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del Nido cardioplegia in adult cardiac surgery - scopes and concerns

Abstract The convenience offered by a single-dose cardioplegia strategy is the avoidance of interruption of the flow of surgery and, more importantly, a significant reduction in the cross-clamp time. del..

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Challenges with heparin-based anticoagulation during cardiopulmonary bypass in children: Impact of low antithrombin activity

Abstract Background  is one of the main natural  inhibitors. It is potentiated by heparin, and may be a key component of heparin response, particularly in infants aged <1 year. We sought to..

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Are We Overdiagnosing Acute Kidney Injury in Pediatric Patients Following Cardiac Surgery?

Abstract Background: The use of two diagnostic criteria in the current literature has led to some degree of ambiguity in the precise diagnosis of acute kidney injury in pediatric patients..

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Outcome after aortic valve replacement in children: A systematic review and meta-analysis

Abstract Objective Despite an increasing interest in pediatric  repair,  in children may be unavoidable. The evidence on outcome after pediatric aortic valve replacement is limited and usually reported in small case series...

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Central extracorporeal membrane oxygenation for refractory pediatric septic shock

Abstract Objective: To demonstrate positive outcome, to achieve higher flow rates, and to reverse shock more quickly by implementing central extracorporeal membrane oxygenation (ECMO) in children with refractory septic shock. Children..

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Extracorporeal Membrane Oxygenation for Adults With Refractory Septic Shock

Abstract Because of a severe dysregulation of the host response to infection, septic shock may induce a profound imbalance between oxygen consumption and delivery, which in some cases may be..

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The Hemovent Oxygenator: A New Low-Resistance, High-Performance Oxygenator

Abstract Extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R) provide respiratory support aimed at gaining time to allow patient’s recovery from hypoxemic and/or hypercapnic respiratory failure, respectively. However, in..

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Successful Antithrombin Administration in Andexanet Alfa-Associated Heparin Resistance

Abstract Case Report A 72-year-old man with a tachycardiomyopathy, atrium flutter, and atrial fibrillation underwent an elective radiofrequency ablation procedure. In addition to 5 mg of apixaban twice daily, his..

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Observational study of thrombosis and bleeding in COVID-19 VV ECMO patients

Abstract Introduction: COVID-19 has been associated with increased risk of thrombosis, heparin resistance and coagulopathy in critically ill patients admitted to intensive care. We report the incidence of thrombotic and..

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Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery

Abstract Objective Aortic surgery often causes massive bleeding due to hypofibrinogenemia. Predicting hypofibrinogenemia is useful for developing a hemostasis strategy, including preparing for blood transfusion. We made a formula for..

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Mechanisms of oxidative stress and myocardial protection during open-heart surgery

Abstract We investigated MBL2 and MASP2 genotypes, serum MBL (mannose-binding lectin) levels and activities of its complexes with associated serine Cold heart protection via cardioplegia administration, limits the amount of oxygen demand. Systemic normothermia..

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Mannose-binding lectin (MBL) insufficiency protects against the development of systemic inflammatory response after pediatric cardiac surgery

Abstract We investigated MBL2 and MASP2 genotypes, serum MBL (mannose-binding lectin) levels and activities of its complexes with associated serine proteases (MASP-1, MASP -2), in relation to complications following cardiac surgery in 195 children...

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Effects of modified ultrafiltration and conventional ultrafiltration combination on perioperative clinical outcomes in pediatric cardiac surgery

Abstract Background: This meta-analysis was performed to review the effects of the addition of modified ultrafiltration (MUF) and conventional ultrafiltration (CUF) to CUF alone on postoperative hemoglobin, surgical and ultrafiltration..

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Modified ultrafiltration reduces postoperative blood loss and transfusions in adult cardiac surgery: a meta-analysis of randomized controlled trials

Abstract OBJECTIVES Cardiopulmonary bypass in cardiac surgery has been associated with several deleterious effects including haemodilution and systemic inflammation. Modified ultrafiltration (MUF) has been well established in paediatric cardiac surgery..

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An Adjusted Calculation Model Allows for Reduced Protamine Doses without Increasing Blood Loss in Cardiac Surgery

Abstract Background Heparin dosage for anticoagulation during cardiopulmonary bypass (CPB) is commonly calculated based on the patient's body weight. The protamine–heparin ratio used for heparin reversal varies widely among institutions..

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Association of Hospital-Level Volume of Extracorporeal Membrane Oxygenation Cases and Mortality. Analysis of the Extracorporeal Life Support Organization Registry

Abstract Rationale:  Recent pediatric studies suggest a survival benefit exists for higher-volume extracorporeal membrane oxygenation (ECMO) centers. Objectives:  To determine if higher annual ECMO patient volume is associated with lower..

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Use of CytoSorb in an infant with trisomy 21 and a complex heart defect, with septic shock and severe ARDS

This case reports on a 7-month-old male pediatric patient (known pre-existing conditions: trisomy 21 (also known as Downs syndrome), aortic isthmus stenosis, atrioventricular septal defect (AVSD) Rastelli type C), who..

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Use of CytoSorb in a pediatric patient with severe rhabdomyolysis in the context of a SARS-CoV-2 infection

This case reports on a 13-year-old male patient who presented to hospital with fever (38.9°), reduced general condition, vomiting and pain in his limbs.   [pdf-embedder url="https://perfusfind.com/wp-content/uploads/2021/02/Use-of-CytoSorb-in-a-pediatric-patient-with-severe-rhabdomyolysis-in-the-context-of-a-SARS-CoV-2-infection_compressed.pdf" title="Use of CytoSorb..

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Use of CytoSorb in a pediatric patient with septic shock in the setting of a non-controlled infectious focus

The case study reports on a 16-year-old girl, who presented to the hospital with syncope and fever (39°C), tachycardia, complaints of chest pain and coughing after fainting at home.  ..

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Use of CytoSorb in a pediatric patient with complex Shiga toxin induced thrombotic microangiopathy and severe multiple organ failure

This case reports on a 2-year-old male patient (weight 12 kg), who was admitted to the children‘s outpatient department with anuria, bloody diarrhea, anemia and severe edema (anasarca).   [pdf-embedder..

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Intraoperative extracorporeal cytokine adsorption in a case of cardiac transplant with congestive hepatitis post viral dilated cardiomyopathy

The following case study reports on a 13-year-old pediatric patient (body weight 45 kg) who was admitted to our hospital due to a deterioration in his clinical condition, after he..

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Neonatal and Pediatric General and Cardiac Anaesthesia and ICU: what’s new in 2017/2018 ? -Bari Pediatric Hospital Experience-Italy

Abstract This review wants to give an overview to most of the controversial fields in the clinical therapeutic assistance in neonatal and pediatric general and cardiothoracic surgery in anaesthesia and..

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Extracorporeal Life Support

Abstract This is a review of the University of Michigan experience with extracorporeal life support (ECLS) also known as extracorporeal membrane oxygenation (ECMO). Two thousand patients were managed with ECMO..

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The Efficacy, Safety and Cost-Effectiveness of Intra-Operative Cell Salvage in High-Bleeding-Risk Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Randomized and…

Abstract Objective: Intra-operative cell salvage (CS) was reported to be ineffective, safe and not cost-effective in low-bleeding-risk cardiac surgery with cardiopulmonary bypass (CPB), but studies in high-bleeding-risk cardiac surgery are limited...

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Post-Operative Bleeding Risk Stratification in Cardiac Pulmonary Bypass Patients Using Artificial Neural Network

Abstract The prediction of bleeding risk in cardiopulmonary bypass (CPB) patients plays a vital role in their postoperative management. Therefore, an artificial neural network (ANN) to analyze intra-operative laboratory data..

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Hemolytic characteristics of three suctioning systems for use with a newly developed cardiopulmonary bypass system

Abstract Introduction: We have been developing a closed-circuit cardiopulmonary bypass (CPB) system (“Dihead CPB”) for application during coronary artery bypass grafting (CABG) and valve surgery. To strive for minimal hemolysis..

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Establishing an ECMO program in a developing country: challenges and lessons learned

Abstract Aim: The ECMO (extracorporeal membrane oxygenation) Program at the American University of Beirut Medical Center was established in November 2015 as the first program serving adult and pediatric population..

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Developments in Pediatric Ventricular Assist Device Support

Abstract Mechanical support devices have revolutionized the management of circulatory failure. This has been met by a dramatic increase in ventricular assist device (VAD) utilization in children over the last..

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Aprotinin versus tranexamic acid in children undergoing cardiac surgery: an observational study

Abstract OBJECTIVES: The upcoming release of aprotinin in paediatric cardiac surgery prompted a re-evaluation of its use in comparison to tranexamic acid (TXA) focusing on their effect on exposure to..

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Hemolytic characteristics of three suctioning systems for use with a newly developed cardiopulmonary bypass system

Abstract Introduction: We have been developing a closed-circuit cardiopulmonary bypass (CPB) system (“Dihead CPB”) for application during coronary artery bypass grafting (CABG) and valve surgery. To strive for minimal hemolysis..

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