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Best Evidence Summary of Brain Function Monitoring and Management in Patients Receiving Extracorporeal Membrane Oxygenation

Abstract Background Neurological complications are among the most serious adverse events in patients receiving extracorporeal membrane oxygenation (ECMO). Brain injury during ECMO is associated with increased mortality, long-term neurological deficits..

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Impact of side hole design of drainage cannulas on flow velocity and predilection sites for low-flow areas in veno-venous ECMO…

Abstract Background Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) (VV-ECMO) and Veno-Artial Extracorporeal Membrane Oxygenation (VA-ECMO) have become evidence-based therapy options for patients with most severe heart and/or lung failure. Cannulas continue..

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Monitoring Cerebral Perfusion during the Initiation of Veno-venous Extracorporeal Membrane Oxygenation

Abstract Support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be considered for patients with severe (combined) hypoxemia and hypercapnia. By adjusting sweep gas flow (SGF), blood oxygenation and correction of..

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Temporal trends in venoarterial extracorporeal membrane oxygenation and concurrent mechanical circulatory support for cardiogenic shock

Abstract Background Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is often combined with other temporary mechanical circulatory support (tMCS) in cardiogenic shock, yet combination-specific outcomes remain poorly defined. We compared temporal trends,..

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Use of extracorporeal membrane oxygenation (ECMO) in Spain as a method of organ preservation for transplantation

Abstract Donation following the confirmation of death based on circulatory criteria has proven to be a valuable strategy for increasing the availability of organs for transplantation. However, the standard super-rapid..

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The Role of Regret in Extracorporeal Membrane Oxygenation Candidacy Decision-Making

Abstract Background Veno-venous extracorporeal membrane oxygenation (VV ECMO) candidacy decisions are made under substantial uncertainty and are inconsistent. With a team including economist decision-scientists, we applied Regret Theory to hypothesize..

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Core components of transitional care for ECMO survivors after ICU discharge: a three-round modified Delphi study

Abstract Background Survivors of extracorporeal membrane oxygenation (ECMO) may experience persistent physical, cognitive, psychological, social, and quality-of-life impairments after intensive care unit (ICU) discharge. However, the core components of early..

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Extracorporeal Membrane Oxygenation Combined With Mechanical Thrombectomy Versus Extracorporeal Membrane Oxygenation Alone for High-Risk Pulmonary Embolism: A Systematic Review and…

Abstract Objectives To compare clinical outcomes of venoarterial (VA) extracorporeal membrane oxygenation (ECMO) combined with mechanical thrombectomy (MT) versus VA-ECMO alone in high-risk pulmonary embolism (PE). Design Systematic review and..

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Extracorporeal life support in adult critically ill patients: mechanisms of benefit in respiratory and cardiac failure

Abstract Extracorporeal life support provides temporary cardiorespiratory support for patients with severe, potentially reversible cardiac and/or respiratory failure refractory to conventional measures. Its application has broadened across a wide spectrum..

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Awake venoarterial extracorporeal membrane oxygenation as a bridge to foetal maturation in severe pulmonary hypertension: a case report

Abstract A 37-year-old patient (gravida 10, para 0–1–8-0) with class III obesity, obstructive sleep apnoea requiring continuous positive airway pressure and previous pulmonary emboli presented at 19 + 6 weeks' gestation with severe..

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Risk factors for in-hospital mortality in elderly patients receiving veno-venous extracorporeal membrane oxygenation: A single-center retrospective study

Abstract Background Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an established therapy for severe respiratory failure; however, few studies have examined the validity of and prognostic factors for VV-ECMO implementation in..

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Noninvasive Respiratory Support Before Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: A Meta-Analysis

Abstract The optimal timing for transitioning from noninvasive respiratory support to invasive mechanical ventilation and extracorporeal membrane oxygenation (ECMO) in severe acute respiratory distress syndrome (ARDS) remains controversial. PubMed and..

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Progress Toward a Portable Artificial Lung: A Systematic Review

Abstract Background Chronic respiratory diseases are the third leading global cause of death. As lung transplantation is a definitive treatment for highly selected candidates, extracorporeal membrane oxygenation (ECMO) can be..

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Road Map of Extracorporeal Membrane Oxygenation in the Early Post–Lung Transplant Period

Abstract Extracorporeal membrane oxygenation is increasingly used in the early postoperative period after lung transplantation, mainly to support patients with primary graft dysfunction and severe right ventricular failure. Recipients with..

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Acute Severe Asthma in the Intensive Care Unit: From Bronchodilators to Extracorporeal Membrane Oxygenation

Abstract Acute severe asthma exacerbations are life-threatening critical care emergencies characterized by profound airflow obstruction, respiratory acidosis, and risk for cardiopulmonary arrest. For the purposes of this review, the term..

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East-West Syndrome in Extracorporeal Membrane Oxygenation: Implications for Clinical Nursing Practice

Abstract As extracorporeal membrane oxygenation technology has evolved, interest in awake peripheral venoarterial extracorporeal membrane oxygenation has grown. This approach poses new challenges in patient monitoring. East-west syndrome is a..

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In Situ Venous Cannula Puncture: A Simplified Technique for Extracorporeal Membrane Oxygenation Blood Salvage

Abstract Salvaging residual circuit blood upon extracorporeal membrane oxygenation (ECMO) discontinuation is a clinically valuable blood conservation strategy, mirroring standard cardiopulmonary bypass protocols. We describe a simplified technique using an..

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Upper-Body Versus Femoral Return in Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-analysis

Abstract Upper-body peripheral arterial return is used during veno-arterial extracorporeal membrane oxygenation (VA-ECMO), but its clinical tradeoffs versus femoral return are uncertain. We reviewed observational studies comparing upper-body to femoral..

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Living-donor lung transplantation for patients on extracorporeal membrane oxygenation support: A case series

Abstract In Japan, the average waiting time for deceased-donor lung transplantation exceeds 900 days, and living-donor lung transplantation (LDLT) has been performed in a certain number of patients who are..

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Challenges in monitoring and titration of argatroban versus unfractionated heparin in extracorporeal membrane oxygenation

Abstract Objectives Anticoagulation during extracorporeal membrane oxygenation (ECMO) remains challenging. Direct thrombin inhibitors such as argatroban are increasingly proposed as alternatives to unfractionated heparin (UFH). We sought to characterize the..

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Extracorporeal membrane oxygenation liberation before heart transplantation in the modern allocation era: Predictors and one-year outcomes from the National OPTN/UNOS…

Abstract Background The clinical significance of ECMO liberation before heart transplantation remains poorly defined. Objectives To identify predictors of pre-transplant ECMO liberation and evaluate its association with 1-year post-transplant survival...

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Extracorporeal Membrane Oxygenation Combined With Embolectomy May Yield Better Outcomes Than Extracorporeal Membrane Oxygenation Alone or With Thrombolysis for Acute…

Abstract Veno-arterial extracorporeal membrane oxygenation (ECMO) is used to support patients with high-risk pulmonary embolism (HR-PE) with cardiogenic shock, but data on mid- and long-term outcomes after reperfusion remain limited...

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Membrane lung dead space and membrane lung impairment: An exploratory retrospective study in COVID-19 patients

Abstract Background Veno-venous extracorporeal membrane oxygenation (VV ECMO) is a key therapy for refractory respiratory failure, but can trigger systemic inflammation and prothrombotic activation that impair the membrane lung (ML)...

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The Minnesota Mobile Resuscitation Consortium ECMO truck: a feasibility study for ECPR in refractory out-of-hospital cardiac arrest

Abstract Background Refractory ventricular fibrillation/ventricular tachycardia (VF/VT) out-of-hospital cardiac arrest (OHCA) carries poor survival with conventional resuscitation. Extracorporeal cardiopulmonary resuscitation (ECPR) improves outcomes in selected patients; however, time to reperfusion..

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Assessing accessibility to the extracorporeal cardiopulmonary resuscitation pathway for out-of-hospital cardiac arrests in London

Abstract Aims Extracorporeal cardiopulmonary resuscitation (ECPR) may improve outcomes in selected patients with refractory out-of-hospital cardiac arrest (OHCA), but timely access is essential. In Greater London, a prehospital ECPR pathway..

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Pregnancy-associated extracorporeal life support: insights from a nationwide dual-cohort analysis

Abstract Background Extracorporeal life support (ECLS) is used as rescue therapy for refractory cardiopulmonary failure. Population-level evidence on prognosis and long-term sequelae in patients requiring ECLS during pregnancy or the..

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Not Just for the Dying: The Benefits of Routine Palliative Medicine Consultation in ECMO Care

Abstract Introduction Palliative medicine (PM) aims to enhance the quality of life of patients and families facing serious illness. Currently, there are no national guidelines for involving PM in the..

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A regional partnership model for VA-ECMO initiation and transfer from remote centers using air medical transport

Abstract Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has become an accepted treatment modality for refractory cardiogenic shock (CS). However, its use is limited to tertiary centers due to resource allocation, education,..

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Impella Versus VA-ECMO in Cardiogenic Shock: An Updated Systematic Review and Meta-Analysis With Exploratory Matched-Cohort Analyses

Abstract Observational studies comparing Impella and venoarterial extracorporeal membrane oxygenation (VA-ECMO) in cardiogenic shock have reported inconsistent findings. We performed an updated systematic review and meta-analysis, with exploratory matched-cohort analyses..

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Venoarterial ECMO management: Clinical considerations

Abstract Venoarterial extracorporeal membrane oxygenation (V-A ECMO) is a technique used to provide short-term circulatory and respiratory support in patients with refractory cardiogenic shock and cardiac arrest who do not..

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