A 44-year-old man was diagnosed with a giant pheochromocytoma in the right retroperitoneal cavity following treatment for heart failure. Subsequent to improvement in cardiac function, the patient underwent a laparotomy to excise the tumor. Due to its considerable size, partial cardiopulmonary bypass and blood purification therapy were initiated to stabilize hemodynamics during the surgical intervention. Herein, we present the utilization of partial cardiopulmonary bypass and blood purification in the resection of a giant pheochromocytoma in a patient with a history of heart failure, which proved beneficial in ensuring hemodynamic stability.