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Rescue Therapy With Factor VII for Refractory Cardiac Surgical Bleeding: A Propensity-Score-Matched Study

Abstract Objectives To compare effectiveness and safety of rescue therapy approach with recombinant Factor VII activated (rFVIIa) for refractory bleeding in cardiac surgery compared with a propensity-score-matched control group at..

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Baseline characteristics and in-hospital mortality predictors in female patients on venovenous extracorporeal membrane oxygenation: Impact of pregnancy

Abstract Background Venovenous extracorporeal membrane oxygenation (VV-ECMO) is often used for lung rest in critically ill patients, including pregnant patients. Objectives We aimed to determine how pregnant and non-pregnant patients..

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Predicting Successful Weaning from Veno-Arterial ECMO Using Machine Learning

Abstract Extracorporeal Membrane Oxygenation (ECMO) is a life-saving cardiopulmonary support for patients with acute heart failure. However, the process of weaning from veno-arterial (V-A) ECMO remains complex and risky. We..

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Simulation-Based Education for Extracorporeal Membrane Oxygenation and Strategies for Implementation

Abstract Simulation-based education (SBE) in health care is expanding in both scope and relevance. As on-the-job training is challenging in extracorporeal membrane oxygenation (ECMO), SBE features strongly in its curricula,..

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Machine learning in predicting preoperative intra-aortic balloon pump use in patients undergoing coronary artery bypass grafting

Abstract Background Intra-aortic balloon pump (IABP) implantation in the perioperative period of cardiac surgery is an auxiliary treatment for cardiogenic shock. However, there is a lack of effective prediction models..

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ELSO 2025 Narrative Guideline on the Use of ECMO for Accidental Hypothermia

Background Accidental hypothermia (AH) can be caused by exposure to cold weather conditions, immersion in water, avalanche burial in snow, or indoors, mostly affecting elderly patients with multiple comorbidities., There are..

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Clinical outcomes of levosimendan administration in veno-arterial extracorporeal membrane oxygenation: a meta-analysis

Abstract Objectives To evaluate the effectiveness of levosimendan in promoting weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with refractory cardiogenic shock through a meta-analysis of clinical trials. Design Systematic review..

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A randomised clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: five-year and ten-year follow-up for neurodevelopmental outcomes…

Abstract Objective:This study aimed to evaluate school-age neurodevelopmental outcomes among children with single ventricle heart disease who underwent neonatal Norwood operation with regional cerebral perfusion compared to deep hypothermic circulatory..

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Decreased renal or cerebral oxygen saturation increases the risk of cardiac surgery-associated acute kidney injury in adult patients: a prospective…

Abstract Objective To determine the relationship between intraoperative decreased renal and cerebral oxygen saturation, as measured using near-infrared spectroscopy (NIRS), and cardiac surgery-associated acute kidney injury (CSA-AKI) in adults. Methods..

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Outcomes of a Second Run of Extracorporeal Membrane Oxygenation in Neonates: A Propensity Score Matched Analysis of a Nationwide Registry

Abstract This study analyzed the outcomes of neonates undergoing a second run of extracorporeal membrane oxygenation (ECMO) to determine whether there is a benefit to a repeated run. We used..

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Selective Cytopheretic Device Therapy in the Context of Extracorporeal Membrane Oxygenation

Abstract This review examines the clinical data and basic science research to evaluate the potential of the Selective Cytopheretic Device (SCD) in mitigating Extracorporeal Membrane Oxygenation (ECMO)-associated inflammation. In brief,..

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Pre-bypass ultrafiltration reduces cytokine burden of blood prime in pediatric cardiac surgery

Abstract Allogeneic red blood cells (RBCs) are commonly used for cardiopulmonary bypass (CPB) circuit priming in congenital heart surgery. While convection-based pre-bypass ultrafiltration (PBUF) corrects acid–base, electrolyte, and metabolite imbalances,..

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Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologies

Abstract The COVID-19 pandemic has revealed that the impact of SARS-CoV-2 infection extends well beyond the acute phase, with long-term sequelae affecting multiple organ systems, most notably, the cardiovascular system...

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Less Is More for Bleeding Management Algorithms in Cardiac Surgery: A Network Meta-Analysis and Meta-Regression of Randomized Studies

Abstract BACKGROUND:  Major bleeding after cardiac surgery is still a relatively common complication, requiring red blood cell (RBC) transfusions and use of procoagulants. The existing guidelines recommend a bleeding management..

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Restrictive versus liberal oxygenation in patients undergoing cardiopulmonary bypass-assisted heart surgery: a randomised controlled trial

Abstract Background Maintaining adequate oxygen delivery during cardiopulmonary bypass (CPB)-assisted cardiac surgery is crucial, but hyperoxia has been suggested to cause organ injury. We compared the effects of restrictive vs liberal oxygenation..

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Radiomics-enhanced modelling approach for predicting the need for ECMO in ARDS patients: a retrospective cohort study

Abstract Decisions regarding veno-venous extracorporeal membrane oxygenation (vv-ECMO) in patients with acute respiratory distress syndrome (ARDS) are often based solely on clinical and physiological parameters, which may insufficiently reflect severity..

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The evolution of artificial red blood cells and recent advances in state-of-the-art oxygen carrier technologies: a narrative review

Abstract The demand for homologous blood transfusions has reached an unprecedented level, driven by a declining donor population and the ever-increasing need for blood products. While significant advancements have been..

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Prolonged Mechanical Ventilation Before Venovenous Extracorporeal Membrane Oxygenation and In-Hospital Mortality in Patients With Acute Respiratory Distress Syndrome

Abstract Objectives:  To evaluate the relationship between the duration of pre-extracorporeal membrane oxygenation (ECMO) mechanical ventilation and mortality in acute respiratory distress syndrome (ARDS) patients undergoing venovenous ECMO. Design:  Retrospective..

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Delivery of oxygen during cardiopulmonary bypass and associated clinical outcomes among adult cardiac surgery patients: A systematic review

Abstract Purpose Oxygen delivery (DO2) during cardiopulmonary bypass (CPB) is critical in preventing postoperative complications in adult cardiac surgery. This systematic review aimed to assess the relationship between intraoperative DO2 during..

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Gut Microbiota, Microbial Metabolites, and Inflammation in Cardiac Surgery: Implications for Clinical Outcomes—A Narrative Review

Abstract Cardiac surgery, particularly procedures involving cardiopulmonary bypass (CPB), is associated with a high risk of postoperative complications, including systemic inflammatory response syndrome (SIRS), postoperative atrial fibrillation (POAF), and infection...

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European Resuscitation Council Guidelines 2025

Abstract The 2025 European Resuscitation Council (ERC) Guidelines present the most up-to-date evidence-based guidelines for the practice of resuscitation across Europe. The ERC Guidelines 2025 are based on evidence produced..

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Robustness of Randomized Controlled Trials Evaluating Acute Normovolemic Hemodilution as a Blood Conservation Strategy in Cardiac Surgery

Abstract Objective To evaluate the robustness of randomized controlled trials (RCTs) investigating acute normovolemic hemodilution (ANH), a blood conservation strategy designed to reduce transfusion requirements, in cardiac surgery using the..

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Controlling intraoperative hyperglycemia in the cardiac surgical patient using the computerized electronic insulin dose calculator

Abstract Perioperative hyperglycemia is associated with increased morbidity and mortality. We report the findings of our quality improvement project on the use of an electronic insulin dosing calculator (EIC) to..

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Residual blood management after ECMO weaning: Reinfuse, salvage, or discard?

Abstract Extracorporeal membrane oxygenation (ECMO) supports patients with severe refractory cardiac or respiratory failure but managing residual circuit blood after weaning lacks consensus. After decannulation, the oxygenator and circuit retain..

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Towards Portable Leg Perfusion: Initial Prototype Testing of a Selective Leg Perfusion System

Abstract Introduction Limb loss after combat injury is a major factor for morbidity in combat casualties. Although tourniquets clearly save lives, they can result in prolonged ischemia in large scale..

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A Fick tool: connecting Fick’s law and principle in teaching pulmonary gas exchange

Abstract In humans, the transfer of respiratory gases between the atmosphere and living cells depends on their diffusion between lungs, blood, and cells, as well as their advective transport by..

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Cerebral oximetry in antegrade versus retrograde cerebral perfusion in aortic surgery

Abstract Background The optimal cerebral protection strategy during complex aortic surgery remains controversial, and various brain monitoring modalities are used to provide different information to improve cerebral protection. This study..

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Organ Donation after Extracorporeal Cardiopulmonary Resuscitation: Clinical and Ethical Perspectives

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) has evolved into a life-saving therapy for select cardiac arrest patients, yet a growing body of evidence suggests it also holds promise as a bridge..

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Infection risks in patients treated by continuous renal replacement therapy and extracorporeal membrane oxygenation

Abstract Purpose of review  This review addresses the growing concern over nosocomial infections in patients undergoing extracorporeal membrane oxygenation (ECMO) and/or continuous renal replacement therapy (CRRT). As the use of..

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Delirium after coronary artery bypass grafting with cardiopulmonary bypass surgery: The value of cerebral autoregulation

Abstract Introduction Postoperative delirium affects up to 60% of cardiac surgical patients. No reliable gold standard method exists for preventing delirium after cardiac surgery. An example of patient-personal monitoring is..

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