Abstract International guidelines for the nutrition management of critically ill adults do not sufficiently cover the unique challenges and considerations of patients receiving extracorporeal membrane oxygenation (ECMO). The aim of..
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Abstract Background: The estimated incidence of acute kidney injury requiring renal replacement therapy (RRT), mainly continuous RRT (CRRT), in patients necessitating extracorporeal membrane oxygenation (ECMO) is approximately 50%. Currently, two..
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Abstract Computational fluid dynamics (CFD) is increasingly important in biomedical engineering; however, its use in medical device design remains constrained by regulatory requirements for model validation and verification. To address..
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Abstract Despite the refinement in guidelines and improving outcomes, a subset of patients with septic shock fails to respond to treatment and progresses into refractory septic shock with an associated..
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Abstract BACKGROUNDS In patients with cardiac surgery under cardiopulmonary bypass (CPB), postoperative inflammation is a driver of adverse outcomes. Endotoxaemia is one of the factors thought to trigger this inflammatory..
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Abstract In losing Lucian Leape to heart failure last 30 June, at the age of 94 years, we lost a rare physician whose insights fundamentally changed how clinicians and the..
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Abstract Hydrogen has emerged as a therapeutic agent in inflammatory critical illnesses due to its potential to modulate inflammation and oxidative stress. However, its role in extracorporeal membrane oxygenation (ECMO),..
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Abstract Objectives Peripheral nerve injury (PNI) is a clinically significant but frequently under-recognized complication after cardiac surgery and catheterization, contributing to postoperative morbidity. While PNI has been well characterized in..
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Abstract Refractory ventricular arrhythmias and cardiac arrest in younger patients are rare, life-threatening events, particularly when standard resuscitation fails. Extracorporeal membrane oxygenation (ECMO) provides temporary circulatory support, enabling hemodynamic stabilization,..
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Abstract Extracorporeal membrane oxygenation (ECMO) represents an established modality of intraoperative circulatory and respiratory support during lung transplantation (LTx). Systemic anticoagulation with unfractionated heparin (UFH) remains essential to prevent circuit..
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Abstract Postoperative thrombocytopenia (TP) is a serious complication of cardiopulmonary bypass (CPB). An accurate prediction model is crucial for the early identification of high-risk patients. This study aimed to develop..
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Abstract Background Acute respiratory failure after cardiac surgery is an uncommon complication, affecting morbidity and mortality. In these patients, respiratory extracorporeal membrane oxygenation (ECMO) support may be beneficial, as it..
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Abstract Objectives To assess whether systematic perioperative correction of anemia and/or iron deficiency (ID) improves hemoglobin (Hb) levels and reduces transfusion requirements in elective cardiac surgery. Design Post hoc analysis..
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Abstract Introduction Extracorporeal cardiopulmonary resuscitation (ECPR) using veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a treatment option for refractory cardiac arrest patients, but it has mostly been restricted to hospitals with..
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Abstract Axillary and subclavian artery cannulation for veno-arterial extracorporeal membrane oxygenation (V-A ECMO) offers clinical advantages but introduces complex flow dynamics within the aortic arch. This study employed patient-specific computational..
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Abstract Damage-associated molecular patterns (DAMPs) are endogenous molecules released during cellular stress or injury that trigger sterile inflammation. In perioperative settings, common triggers include surgical trauma, ischemia–reperfusion injury, cardiopulmonary bypass,..
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Abstract Myocardial protection remains one of the most critical determinants of success in cardiac surgery, particularly during prolonged ischemic periods associated with cardiopulmonary bypass and aortic cross-clamping. The article Custodial-HTK..
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Abstract To examine the global epidemiology of extracorporeal membrane oxygenation discontinuation due to resource limitation (EDRL), assessing differences across geographic regions and between pre- and post-coronavirus disease 2019 (COVID-19) periods...
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Abstract Background Patients with severe trauma are at high risk of developing life-threatening complications, including acute respiratory failure and circulatory collapse. Extracorporeal membrane oxygenation (ECMO) offers critical support when conventional..
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Abstract Ultrasound has become indispensable in the management of patients supported with extracorporeal membrane oxygenation (ECMO), enabling rapid diagnosis, procedural guidance, physiologic monitoring, and informed decision-making across the entire ECMO..
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Abstract Objectives The Association of Cardiothoracic Anesthetists Perioperative Risk of Blood Transfusion (ACTA-PORT) score was originally developed to predict the need for transfusion in cardiac surgery patients. Given the inter-relationship..
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When stopping is just as important as starting: the challenge of extracorporeal membrane oxygenation
Abstract Extracorporeal life support (ECLS) is a high-risk, high-cost intervention that often entails prolonged ICU and hospital stays. Its rapid evolution raises crucial questions of appropriateness, proportionality, and value. Whereas..
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Abstract Objectives To explore how early mechanical reperfusion impacts outcomes in high-risk pulmonary embolism (PE) patients supported by veno-arterial extracorporeal membrane oxygenation (V-A ECMO). Methods This retrospective international study included..
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Abstract Background Severe acute respiratory distress syndrome (ARDS) complicated by necrotizing pneumonia and septic shock carries a mortality exceeding 80%. Lung transplantation is rarely pursued because persistent sepsis, uncertainty regarding..
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Abstract A recent series of near-misses in which patients scheduled for organ recovery exhibited unexpected signs of consciousness recognized only moments before initiation of surgery has triggered investigations by national bodies. In September 2024, a..
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Abstract Fluid overload is common after resuscitation in critically ill patients and is independently associated with unfavorable outcomes. Ultrafiltration (UF) during renal replacement therapy is a common strategy to reverse..
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Abstract Objectives: To identify factors associated with the development of death by neurologic criteria (DNC) in neonates treated with extracorporeal membrane oxygenation (ECMO). Design: Retrospective registry study. Setting: Data reported..
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Abstract Background Controversies exist in anticoagulation practices in extracorporeal membrane oxygenation (ECMO). It is uncertain whether the intensity of anticoagulation affects ECMO outcomes. Objectives To conduct a meta-analysis to determine..
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Abstract Objective: To describe those neonates with dextro-transposition of the great arteries (d-TGA) who undergo preoperative support with extracorporeal membrane oxygenation (ECMO) and to compare outcomes in those undergoing the..
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Abstract The number of potential pediatric heart transplant recipients continues to exceed the number of donors, and consequently the waitlist mortality remains significant. Despite this, around 40% of all donated..
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