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Hematocrit and total protein elimination as quality control parameters of cell salvage

Abstract Background:   The use of cell salvage reduces homologous blood transfusions during operations and avoids associated complications. Therefore, autotransfusion is an integral part of Patient Blood Management (PBM). The..

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Investigation of contamination and environmental exposure of cold/heated water supply systems for extracorporeal circulation used in ECMO and other applications

Abstract Infection cases have been reported where Legionella spp. and NTM (non-tuberculous mycobacteria) increased due to the contamination of circulating water in cold/heated water supply systems for extracorporeal circulation used in cardiac..

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New Findings on Pulsatile ECMO: Verification of the Potential to Improve Antithrombogenicity of a Membrane Oxygenator Using Pump-Generated Pulsatile Flow…

Abstract Background Extracorporeal membrane oxygenation (ECMO) provides mechanical circulatory and respiratory support. However, thrombus formation in the circuit can lead to hemorrhagic complications, requiring improvements in ECMO anti-thrombogenicity. Few studies..

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Refractory anaphylactic shock to peanut ingestion in a pediatric patient requiring extracorporeal life support

Abstract Introduction Current guidelines advise that anaphylactic shock refractory to traditional treatments may be managed with extracorporeal life support (ECLS), but reports have been exclusive to adults. Case Report We..

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Comparative analysis of perioperative outcomes between hybrid system and MiECC: A prospective pilot study

Abstract Background: Minimally invasive extracorporeal circulation (MiECC) has been introduced to mitigate the inflammatory response and reduce blood transfusion needs compared to conventional cardiopulmonary bypass (CPB) perioperatively. A hybrid system..

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Successful Treatment of Extracorporeal Membrane Oxygenation Induced Digital Ischemia in Infants Using Botulinum Toxin Type A

Abstract Digital ischemia following extracorporeal membrane oxygenation (ECMO) therapy is a known complication with potential devastating long-term sequela. Onabotulinum toxin type A (BTX-A) has been demonstrated to be effective for..

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The Effect of Hypotension on Cerebral Metabolism and Perfusion in Adults Undergoing Cardiopulmonary Bypass: A Prospective Cohort Study

Abstract BACKGROUND:  Current blood pressure management strategies cannot accommodate large interindividual variations in cerebral autoregulation, which may result in inadvertent cerebral ischemia. A novel optical neuromonitoring device was developed to..

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CPR-induced consciousness in hypothermic cardiac arrest: Where is the limit of tolerance of the human brain? A case report

Abstract BackgroundCPR-induced consciousness (CPRIC) is defined as consciousness during CPR, ranging from eye opening to combative behaviour and vocalisation, despite the absence of spontaneous circulation. CPRIC has not previously been..

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Clinical evaluation of SafeCEC® one-way valve in hemolysis during CPB: Pilot study

Abstract Introduction: In cardiopulmonary bypass (CPB), blood circulation is temporarily maintained by an artificial blood-pumping device during cardiac surgery. Worldwide, approximately half of the CPB procedures utilize either centrifugal or..

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Minimally invasive, transapical dual-lumened cannula for short-term left ventricular support in a clinically relevant large animal model†

Abstract OBJECTIVES Cardiogenic shock is still a major clinical challenge, despite the available devices. We developed a minimally invasive, transapical dual-lumened cannula, which can provide antegrade circulatory support and unloading..

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The protective effect of pulmonary artery infusion with HTK solution on the lungs during prolonged cardiopulmonary bypass surgery

Abstract Background Studies have proved that artery infusion during CPB operations can reduce lung injury led by CPB surgery. This study was undertaken to investigate the effects of HTK solution..

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The 10 Commandments of On-Table Extubation After Cardiac Surgery: Why and How to Increase Adoption

Abstract Introduction It is around 4 PM when the surgeon, having just transferred his afternoon theater patient to the intensive care unit (ICU), approaches the patient’s family with a reassuring..

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On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death

Abstract Cardiac allotransplantation is warranted in children with end-stage heart failure or irreparable congenital heart disease. A dearth of organs for transplantation has contributed to long wait-list times and resultant..

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Assisted artificial intelligence in medical writing: a primer for humans

Abstract Assisted artificial intelligence (A-AI) has rapidly become a gold standard approach for conducting data analysis and medical writing []. From executing complex statistical tasks to extracting relevant information and..

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Technique of Intra-Aortic Balloon Pump Insertion Through Axillary Artery Over a Chimney Graft

Abstract Intra-aortic balloon pump (IABP), which augments coronary blood flow and reduces cardiac afterload, is the most widely used temporary mechanical circulatory support (TMCS) device. It has been used in..

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Is hyperoxia in early pediatric veno-veno extracorporeal life support associated with mortality?

Abstract Background: Data is limited regarding the effects of supraphysiologic blood oxygen tension (hyperoxia) in patients requiring extracorporeal life support (ECLS). We sought to evaluate the association between hyperoxia and..

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Time-dose response of oxygen delivery during cardiopulmonary bypass in mitral valve surgery: does surgical approach matter?

Abstract Introduction Increased time-dose-response (TDR) of suboptimal oxygen delivery (DO2) during cardiopulmonary bypass (CPB) has been associated with increased postoperative complications. The impact of surgical approach - minimally invasive vs...

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Randomized Trials in Cardiac Surgery: Why and How

Abstract OBJECTIVES Randomized clinical trials (RCTs) are the gold standard for comparative effectiveness. However, they face unique challenges in cardiac surgery. The objective of this work is to summarize the..

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Efficacy of hemadsorption combining with cardiopulmonary bypass used in patients with acute type A aortic dissection

Abstract Background It is hypothesized that combining HA380 with cardiopulmonary bypass (CPB) in acute type A aortic dissection (ATAAD) surgery could reduce the inflammatory response induced by CPB and subsequently..

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Unilateral Versus Bilateral Antegrade Cerebral Perfusion in Aortic Arch Surgery: Systematic Review and Meta-Analysis of Randomised Controlled Trials and Propensity-Matched…

Abstract Background Selective antegrade cerebral perfusion, via unilateral antegrade cerebral perfusion (uACP) or bilateral antegrade cerebral perfusion (bACP) approaches, is used in aortic arch surgery to protect the brain during..

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Work in Europe: schools and Board

We are getting a lot of questions about working in Europe as a Perfusionist. Each country has its own regulations, its perfusion qualification, but we always say that a great..

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Mitochondrial Dysfunction in Cardiac Surgery

Abstract The human heart has one of highest metabolic requirements in the body: even in a resting physiologic state it must work to circulate approximately 5 L/min to 8 L/min..

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Activated Clotting Time Measured by Hemochron Signature Elite in Adult Cardiac Surgery: Implications for Clinical Practice

Abstract Objectives To assess concordance between Hemochron Response (ACTr) and the three-activator device Hemochron Signature Elite (ACTe) in adult cardiac surgery patients. To evaluate the correlation between ACTe and anti-Xa..

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Mortality and Complications in Hybrid Extracorporeal Membrane Oxygenation: A Meta-Analysis of Initial Use Versus Transition

Abstract Hybrid extracorporeal membrane oxygenation (ECMO), containing additional ECMO cannulations in addition to conventional ECMO, is increasingly used for the treatment of serious cardiopulmonary conditions. Patients initiating non-hybrid ECMO may..

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Pulsatile Physiological Control of Blood Pump-Cardiovascular System Based on Feedforward Compensation

Abstract Rotary Blood Pump (RBP) is a commonly used ventricular assist device. However, the constant speed operation of the blood pump leads to a reduction of blood flow pulsatility, which..

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Crisis management in the operating room: A systematic review of simulation training to develop non-technical skills

Abstract Aims Crises in the operating room, often resulting from human factors, endangers patient safety. Simulation-based training to develop non-technical skills shows promise in managing these crises. This review examines..

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Critical hematological parameters in bleeding during extracorporeal membrane oxygenation support

Abstract Bleeding complications are frequently observed in patients undergoing extracorporeal membrane oxygenation and are associated with increased mortality. Due to the complex mechanisms, managing bleeding during ECMO remains a challenge...

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Comprehensive secondary analysis of thrombotic events in pediatric patients receiving extracorporeal membrane oxygenation: A prospective cohort study

Abstract Introduction This study aims to describe laboratory and clinical factors associated with thrombotic events during prolonged pediatric extracorporeal membrane oxygenation. Methods A secondary analysis of a multi-center prospective study..

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Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiotoxic Drug-Induced Cardiogenic Shock: A Systematic Narrative Review

Abstract Background: Severe poisoning can lead to catastrophic cardiovascular collapse, often progressing to multiorgan failure and death. While intensive supportive care and pharmacological intervention remain the cornerstone of management, cases of..

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Transcutaneous Monitoring of Carbon Dioxide to Optimize Ventilator Weaning in At-Risk Adults After Cardiopulmonary Bypass

Abstract Background  Cardiopulmonary bypass use during surgery disrupts microcirculation, which can contribute to lung injury, particularly in patients with pulmonary comorbidities. Continuous transcutaneous carbon dioxide (CO2) monitoring assists clinicians to..

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