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Integrated or Parallel Configurations for Renal Replacement Therapy in Patients on VenoArterial Extracorporeal Membrane Oxygenation, a Single Center Retrospective Study

Abstract Background Acute kidney injury (AKI) is frequent in patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO), largely due to the severity of cardiogenic shock and multiorgan failure. Renal replacement..

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Epidemiology and outcomes of nosocomial infections in patients undergoing extracorporeal membrane oxygenation support: an eight-year retrospective cohort study

Abstract Background Patients supported with extracorporeal membrane oxygenation (ECMO) are susceptible to healthcare-associated infections (HAIs), which may worsen outcomes. However, epidemiological data from Latin American centres remain scarce. Methods We..

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Machine learning based retrospective cohort study to predict mortality risk in Chinese patients undergoing extracorporeal membrane oxygenation

Abstract Although extracorporeal membrane oxygenation (ECMO) has emerged as a pivotal temporary extracorporeal life support in critically ill patients, it is associated with a high risk of mortality. Establishing a..

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The Design of Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease Extracorporeal Membrane Oxygenation Study

Abstract Acute kidney injury (AKI) and fluid accumulation (FA) are common during extracorporeal membrane oxygenation (ECMO) support and are associated with increased morbidity and mortality. Despite their clinical importance, contemporary..

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Association between platelet indices and next-day bleeding and clotting in children and adults on extracorporeal membrane oxygenation: A retrospective study

Abstract Introduction Bleeding and clotting phenotypes are common in patients supported with Extracorporeal Membrane Oxygenation (ECMO) and are associated with increased mortality. However, tools to distinguish bleeding from clotting phenotypes..

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Cumulative exposure to factor XIII deficiency during veno-arterial extracorporeal membrane oxygenation: a prospective cohort study

Abstract Factor XIII (FXIII) contributes to clot stability and reduces clot susceptibility to lysis through fibrin cross-linking. Standard coagulation tests like prothrombin time and activated partial thromboplastin time do not..

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Decompensated Differential Carbon Dioxide Removal During Venoarterial Extracorporeal Membrane Oxygenation: A Physiologic Framework

Abstract Decompensated differential carbon dioxide (CO2) removal can occur during spontaneous breathing on peripheral venoarterial extracorporeal membrane oxygenation (V-A ECMO) when a low right radial arterial partial pressure of carbon..

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Enhancing early detection of acute brain injury using heart rate variability in patients on venoarterial extracorporeal membrane oxygenation

Abstract Introduction Early detection of acute brain injury (ABI) in patients on venoarterial extracorporeal membrane oxygenation (VA ECMO) is challenging. We aimed to investigate if heart rate variability (HRV) in..

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Improving bleeding and thrombosis in patients with extracorporeal life support: could hematology help?

Abstract Despite the advances in technology, new patient populations, new medications, and multiple monitoring algorithms for anticoagulation, bleeding, and thrombosis complications remain high among those receiving extracorporeal life support (ECLS)..

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Monitoring Hemostatic Function During Extracorporeal Membrane Oxygenation with Point-of-Care Viscoelastic Assays: A Narrative Review

Abstract Extracorporeal membrane oxygenation (ECMO) has increasingly been used in patients with refractory severe cardiorespiratory failure in recent years. The use of ECMO necessitates anticoagulation as blood passes through an..

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Percutaneous Versus Surgical Cannulation for Veno-Arterial Extracorporeal Life Support: A Systematic Review and Meta-Analysis

Abstract Background and Aims Extracorporeal life support (ECLS) is a critical intervention in the management of severe cardiac and respiratory failure. Among the commonly used cannulation techniques, percutaneous cannulation (PC)..

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Extracorporeal life support in adult critically ill patients: mechanisms of benefit in respiratory and cardiac failure

Abstract Extracorporeal life support provides temporary cardiorespiratory support for patients with severe, potentially reversible cardiac and/or respiratory failure refractory to conventional measures. Its application has broadened across a wide spectrum..

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The roles and responsibilities of an advanced practice nursing team for coordinating extracorporeal life support in intensive care: A qualitative…

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) is a type of mechanical circulatory support that is increasingly utilised for severe cardiorespiratory failure in the intensive care unit (ICU) setting. ECMO is..

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Use of extracorporeal membrane oxygenation with a cardiotomy reservoir for patient blood management in thoracoabdominal open surgery: A single centre…

Abstract Open thoracoabdominal aortic aneurysm repair (TAAAR) is associated with mortality rates of between 8% and 25%. One of the characteristics of TAAAR is massive bleeding that requires multiple units..

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Sweep Flow Nitric Oxide Effects on Coagulation, Inflammation, and Endothelial System Activation During Extracorporeal Membrane Oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a)..

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Short-Term Outcomes of Intra-Aortic Balloon Pump vs. Microaxial Flow Pump for Fulminant Myocarditis Supported by Venoarterial Extracorporeal Membrane Oxygenation

Abstract Background: The clinical differences between intra-aortic balloon pumping (IABP) and a microaxial flow pump (Impella) for left ventricular (LV) unloading in patients with fulminant myocarditis (FM) supported with venoarterial extracorporeal..

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Lactic alkalosis in a patient on veno-venous extracorporeal membrane oxygenation: A case report

Abstract Background: Lactic alkalosis, defined as an increase in circulating lactate in the setting of elevated extracellular pH, has been described in both in vivo and in vitro settings, often..

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Novel Use of a Distal Perfusion Catheter With a Removable Side Port in Patients on VA-ECMO

Abstract Risk of limb ischemia in patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) is minimized with the use of distal perfusion catheters (DPCs). However, conventional sheaths utilize a flow-limiting side..

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Guiding complexity in V-A ECMO weaning decisions for cardiogenic shock: Insights from a conjoint analysis

Abstract Weaning and liberation from V-A ECMO for cardiogenic shock involves complex decision-making that requires balancing multiple clinical parameters. In the absence of specific weaning guidelines, ECMO centers rely on..

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Heparin Exposure Adjustment to Reduce Thrombo-hemorrhagic Complications After Venoarterial Extracorporeal Membrane Oxygenator Cannulation: The HEART-ECMO Observational Cohort Study

Abstract Objectives Hemorrhagic complications remain a major concern in patients with cardiogenic shock and extracorporeal cardiopulmonary resuscitation. The purpose of this study was to assess the effect of withholding a..

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Clinical characterization of membrane oxygenator exhaust capnometry during venovenous extracorporeal membrane oxygenation

Abstract Capnometry is a cost-efficient method of monitoring carbon dioxide (CO2) in healthcare settings, especially during mechanical ventilation and cardiopulmonary bypass. However, the utility of capnometers for studying CO2 elimination in..

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Comparison of intermittent antegrade cardioplegia and antegrade/retrograde cardioplegia in cardiac surgery: A propensity-matched analysis

Abstract Background The aim of this study is to compare the clinical results of intermittent antegrade and intermittent antegrade/continuous retrograde cardioplegia techniques in patients undergoing cardiac surgery. Methods Between 2023..

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Outcomes and prediction of mortality in patients requiring prolonged veno-arterial extracorporeal membrane oxygenation support in the PRECISE-ECLS observational study

Abstract Background Veno-arterial ExtraCorporeal Membrane Oxygenation (V-A ECMO) as a bridge to recovery or long-term assist devices in severe cardiocirculatory failure typically lasts 5–7 days. There is scarce guidance on..

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Next-generation extracorporeal membrane oxygenation for multi-organ recovery after refractory cardiac arrest

Abstract Introduction: Survival after cardiac arrest and prolonged conventional cardiopulmonary resuscitation remains poor, with out-of-hospital survival rates of only 2%–10%. Conventional veno-arterial extracorporeal membrane oxygenation or extracorporeal cardiopulmonary resuscitation can restore..

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Exploring weaning-related shock: Cardiac injury and overload, platelet-endothelial cell activation, and inflammatory response markers following ECMO decannulation

Abstract Introduction Mortality in patients receiving Extracorporeal Membrane Oxygenation (ECMO) is partly attributable to unanticipated hemodynamic instability after elective decannulation, termed weaning-related shock (WRS). This study explored the etiology of..

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Subclavian or axillary artery cannulation for extracorporeal membrane oxygenation: A systematic review

Abstract Background Subclavian or axillary artery cannulation for venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides a valuable alternative to femoral access; however, a comprehensive overview of such an approach in this..

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Prevention and management of nosocomial infections in patients undergoing extracorporeal membrane oxygenation: a summary of best evidence

Abstract Purpose This study aimed to systematically search, evaluate, and synthesize the latest evidence on the prevention and management of nosocomial infections in patients supported by extracorporeal membrane oxygenation. Methods..

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Ventilator management on extracorporeal membrane oxygenation: considerations for open lung strategy

Abstract Purpose of review  The present review addresses the underlying biology of acute respiratory distress syndrome (ARDS) while recognizing that extracorporeal membrane oxygenation (ECMO) is an increasingly employed technology in..

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The invisible face of ECMO: anxiety levels and challenges among intensive care nurses

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a technology that provides temporary life support to critically ill patients with heart and/or lung failure. However, the complexity of the care involved..

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Distal Limb Perfusion in Extracorporeal Membrane Oxygenation

Abstract Limb ischemia is the most common vascular complication in patients receiving femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) and is associated with an increased risk of mortality., To improve blood flow..

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