Until recently, the central venous pressure (CVP) was the preferred variable to guide fluid therapy [1]. The interest for CVP has declined in the last few years, mainly after the publication of the 2016 version of the surviving sepsis campaign (SSC) guidelines, which no longer recommend it to guide fluid management in septic patients [2]. Nevertheless, CVP is a pivotal hemodynamic variable [3], since it is a major determinant of both the global cardiac function–through the Frank–Starling mechanism–and the venous status as it is the downstream pressure for venous return and for organ perfusion. In this article, we underline how important it is to measure CVP to assess at best the hemodynamic status of patients with shock and thus select appropriate therapeutic options.