Abstract Objective: To compare the effects of intermittent classical blood cardioplegia and single-dose modified Del Nido cardioplegia on postoperative serum lactate levels and extubation time in patients undergoing coronary artery bypass..
Read MoreAbstract Background Acute aortic dissection of the ascending aorta is a life-threatening disease that poses a significant challenge for cardiovascular surgeons. Dissection of the aorta typically occurs when the aortic..
Read MoreAbstract Objectives To test the hypotheses that intraoperative hyperlactatemia is independently associated with increased postoperative infection risk in cardiac surgery with cardiopulmonary bypass (CPB). Methods This study involved 4970 cardiac..
Read MoreAbstract Objectives To evaluate the efficacy of intraoperative hemoadsorption (HA) during cardiopulmonary bypass (CPB) in reducing acute kidney injury (AKI) and other major postoperative complications in patients undergoing cardiac surgery...
Read MoreAbstract Purpose Cardiopulmonary bypass (CPB) is a well-established procedure that uses cannulae during cardiac surgery to drain and return blood. In challenging cases (e.g. aortic dissection, reoperation), peripheral cannulation in..
Read MoreAbstract Background Heparin is commonly administered to prevent thrombosis during cardiopulmonary bypass (CPB). However, the development of intracardiac thrombi under CPB has still been reported. Case summary A 79-year-old man..
Read MoreAbstract Malignant hyperthermia (MH) is a rare but potentially fatal disorder characterized by a hypermetabolic state produced by exposure to triggering agents such as volatile anesthetics and succinylcholine., MH crises have..
Read MoreAbstract Background Advances in medicine lead to an increase in the number of patients with concurrent heart disease and cancer. We investigated the effect of cardiac surgery under cardiopulmonary bypass..
Read MoreAbstract Objectives This study hypothesizes that induced hypothermia (IH) can safely extend aortic cross-clamp (ACC) time, significantly reducing metabolic burden and end-organ injury, thereby enabling more comprehensive aortic arch reconstructions..
Read MoreAbstract Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs...
Read MoreAbstract Objectives Cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) or life support (ECLS) circuits are built from polymers and might release polymeric micro- and nanoparticles (MNP) into the circulation...
Read MoreAbstract Background During cardiac surgery the use of a minimal extracorporeal circulation (MiECC) system may reduce the adverse effects for the patient. This is probably caused by reduced inflammation and..
Read MoreAbstract BACKGROUND The choice of priming and volume replacement fluids during cardiopulmonary bypass (CPB) in cardiac surgery impacts hemodynamic stability, coagulation, renal function, and patient outcomes. Hydroxyethyl starch (HES) 130/0.4..
Read MoreAbstract Objectives The central cannulation technique was introduced at our institution in 2018 and has evolved into a primary cannulation strategy for acute type A aortic dissection (ATAAD) surgery. This..
Read MoreAbstract Background The membrane oxygenator is a critical component of extracorporeal circulation (ECC), whose performance directly depends on its structural architecture. Differences in fiber geometry and winding patterns lead to..
Read MoreAbstract To the Editor: I wish to share the results of a retrospective observational correlation study I completed recently. While it is well established that the platelet count is negatively..
Read MoreAbstract Background: Delirium after cardiac surgery is associated with poor outcomes. Cardiopulmonary bypass (CPB) increases blood-brain barrier (BBB) permeability and neuroinflammation, contributing to delirium. While microglial activation after CPB has..
Read MoreAbstract Vasoplegic syndrome is a life-threatening condition characterized by uncontrolled peripheral vasodilation, leading to profound arterial hypotension. Treatments include catecholamines, vasopressin, methylene blue (MB), hydroxocobalamin, angiotensin II, and ascorbic acid...
Read MoreAbstract BACKGROUNDS In patients with cardiac surgery under cardiopulmonary bypass (CPB), postoperative inflammation is a driver of adverse outcomes. Endotoxaemia is one of the factors thought to trigger this inflammatory..
Read MoreAbstract Objectives Cardiac surgery is associated with an increased dioxygen (O2) consumption (VO2) following cardiopulmonary bypass (CPB). But data on intraoperative VO2 variation during pulmonary endarterectomy (PEA) are scarce. We aimed..
Read MoreAbstract Objective: We herein probed the effects of ozone autohemotherapy (O3-AHT) on inflammatory response and postoperative cognitive function in patients undergoing valve replacement with cardiopulmonary bypass (CPB). Methods: Totally, 130..
Read MoreAbstract Background Cardioplegia is delivered via antegrade, retrograde, or combined perfusion routes. Antegrade cardioplegia follows the physiological path but may be less effective in patients with severe coronary disease. Retrograde..
Read MoreAbstract Heparin is the primary anticoagulant used for cardiopulmonary bypass and requires reversal to prevent postoperative bleeding. Protamine sulfate is the only United States Food and Drug Administration–approved heparin reversal..
Read MoreAbstract Purpose To assess the effects of conventional ultrafiltration and conventional plus zero-balanced ultrafiltration on delirium and cognition in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Methods A total..
Read MoreAbstract Background: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and cardiopulmonary bypass (CPB) are used during pediatric heart surgery to provide cardiopulmonary support to patients as they undergo and recover from surgical..
Read MoreAbstract OBJECTIVES: Vasoplegia is a common complication of cardiac surgery that uses cardiopulmonary bypass and contributes to morbidity and mortality, yet a consensus definition does not exist. The objective of..
Read MoreAbstract Purpose: Cryoprecipitate has been covered by Japanese national health insurance since 2020 for cardiopulmonary bypass (CPB)-induced hypofibrinogenemia. This study evaluated the clinical efficacy of in-house cryoprecipitate use in patients..
Read MoreAbstract Background/Objectives: Whether a remote history of SARS-CoV-2 infection independently affects early haemodynamic stability after elective cardiopulmonary bypass (CPB) remains uncertain. We evaluated whether prior COVID-19 (>7 weeks before surgery)..
Read MoreAbstract Background Elevated central venous pressure during cardiac surgery can lead to increased renal venous pressure, subsequently resulting in renal insufficiency. However, there is a lack of animal models available..
Read MoreAbstract Separation from cardiopulmonary bypass (CPB) is a critical phase of cardiac surgery, particularly in patients with pulmonary hypertension and right heart failure. Milrinone, a phosphodiesterase inhibitor, is often used..
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