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Fifth-time redo mitral valve replacement via right thoracotomy under systemic hyperkalemia cardiopulmonary bypass without aortic cross-clamp

Abstract Five times of cardiac reoperations for PVE are a complex operation with significant risk. Due to the difficulty of aortic cross-clamping, mitral valve replacement (MVR) is performed under beating..

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Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks

Abstract Introduction: According to different authors, cardiac surgery-associated acute kidney injury (CSA-AKI) incidence can be as high as 20–50%. This complication increases postoperative morbidity and mortality and impairs long-term kidney..

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Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC)…

Abstract Background: The  during  (CPB) to improve Recovery in Infants with  (NITRIC) trial, a 1320-patient, multicentre, , is aiming to improve survival free of ventilation after CPB by using nitric oxide delivered into the  of the..

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Utility of heparin-binding protein following cardiothoracic surgery using cardiopulmonary bypass

Abstract Cardiothoracic surgery using cardiopulmonary bypass (CPB) triggers an inflammatory state that may be difficult to differentiate from infection. Heparin-binding protein (HBP) is a candidate biomarker for sepsis. As data..

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Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks

Abstract Introduction: According to different authors, cardiac surgery-associated acute kidney injury (CSA-AKI) incidence can be as high as 20–50%. This complication increases postoperative morbidity and mortality and impairs long-term kidney..

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Effect of cardiopulmonary bypass on coagulation factors II, VII and X in a primate model: an exploratory pilot study

Abstract OBJECTIVES The use of cardiopulmonary bypass (CPB) in cardiac surgery is a major risk factor for postoperative bleeding. We hypothesized that consumptive coagulopathy and haemodilution influence the coagulation factors;..

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Effects of blood transfusion, cardiopulmonary bypass time, and bypassed vessels on mortality following isolated and combined coronary artery bypass grafting

Abstract Objective: This study aimed to investigate the correlation between the number of bypassed vessels, the duration of Cardiopulmonary bypass, blood transfusion requirements, revision rates, and mortality outcomes. The objective..

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Diffuse Optical Monitoring of Cerebral Hemodynamics and Oxygen Metabolism during and after Cardiopulmonary Bypass: Hematocrit Correction and Neurological Vulnerability

Abstract Cardiopulmonary bypass (CPB) provides cerebral oxygenation and blood flow (CBF) during neonatal congenital heart surgery, but the impacts of CPB on brain oxygen supply and metabolic demands are generally..

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A Comparison of the Clinical Outcomes of Minimum and Maximum Hematocrit Levels During Cardiopulmonary Bypass (CPB) in Low-risk Patients Undergoing…

Abstract Background:  This study investigated the clinical outcomes at the minimum and maximum levels of hematocrit (HCT) during cardiopulmonary bypass (CPB) in low-risk patients undergoing coronary artery bypass graft (CABG)..

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Online interpretable dynamic prediction models for postoperative delirium after cardiac surgery under cardiopulmonary bypass developed based on machine learning algorithms:…

Abstract Objective: Postoperative delirium (POD) is strongly associated with poor early and long-term prognosis in cardiac surgery patients with cardiopulmonary bypass (CPB). This study aimed to develop dynamic prediction models for..

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Arterial Hyperoxemia During Cardiopulmonary Bypass Was Not Associated With Worse Postoperative Pulmonary Function: A Retrospective Cohort Study

Abstract BACKGROUND:  Arterial hyperoxemia may cause end-organ damage secondary to the increased formation of free oxygen radicals. The clinical evidence on postoperative lung toxicity from arterial hyperoxemia during cardiopulmonary bypass..

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Individualized heparin monitoring and management reduces protamine requirements in cardiac surgery on minimal invasive extracorporeal circulation; A prospective randomized study

Abstract Introduction Individualized heparin and protamine management is increasingly used as a strategy to reduce coagulation activation and bleeding complications. While it is associated with increased heparin requirements during Cardiopulmonary..

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Extracorporeal Circulation and Venous Hemodynamics: A Literature Review on Physiological Foundations to Clinical Applications

Abstract The venous system constitutes a vital component of the human circulatory system, facilitating the return of deoxygenated blood from tissues and organs back to the heart. During cardiac surgeries..

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Preoperative Sildenafil in Pediatric Patients Undergoing Congenital Heart Surgeries: A Systematic Review and Meta-Analysis

Abstract Background.  Pulmonary hypertension (PH) is a common complication of congenital heart disease (CHD). With early surgical intervention, outcomes have improved over the last two decades. Persistent PH, however, may..

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Antithrombin concentrates may benefit cardiopulmonary bypass patients with suspected heparin resistance: A retrospective analysis of real-world data

Abstract Background Heparin resistance is a common complication of surgical patients requiring anticoagulation, such as those undergoing cardiopulmonary bypass (CPB). Treatments to address heparin resistance include supplementation of antithrombin (AT)..

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A Decrease in Effective Renal Perfusion Pressure Is Associated With Increased Acute Kidney Injury in Patients Undergoing Cardiac Surgery

Abstract Purpose: This study aimed to evaluate the relationship between intra-abdominal pressure (IAP), renal perfusion indices, and postoperative acute kidney injury (AKI) in cardiac patients. Methods: In a prospective cohort..

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Dose Effect of Mesenchymal Stromal Cell Delivery Through Cardiopulmonary Bypass

Abstract Background Neurologic impairments are a significant concern for survivors after  cardiac surgery with  (CPB). We have previously shown that mesenchymal stromal cell (MSC) delivery through CPB has the potential to mitigate the effects..

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Gaseous Micro-Embolic Activity and Goal-Directed Perfusion Management in a Closed System for Cardiopulmonary Bypass and Minimally Invasive Extracorporeal Circulation during…

Abstract Background: Cardiopulmonary bypass (CPB) techniques are becoming minimally invasive in clinical practice. The literature describes various extracorporeal techniques which seek to eliminate air-blood contact and reduce both hemodilution and the..

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Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights

Abstract Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass (CPB) may develop several biochemical changes in the microcirculation that lead to a systemic inflammatory response. Surgical incision, post-CPB..

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NO Addition during Gas Oxygenation Reduces Liver and Kidney Injury during Prolonged Cardiopulmonary Bypass

Abstract Objective. To evaluate the effect of NO added to the sweep gas of the oxygenator during cardiopulmonary bypass (CPB) on the liver and kidneys in pigs.  Methods. An experiment..

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Carboxyhemoglobin and Methemoglobin Levels and Hemolysis in Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Abstract Hemolysis is a complication of cardiopulmonary bypass (CPB). Carboxyhemoglobin (COHb) and methemoglobin (MetHb) were suggested as potential hemolysis biomarkers. This retrospective study was based on a prospective registry aimed..

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Early outcome of simplified total arch reconstruction under mild hypothermia (30–32 °C) with distal aortic perfusion

Abstract Objective We designed a simplified total arch reconstruction (s-TAR) technique which could be performed under mild hypothermia (30–32 °C) with distal aortic perfusion. This study aimed to compare its efficacy..

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Hemolysis and cardiopulmonary bypass: meta-analysis and systematic review of contributing factors

Abstract Background The use of cardiopulmonary bypass (CPB) is almost inevitable in cardiac surgery. However, it can cause complications, including hemolysis. Until now, there have not been any standards for..

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Using the Anesthetic Gas Filter CONTRAfluran While on Cardiopulmonary Bypass: Preliminary Study of the Feasibility, Security, and Efficiency

Abstract The 2 hypnotic agents currently used for the maintenance of general anesthesia during cardiopulmonary bypass (CPB) are propofol and sevoflurane. Propofol can be administered directly into the cardiotome of..

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The incidence, risk factors and outcomes of impaired cerebral autoregulation in aortic arch surgery: a single-center, retrospective cohort study

Abstract Background Impairment of cerebral autoregulation (CA) has been observed in patients undergoing cardiopulmonary bypass (CPB), but little is known about its risks and associations with outcomes. The cerebral oximetry..

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Association of body mass index with perioperative blood transfusion and short-term clinical outcomes in patients undergoing isolated coronary artery bypass…

Abstract Background Few studies have considered outcomes among low body mass index (BMI) cohorts undergoing coronary artery bypass grafting (CABG). This study aims to investigate the effects of low body..

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Comparison of six percent hydroxyethyl starch 130/0.4 and ringer’s lactate as priming solutions in patients undergoing isolated open heart valve…

Abstract Objectives Colloids are added to the priming solution of the cardiopulmonary bypass (CPB) pump to maintain colloid osmotic pressure and prevent fluid overload. This study aimed to compare the..

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An In-Depth Analysis of the Multi-Faceted Benefits of Cytosorb Filter Utilization during Cardiopulmonary Bypass

Abstract Introduction: Cardiopulmonary bypass (CPB) is a vital component of many cardiac surgeries, but it can trigger systemic inflammatory responses, leading to post-operative complications. The CytoSorb filter, a cytokine adsorber, has..

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Does heparin rebound lead to postoperative blood loss in patients undergoing cardiac surgery with cardiopulmonary bypass?

Abstract Background Heparin rebound is a common observed phenomenon after cardiac surgery with CPB and is associated with increased postoperative blood loss. However, the administration of extra protamine may lead..

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Narrative Review of Systemic Inflammatory Response Mechanisms in Cardiac Surgery and Immunomodulatory Role of Anesthetic Agents

Abstract Although surgical techniques and perioperative care have made significant advances, perioperative mortality in cardiac surgery remains relatively high. Single- or multiple-organ failure remains the leading cause of postoperative mortality...

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