) following decannulation from extracorporeal life support (ECLS) is a commonly reported complication with several associated risk factors. This study investigated the incidence and risk..

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Rising Above the Limits of Critical Care ECMO: A Narrative Review

Abstract Extracorporeal membrane oxygenation (ECMO), an advanced life support method, was developed to treat severe cardiac and pulmonary failure in critically ill patients. ECMO was previously used to treat ARDS,..

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Use of Inhaled Tranexamic Acid for Pulmonary Hemorrhage in Pediatric Patients on Extracorporeal Membrane Oxygenation Support

Abstract Bleeding is a common complication of extracorporeal membrane oxygenation (ECMO), is multifactorial, and results in significant morbidity and mortality. Pulmonary hemorrhage represents a serious adverse event in pediatric patients..

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Outcomes after extracorporeal membrane oxygenation for the treatment of high-risk pulmonary embolism: a multicentre series of 52 cases

Abstract Aims The role of extracorporeal membrane oxygenation (ECMO) remains ill defined in pulmonary embolism (PE). We investigated outcomes in patients with high-risk PE undergoing ECMO according to initial therapeutic..

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Evaluation of hemolysis in patients supported with Impella 5.5: a single center experience

Abstract Background Hemolysis, variably defined in mechanical circulatory support (MCS), is understudied in percutaneous left ventricular assist devices. We characterize hemolytic sequelae of Impella 5.5-supported patients in the largest series..

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Micronanoplastic exposure due to cardiopulmonary bypass in children: A prospective observational study

Abstract Cardiopulmonary bypass (CPB) is widely used in cardiac operations. However, it remains unclear whether a CPB circuit, which is mainly made of plastics, can release micronanoplastics (MNPs) into the..

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Recent Advances and Future Directions in Extracorporeal Carbon Dioxide Removal

Abstract Extracorporeal carbon dioxide removal (ECCO2R) is an emerging technique designed to reduce carbon dioxide (CO2) levels in venous blood while enabling lung-protective ventilation or alleviating the work of breathing...

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Mesenteric Ischemia During Intra-Aortic Balloon Counterpulsation Therapy: Case Series

Abstract Intra-aortic balloon pumps (IABPs) are commonly used circulatory support devices. Mesenteric ischemia is a serious and poorly studied complication of IABP use. Here, we examine six cases of mesenteric..

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Impact of extracorporeal blood pump gap sizes on the performance and hemocompatibility under off-design operation

Abstract Background Hemocompatibility remains the dominant challenge in rotary blood pumps, and more information on the relationship between individual pump design features, hemodynamics, and blood trauma in various operation conditions..

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How Red Blood Cells Sense and Respond to Mechanical Stress

Abstract “Mechanotransduction” is a term I would use to describe my research topic, and it works perfectly well, as long as the goal is to earn confused looks and immediately..

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The 2024 international survey of platelet products and practice

Abstract Background Previously, two international surveys have addressed the wider application of platelet collection by apheresis technology and practical issues of platelet transfusion. Study design and methods A questionnaire was..

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High-risk pulmonary embolism: thesignificance and perspectives of pulmonaryreperfusion

Abstract Rapid hemodynamic stabilization and restoration of pulmonary perfusion are the cornerstones of treatment for high-risk pulmonary embolism (PE). While all current guidelines recommend systemic thrombolysis (SYS) as the first-line..

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The Role of Continuous Monitoring of Venous Drainage Flow and Integrated Oxygen Extraction (ERiO2) via Bilateral Near-Infrared Spectroscopy in Cerebral…

Abstract Background and Objective:  Effective cerebral perfusion monitoring is essential in aortic arch surgery, particularly when employing the Kazui technique under moderate hypothermia. Near-infrared spectroscopy (NIRS) provides real-time regional oxygen..

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Blood conservation strategies in complex aortic surgery for a Jehovah’s Witness: A case report

Abstract Introduction: Complex aortic surgery involving Jehovah’s Witness patients presents a significant challenge due to their refusal of blood products.   Case report: This case report details the management of..

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