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Delta-P as an early indicator of oxygenator failure: the case for standardized manufacturer reference values

Abstract The evolution of extracorporeal membrane oxygenation (ECMO) has led to an increasing reliance on objective parameters to detect complications early and enhance patient safety. One such parameter is the..

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Prognosis of Immunocompromised Patients With Respiratory Failure Managed With Venovenous Extracorporeal Membrane Oxygenation

Abstract Despite the increasing number of critically ill immunocompromised patients in intensive care unit, the outcome of different types of immunocompromised patients with respiratory failure managed with venovenous extracorporeal membrane..

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Beyond Standard Parameters: Precision Hemodynamic Monitoring in Patients on Veno-Arterial ECMO

Abstract Background: Hemodynamic management in veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is inherently complex, as extracorporeal circulation profoundly alters preload, afterload, ventriculo-arterial coupling and tissue perfusion. This review summarizes current..

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Time from mechanical ventilation initiation to venovenous extracorporeal membrane oxygenation in COVID-19: A prospective, multicentre, observational study

Abstract Background The impact of the duration of invasive mechanical ventilation (IMV) before venovenous extracorporeal membrane oxygenation (VV ECMO) on patient outcomes in COVID-19 remains unclear. Methods and setting Data..

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Levosimendan to Facilitate Weaning From ECMO in Patients With Severe Cardiogenic Shock

Abstract Importance  Levosimendan may facilitate weaning from venoarterial extracorporeal membrane oxygenation (VA-ECMO) and improve survival, but supporting evidence remains limited. Objective  To assess whether early administration of levosimendan reduces the time to..

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Extracorporeal Cardiopulmonary Resuscitation in Cardiac Arrest Associated to Neuroleptic Malignant Syndrome: A Case Report

Abstract Neuroleptic malignant syndrome (NMS) is a rare, life-threatening hypermetabolic reaction to dopamine-antagonist drugs that may progress to profound rhabdomyolysis, extreme hyperkalemia, and cardiac arrest (CA). Evidence guiding extracorporeal cardiopulmonary..

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Extracorporeal Membrane Oxygenation for Acute Respiratory Failure in a Dog

Abstract Extracorporeal membrane oxygenation (ECMO), a specialized medical technology that temporarily assumes the function of the heart and lungs, allows the body time to recover from severe respiratory failure. Although..

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Continuous EEG Monitoring and Clinical Outcomes in Patients Undergoing ECMO

Abstract Background Neurological complications during Extracorporeal membrane oxygenation (ECMO) can result in long-term cognitive deficits. This exploratory study aimed to determine the association between continuous EEG (cEEG) findings and neurological..

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Predictive Markers of Neurological Complications in Patients Treated With Extracorporeal Membrane Oxygenation

Abstract Critically ill patients rescued with extracorporeal membrane oxygenation (ECMO) are at risk for devastating complications, including stroke and intracerebral hemorrhage (ICH). Despite an appreciation of some clinical risk factors, we..

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Weaning from venovenous extracorporeal membrane oxygenation for acute respiratory failure: challenges and opportunities

Abstract Purpose of review  The process of weaning from venovenous extracorporeal membrane oxygenation (V-V ECMO) is a critical step in the recovery of patients with severe acute respiratory distress syndrome..

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Association between hyperoxia and mortality in patients undergoing extracorporeal membrane oxygenation: A systematic review and meta-analysis

Abstract Background The Association between hyperoxia and mortality in patients receiving extracorporeal membrane oxygenation (ECMO) remains controversial. This study aimed to systematically evaluate the impact of arterial hyperoxia on mortality..

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Percutaneous Versus Surgical Cannulation for Femoro-Femoral Venoarterial Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study on Cannulation-Related Complications

Abstract Background Cannulation for peripheral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) can lead to severe local complications. This study evaluated site-specific complications between percutaneous and surgical cannulation techniques for femoro-femoral..

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Predictive and prognostic factors for prolonged ECMO: a multicenter retrospective study

Abstract Purpose Prolonged ECMO has become more common during the COVID-19 pandemic but is associated with high resource utilization and poor outcomes. This study aimed to identify predictors of prolonged..

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Acute Kidney Injury After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest

Abstract OBJECTIVES:  Acute kidney injury (AKI) occurs frequently in ICUs and is associated with poor outcomes. However, little is known about AKI in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) for..

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Hydrogel nanocomposite-based breathable non-adhesive coating for oxygen sensing film used within extracorporeal perfusion system

Abstract Real-time, quantitative biosensing within extracorporeal perfusion (ECP) and extracorporeal membrane oxygenation (ECMO) systems is key to advancing this life-support technology beyond the hospital setting to emergency care. Measuring and..

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Kidney & extracorporeal support interactions: a narrative review

Abstract Purpose of review  Acute kidney injury (AKI) is common in critically ill patients, especially among those with severe and advanced organ failure. The use of extracorporeal support (ECS) is..

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Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy: a systematic review of the past decade (2014–2023)

Abstract Objective Extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) are often used together to treat critically ill patients. This systematic review aims to assess mortality and renal..

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The impact of arterial cannula direction in central venoarterial extracorporeal membrane oxygenation on aortic hemodynamic characteristics under various perfusion conditions

Abstract Objective To systematically evaluate the influence of cannula direction in central venoarterial extracorporeal membrane oxygenation (CVA ECMO) on aortic hemodynamics and oxygen transport through a multiparametric comparative analysis under..

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Veno-pulmonary extracorporeal membrane oxygenation for concomitant right ventricular and respiratory support: A systematic review of utilization patterns and outcomes

Abstract Background Veno-pulmonary artery extracorporeal membrane oxygenation (V-P ECMO) is a configuration of extracorporeal life support (ECLS) for patients with isolated or predominantly right ventricular (RV) failure and inadequate gas..

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Shear-induced dysregulation of haemostasis during extracorporeal membrane oxygenation: From cells to circuit

Abstract Extracorporeal membrane oxygenation (ECMO) is increasingly being utilized in critical care globally to allow for adequate oxygenation in patients with cardiac and/or respiratory failure. Unfortunately, haemostatic complications – both..

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Antithrombin Supplementation in Extracorporeal Membrane Oxygenation: A Systematic Review With Meta-Analysis

Abstract Background The Extracorporeal Life Support Organization recommends daily antithrombin monitoring and supplementation to achieve > 50%–80% activity during extracorporeal membrane oxygenation (ECMO). Evidence supporting this practice is uncertain, and whether..

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State-of-the-Art Update in Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest

Abstract ECPR Efficacy and Use: Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival and neurologic outcomes in refractory out-of-hospital cardiac arrest, with global adoption and center availability expanding significantly.

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Thresholds for Transfusion Practice During ECMO Support. A Systematic Review and Network Meta-Analysis

Abstract Purpose The benefits of adopting restrictive transfusion strategies, as opposed to a liberal approach, during extracorporeal membrane oxygenation (ECMO) remain unclear. This network meta-analysis aims to determine whether a..

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Evaluation of water loss during extracorporeal membrane oxygenation

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) can cause blood water loss due to insensible perspiration via oxygenators and plasma leakage. The accurate quantification of water loss is crucial for maintaining..

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Acute Brain Injury in COVID-19 Versus Influenza A Patients on Venovenous Extracorporeal Membrane Oxygenation: A Propensity Score Matching Analysis of…

Abstract Objectives:  Limited data exist on outcomes in COVID-19- vs. influenza A (H1N1)-associated acute respiratory distress syndrome (ARDS) patients when supported on venovenous extracorporeal membrane oxygenation (ECMO). We aimed to..

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A nitric oxide-releasing organic selenium-grafted phosphorylcholine coating for thrombosis and inflammation prevention in extracorporeal membrane oxygenation

Abstract Thrombosis and inflammation represent major challenges limiting the functionality of asymmetric poly(4-methyl-1-pentene) (PMP) hollow fiber membranes in extracorporeal membrane oxygenation (ECMO) systems. Moreover, the interplay between these two pathological..

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Acquired factor XIII deficiency in adult patients during ECMO: a prospective observational study

Abstract Data on factor XIII (FXIII) activity in patients on extracorporeal membrane oxygenation (ECMO) are scarce. In this prospective, observational, single-centre study, we determined the rate of acquired FXIII deficiency..

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Heart support crossroads: aortic Impella 5.5 implantation compared to conventional axillary approach in combined use of extracorporeal membrane oxygenation and…

Abstract Background: Postcardiotomy shock, often necessitates advanced mechanical circulatory support. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and the Impella 5.5 device are crucial for hemodynamic stabilization. This study evaluates the efficacy and..

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Extracorporeal membrane oxygenation in obstetrical patients: a meta-analysis

Abstract Critically acute and ill and Obstetrical patients constitute a unique clinical population with a high mortality rate. Extracorporeal membrane oxygenation (ECMO) is gradually being used in obstetrical acute and..

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Renal Angina Index as a Predictor of Renal Injury Progression in Patients on Extracorporeal Membrane Oxygenation Support: The DREAMS Study

Abstract This retrospective cohort study evaluates the validity of the Renal Angina Index (RAI) in predicting acute kidney injury (AKI) in 272 patients receiving extracorporeal membrane oxygenation (ECMO) support. The..

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