Abstract Background Veno-venous extracorporeal membrane oxygenation (VV ECMO) is a key therapy for refractory respiratory failure, but can trigger systemic inflammation and prothrombotic activation that impair the membrane lung (ML)...
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Abstract Background Severe glucose-6-phosphate dehydrogenase (G6PD) deficiency presents unique challenges during cardiopulmonary bypass (CPB) because of increased susceptibility to oxidative injury and haemolysis. Published guidance regarding optimal perfusion management remains..
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Abstract Background Refractory ventricular fibrillation/ventricular tachycardia (VF/VT) out-of-hospital cardiac arrest (OHCA) carries poor survival with conventional resuscitation. Extracorporeal cardiopulmonary resuscitation (ECPR) improves outcomes in selected patients; however, time to reperfusion..
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Abstract Cardiopulmonary bypass (CPB) during heart surgery provokes an inflammatory response that can cause post-operative organ injury, yet how CPB shapes key neutrophil effector programs is unclear. We investigated whether..
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Abstract Background: Hemolysis occurs frequently in patients requiring mechanical circulatory support (MCS) and is associated with worse outcomes. Carboxyhemoglobin (CO-Hb) has been suggested as a potential biomarker for detection of..
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Abstract Background Extracorporeal cardiopulmonary resuscitation (ECPR) is a time-critical intervention for selected patients with refractory cardiac arrest. Survival depends on minimizing low-flow duration before ECPR initiation. Timely deployment requires organizational..
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Abstract Background Norwood surgery is the first stage in the surgical palliation of hypoplastic left heart syndrome (HLHS) and its variants. Postcardiotomy extracorporeal membrane oxygenation (ECMO) may be required in..
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Abstract Objectives To determine whether carbon dioxide (CO2) field flooding during extracorporeal circulation (ECC) is associated with increased hourly sevoflurane consumption. Secondary objectives evaluated consumption differences between nonflooded procedures and..
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Abstract Background Brain development is altered in neonates with congenital heart disease (CHD), with well-characterised reductions in regional brain volumes and enlargement of CSF spaces. However, perioperative morphological changes remain..
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Abstract Aims Extracorporeal cardiopulmonary resuscitation (ECPR) may improve outcomes in selected patients with refractory out-of-hospital cardiac arrest (OHCA), but timely access is essential. In Greater London, a prehospital ECPR pathway..
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Abstract Background Extracorporeal life support (ECLS) is used as rescue therapy for refractory cardiopulmonary failure. Population-level evidence on prognosis and long-term sequelae in patients requiring ECLS during pregnancy or the..
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Abstract Introduction Palliative medicine (PM) aims to enhance the quality of life of patients and families facing serious illness. Currently, there are no national guidelines for involving PM in the..
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Abstract Background: Cerebral protection is a key determinant of perioperative outcomes in aortic arch surgery. Despite significant advances, optimal strategies regarding temperature, perfusion modality, and cannulation site remain controversial, with..
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Abstract Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has become an accepted treatment modality for refractory cardiogenic shock (CS). However, its use is limited to tertiary centers due to resource allocation, education,..
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Abstract Objectives The hemostatic system in neonates and infants with congenital heart disease is distinct as a result of developmental and disease-specific factors, necessitating population-specific periprocedural evaluation and antithrombotic management...
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Abstract Purpose To evaluate changes in post-operative transfusion requirements of infants undergoing congenital diaphragmatic hernia (CDH) repair on ECMO following implementation of a perioperative guideline. Methods In 2021, a multidisciplinary..
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Abstract Observational studies comparing Impella and venoarterial extracorporeal membrane oxygenation (VA-ECMO) in cardiogenic shock have reported inconsistent findings. We performed an updated systematic review and meta-analysis, with exploratory matched-cohort analyses..
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Abstract Objective To evaluate the effects of intravenous iron on red cell transfusion and recovery after cardiac surgery. Design International, multicentre, double blind, placebo controlled randomised trial (ITACS). Setting 33..
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Abstract Physiological anticoagulants are essential regulators of coagulation, and their deficiency shifts hemostasis toward a prothrombotic state, increasing the risk of venous thromboembolism. The main physiological anticoagulants, antithrombin (AT), protein..
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Abstract Introduction to the Problem Triage of patients referred with advanced heart failure (HF) continues to revive the classic question: can we conduct a randomized trial comparing heart transplantation with..
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Abstract Venoarterial extracorporeal membrane oxygenation (V-A ECMO) is a technique used to provide short-term circulatory and respiratory support in patients with refractory cardiogenic shock and cardiac arrest who do not..
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Abstract BACKGROUND: Acute kidney injury (AKI) is a common and severe complication after cardiac surgery with cardiopulmonary bypass (CPB). Experimental data suggest that increasing CPB flow beyond standard targets may..
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Abstract Low-flow extracorporeal carbon dioxide removal (ECCO2R) may be useful when severe hypercapnia limits ultra-protective ventilation but full venovenous extracorporeal membrane oxygenation (VV-ECMO) is not pursued. We describe a 68..
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Abstract Antimicrobial use in patients receiving extracorporeal membrane oxygenation (ECMO) is poorly described. In this study, evaluating antimicrobial use at a single center without ECMO-specific antimicrobial prophylaxis protocols, antimicrobials were..
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Abstract Introduction:Extracorporeal Membrane Oxygenation (ECMO) has evolved as an effective mechanical support for cardiorespiratory failure in patients undergoing congenital cardiac surgery, and the threshold of using it has substantially reduced...
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Abstract Objective Hemostatic therapy is commonly used in cardiac surgery. Despite tools to reduce inappropriate use, variability remains, mainly due to a lack of standards, especially intraoperatively. This study examined..
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Abstract Obesity is common among critically ill adults, but its association with outcomes during venovenous extracorporeal membrane oxygenation (VV ECMO) remains controversial. We evaluated associations of body mass index (BMI)..
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Abstract Objectives To develop and validate a scale to measure nursing activities in patients receiving extracorporeal membrane oxygenation (ECMO) and to examine its underlying factor structure. Methods A multicentre cross-sectional..
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Abstract Objectives To evaluate whether an activated clotting time (ACT)-guided, formula-based anticoagulation strategy supported by viscoelastic coagulation monitoring (ROTEM) improves perioperative coagulation management and reduces bleeding compared with standard weight-based..
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Abstract Background Extracorporeal membrane oxygenation, although lifesaving, is invasive. Complications affecting all body systems mandate reevaluation of goals of care. When extracorporeal membrane oxygenation is nonbeneficial, planning for de-escalation/decannulation to..
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