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Propofol-supplemented cardioplegia: A multicenter blinded 3-group randomized trial (Propofol for Myocardial Protection Trial 2: ProMPT2)

Abstract Objective: Coronary artery bypass grafting using cardiopulmonary bypass and cardioplegic arrest is an effective treatment for coronary artery disease. Research suggests supplementing the cardioplegia solution with propofol may be..

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Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan

Abstract Background Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective..

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Cerebral Hemodynamic Changes and Postoperative Brain Function in Patients Undergoing Cardiac Valve Surgery With Cardiopulmonary Bypass: A Prospective Cohort Study

Abstract Background Cardiopulmonary bypass (CPB) during cardiac surgery disrupts cerebral hemodynamics, potentially leading to postoperative neurological complications such as delirium. Transcranial Doppler (TCD) offers non-invasive monitoring of cerebral blood flow..

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Comparison of post-operative inflammatory biomarkers between minimal invasive extracorporeal circulation and conventional extracorporeal circulation in cardiac surgery. A meta-analysis of…

Abstract Background/Aim Recent literature suggested that the use of Minimal Invasive Extracorporeal Circulation (MIECC) may mitigate the inflammatory response in patients undergoing cardiac surgery. We aimed to perform a meta-analysis..

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Impact of changes in cardiopulmonary bypass circuit design on pressure loss, wall shear stress, and venous drainage flow

Abstract Introduction Blood damage during cardiopulmonary bypass can trigger postoperative inflammatory responses and organ injury. Therefore, optimizing the blood circuit design to minimize damage remains essential. However, variations in venous..

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Between Air and Artery: A History of Cardiopulmonary Bypass and the Rise of Modern Cardiac Surgery

Abstract Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs...

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Inadequate Oxygen Delivery During Cardiopulmonary Bypass Drives Inflammatory Reaction after Cardiac Surgery

Abstract Objectives Systemic inflammatory response syndrome (SIRS) is a common complication following cardiopulmonary bypass (CPB), associated with increased mortality. We assessed the relationship between indexed oxygen delivery (DO2i) during CPB..

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Impact of Low Hematocrit on On-Pump Coronary Artery Bypass Graft Surgery Outcomes

Abstract Background: Low hematocrit level is a hematological problem that is frequently encountered during cardiopulmonary bypass (CPB) in patients undergoing on-pump coronary artery bypass grafting (CABG). This study aimed to..

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Monitoring Oxygen Delivery During Cardiopulmonary Bypass: A Preliminary Multinational Practice Survey

Abstract Objectives Oxygen delivery (DO2) is a pivotal factor in maintaining adequate tissue protection during cardiopulmonary bypass (CPB). Despite its clinical significance, there is currently no global consensus regarding standardized..

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Effect of Ciprofol on Postoperative Cognitive Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial

Abstract Purpose: To investigate the effects of ciprofol on postoperative cognitive function in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Patients and Methods: A total of 138 patients who underwent cardiac..

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Inadequate Oxygen Delivery During Cardiopulmonary Bypass Drives Inflammatory Reaction after Cardiac Surgery

Abstract Objectives Systemic inflammatory response syndrome (SIRS) is a common complication following cardiopulmonary bypass (CPB), associated with increased mortality. We assessed the relationship between indexed oxygen delivery (DO2i) during CPB..

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Delivery of oxygen during cardiopulmonary bypass and associated clinical outcomes among adult cardiac surgery patients: A systematic review

Abstract Purpose Oxygen delivery (DO2) during cardiopulmonary bypass (CPB) is critical in preventing postoperative complications in adult cardiac surgery. This systematic review aimed to assess the relationship between intraoperative DO2 during..

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Management of Emergency Cardiopulmonary Bypass Failure During Robot-Assisted Mitral Valve Repair: Successful Recovery With Hypothermia and Centrifugal Pump Exchange

Abstract CARDIOPULMONARY BYPASS (CPB) is an essential component of cardiac surgery, and its unexpected failure during surgery can compromise circulatory and respiratory management, potentially endangering the patient's life. In the..

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The effect of administration of Del Nido cardioplegia solution containing vitamin C on myocardial protection and clinical outcomes in patients…

Abstract Background A main concern during cardiac surgery is the protection of the heart. Myocardial ischemia tends to increase the generation of reactive oxygen species. Based on its oxidation–reduction potentials,..

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Acute Normovolemic Hemodilution in Adult Cardiac Surgery

Abstract Importance  Acute normovolemic hemodilution (ANH) is a well-known blood conservation technique, yet its adoption in the US remains low (<20%), and cardiac surgery remains the largest consumer of blood components...

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Mean arterial pressure difference before and during cardiopulmonary bypass: what should be the ideal mean perfusion pressure?

Abstract Objectives: The difference between mean arterial pressure (MAP) before cardiopulmonary bypass (CPB) and mean perfusion pressure (MPP) during CPB is thought to be a strong predictor of acute kidney injury..

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Targeting the contributors to vasorelaxation during vasoplegia from cardiopulmonary bypass

Abstract Vasoplegia, a syndrome of noncardiogenic, non-hypovolaemic vasodilatory hypotension is a common complication of cardiac surgery utilising cardiopulmonary bypass. Vasopressor-sparing strategies have been increasingly used in the management of vasoplegia..

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Unsupervised machine learning to explore inflammation following cardiopulmonary bypass

Abstract Introduction Cardiac surgery with cardiopulmonary bypass (CPB) often induces systemic inflammatory reaction syndrome (SIRS), affecting postoperative outcome. We aimed to explore adaptive/maladaptive inflammation using unsupervised machine learning. Methods We..

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The dynamic interplay between endothelial reactivity, temperature, and vascular resistance in cardiopulmonary bypass

Abstract Cardiopulmonary bypass serves as a cornerstone in cardiac surgery, enabling life-sustaining circulatory and respiratory support during complex procedures that necessitate the temporary cessation of cardiac activity. This intricate process..

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The role of acute normovolemic hemodilution and retrograde autologous priming in reducing intraoperative packed red blood cell transfusion needs in…

Abstract Background Acute normovolemic hemodilution (ANH) and retrograde autologous priming (RAP) are blood conservation techniques designed to reduce transfusion requirements. Purpose This study evaluated the impact of combining ANH and..

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An intraoperative nightmare: sudden bilateral lower limb malperfusion during type A acute aortic dissection surgery

Abstract Lower limb malperfusion for type A acute aortic dissection (ATAAD) is a challenging complication, particularly when it occurs suddenly during the operation. We report a 76‐year‐old female with ATAAD..

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Selective visceral perfusion in thoracoabdominal aortic surgery: optimal flow rate in a porcine model

Abstract To determine the optimal perfusion volume for the celiac artery (CA) and superior mesenteric artery (SMA) in a porcine model. Fifteen Yorkshire pigs (46.7 ± 5.2 kg) underwent selective CA and..

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Malperfusion, Malperfusion Syndrome, and Mesenteric Ischemia in Aortic Dissection

Abstract Aortic malperfusion occurs in a significant percentage of patients with acute , and causes , the clinical entity defined by end organ , in 10–33% of patients. Malperfusion syndrome can be rapidly..

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Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem

Abstract Activation of the alternative complement pathway by artificial extracorporeal surfaces is relevant to several clinical applications such as cardiac surgery with cardiopulmonary bypass (CPB), thoracic organ transplantation and hemodialysis...

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Modified cardiopulmonary bypass circuit for transcatheter aortic valve implantation and emergent cardiac surgery

Abstract Transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of severe aortic stenosis in high-risk patients, offering a minimally invasive alternative to open-heart surgery. However, complications such as hemodynamic..

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Fluid management of cardiopulmonary bypass during pulmonary endarterectomy for CTEPH patients impacts perioperative outcome

Abstract Background Pulmonary endarterectomy (PEA) using deep hypothermic circulatory arrest (DHCA) and cardiopulmonary bypass (CPB) is the preferred treatment for chronic thromboembolic pulmonary hypertension (CTEPH). Crystalloid priming solutions cause hemodilution..

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The progress and trends of the mechanism of cardiopulmonary bypass-associated acute lung injury: A narrative review

Abstract Studies into the mechanisms of cardiopulmonary bypass-associated acute lung injury have not presented breakthroughs for many years, resulting in the stagnation of management strategies and clinical medicine measures. This..

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The organ-protective effects of nitric oxide in adult patients undergoing cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis

Abstract Postoperative organ dysfunction remains a major challenge in adult cardiac surgery with cardiopulmonary bypass (CPB), frequently involving the kidneys, heart, and lungs. These complications are primarily driven by hemolysis,..

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Network meta-analysis of cardioplegic methods, in elective isolated coronary artery bypass grafting

Abstract Background Cardioplegic arrest can be induced by various methods, fueling a long-standing controversy about their comparative merit. We aim to compare cardioplegic methods in coronary artery disease. Methods PubMed,..

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Perspectives on the Predictive Role of PvCO2 × Ve/Q for Hyperlactatemia During Cardiopulmonary Bypass

Abstract We read with great interest the article by Kowara et al.,[] which highlights the potential of PvCO2 × Ve/Q as a key predictive marker for hyperlactatemia during cardiopulmonary bypass (CPB). This..

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