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Objective Content Validation of the Hemodynamic and Technical Parameters of the Orpheus TM Cardiopulmonary Bypass Simulator

Abstract The utilization of simulators for training is increasing in the professions associated with cardiac surgery. Before applying these simulators to high-stakes assessment, the simulator's output data must be validated...

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Central Partial Bypass Management Technique for Distal Arch Surgery

Abstract Circulatory arrest and left heart bypass are the most common approaches to manage perfusion during distal arch surgery. We report a novel perfusion technique utilized in the treatment of..

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Kinetics of tissue oxygenation index during fast and slow cardiopulmonary bypass initiation

Abstract Introduction Despite being a daily clinical application in cardiac operating theaters, an evidence-based approach on how to optimally initiate the heart–lung machine (HLM) to prevent critical phases of cerebral..

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The Fundamental Skills and Deconstructed Sub-Steps of Pediatric Cardiopulmonary Bypass

Abstract Perfusion education programs use simulation to provide students with clinical skills prior to entering the operating room. To teach the psychomotor execution of skills in a simulation lab requires..

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A Pharmacokinetic and Plasmin-Generation Pharmacodynamic Assessment of a Tranexamic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass

Abstract Objectives To examine the  (PK) and  of a tranexamic (TXA) regimen designed for cardiac surgery with  (CPB). Design A pilot study quantifying TXA concentrations,  markers, and a plasmin- generation (PG) assay. For comparison,..

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Effect of CPB Glucose Levels on Inflammatory Response After Pediatric Cardiac Surgery

Abstract Background: Systemic inflammatory response syndrome (SIRS) is a common complication after cardiac surgery. There are no definite optimal glycemic threshold for pediatric patients receiving open-heart surgery with CPB. The..

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Retrograde Autologous Priming as a Safe and Easy Method to Reduce Hemodilution and Transfusion Requirements during Cardiac Surgery

Abstract Background: During the last decades many efforts have been made to reduce transfusion requirements and adverse clinical effects during cardiopulmonary bypass (CPB). The minimal extracorporeal circulation (MECC) system and the..

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To RAP or Not to RAP: A Retrospective Comparison of the Effects of Retrograde Autologous Priming

Abstract Retrograde autologous priming (RAP) is a process used to reduce hemodilution associated with the initiation of cardiopulmonary bypass (CPB). Previous studies have reported potential benefits to RAP; however, many..

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Renal and Cerebral Hypoxia and Inflammation During Cardiopulmonary Bypass

Abstract Cardiac surgery-associated acute kidney injury and brain injury remain common despite ongoing efforts to improve both the equipment and procedures deployed during cardiopulmonary bypass (CPB). The pathophysiology of injury..

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Intraoperative support during lung transplantation

Abstract The role of intraoperative mechanical support during lung transplantation (LTx) is essential to provide a safe hemodynamic and ventilatory status during critical intraoperative events. This hemodynamic and ventilatory stability..

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The Disconnect Between Extracorporeal Circulation and the Microcirculation

Abstract Extracorporeal circulation (ECC) procedures, such as cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO), take over the function of one or more organs, providing clinicians time to treat underlying..

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Pulsatil and NonPulsatil Current in Cardiopulmonary Bypass

Abstract Heart disease is among the most important health problems in our country and in the world. Heart diseases are widely repaired in adults, children and newborns with open heart..

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Neuroprotective strategies with circulatory arrest in open aortic surgery – A meta-analysis

Abstract Objective Deep hypothermic circulatory arrest (DHCA) in aortic surgery is associated with morbidity and mortality despite evolving strategies. With the advent of antegrade cerebral perfusion (ACP), moderate hypothermic circulatory..

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Cerebral oxygenation and autoregulation during rewarming on cardiopulmonary bypass

Abstract Background Rewarming on cardiopulmonary bypass (CPB) is associated with increased metabolic demands; however, it remains unclear whether cerebral autoregulation is affected during this phase. This RCT aims to describe..

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Independent Predictors of Postoperative Stroke With Cardiopulmonary Bypass

Abstract Objective To assess predictive factors of postoperative stroke in cardiac surgery using cardiopulmonary bypass (CPB). Design This study was a retrospective observational study. Setting This study was conducted at..

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Role of Platelets in Acute Lung Injury after Extracorporeal Circulation in Cardiac Surgery Patients: A systemic review

Abstract In vitro circulation (cardiopulmonary bypass, CPB) has been widely used in heart surgery. In the past, it was believed that the reduction of platelet count and impaired platelet function..

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Efficacy of Pulsatile Flow Perfusion in Adult Cardiac Surgery: Hemodynamic Energy and Vascular Reactivity

Abstract Background: The role of pulsatile (PP) versus non-pulsatile (NP) flow during a cardiopulmonary bypass (CPB) is still debated. This study’s aim was to analyze hemodynamic effects, endothelial reactivity and erythrocytes..

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The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats

Abstract Introduction Cardiopulmonary bypass (CPB) –induced lung ischemia-reperfusion (I/R) injury remains a large challenge in cardiac surgery; up to date, no effective treatment has been found. Annexin A1 (AnxA1) has..

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Targeted temperature management in cardiac surgery: a systematic review and meta-analysis on postoperative cognitive outcomes

Abstract Background Postoperative cognitive decline occurs commonly after cardiac surgery. The available literature is inconclusive on the role of intraoperative causal or protective factors. Methods We systematically reviewed studies evaluating..

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‘Goal-directed extracorporeal circulation: transferring the knowledge and experience from daily cardiac surgery to extracorporeal membrane oxygenation’

Abstract Metabolism management plays an essential role in extracorporeal technologies. There are different metabolic management devices integrated to extracorporeal devices; the most commonly used and accepted metabolic target in adult..

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Basics of Extracorporeal Membrane Oxygenation

History of extracorporeal membrane oxygenation  is the ability to supplement native pulmonary and/or cardiac function in the setting of native system failure. Development of modern  life support devices began with the..

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Bleeding Complications in Patients With Perioperative COVID-19 Infection Undergoing Cardiac Surgery: A Single-Center Matched Case-Control Study

Abstract Objective Previous studies reported a poor outcome in patients with coronavirus 2019 (COVID-19) undergoing cardiac surgery. Complications most frequently described were respiratory failure, renal failure, and thromboembolic events. In..

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Automatic control of blood flow rate on the arterial-line side during cardiopulmonary bypass

Abstract The operation of the cardiopulmonary bypass (CPB) system requires skilled techniques and experience. Intraoperatively, the perfusionist needs to intermittently manipulate both of the occluders on the venous- and arterial-line..

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Target blood pressure management during cardiopulmonary bypass improves lactate levels after cardiac surgery: a randomized controlled trial

Abstract Background Hyperlactatemia is associated with a poor prognosis in cardiac surgery patients. This study explored the impact of target blood pressure management during cardiopulmonary bypass (CPB) on blood lactate..

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Central, peripheral ECMO or CPB? Comparsion between circulatory support methods used during lung transplantation

Abstract Background Chronic obstructive pulmonary disease, cystic fibrosis and usual interstitial pneumonia are three most common indications for lung transplantation (LuTx) in Poland. As a result of irreversible destruction of..

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Minimally invasive extracorporeal circulation in end-stage coronary artery disease patients undergoing myocardial revascularization

Abstract Background Patients with coronary artery disease and concomitant heart failure (left ventricular ejection fraction < 35%) requiring myocardial revascularization are at risk of poor long-term prognosis and higher mortality. The benefits..

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Does severe hyperlactatemia during cardiopulmonary bypass predict a worse outcome?

Abstract Introduction The aim of the current study was to evaluate the impact of increased blood lactate levels during cardiopulmonary bypass (CPB) on immediate results in patients who underwent open..

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Developing a Quality Standard for Verbal Communication During CABG Procedures

Abstract Verbal communication during coronary artery bypass graft (CABG) procedures is essential for safe and efficient cardiac surgery, yet sensitive to failure due to a current lack of standardization. The..

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The association of thrombin generation with bleeding outcomes in cardiac surgery: a prospective observational study

Abstract Background Cardiac surgery with cardiopulmonary bypass (CPB) is associated with coagulopathic bleeding. Impaired thrombin generation may be an important cause of coagulopathic bleeding but is poorly measured by existing..

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Plasma from patients undergoing coronary artery bypass graft surgery does not activate endothelial cells under shear stress in vitro

Abstract Background: Cardiac surgery with cardiopulmonary bypass (CPB) is commonly associated with acute kidney injury, and microvascular endothelial inflammation is a potential underlying mechanism. We hypothesized that pro-inflammatory components of..

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