Archives

Perfusfind S.L.

Abstract Objective  (FXII) is a multifunctional  capable of activating thrombotic and inflammatory pathways. FXII has been linked to thrombosis in  (ECMO), but the role of FXII in ECMO-induced inflammatory complications has not..

Perfusfind S.L.

Abstract Drainage insufficiency is a common phenomenon during extracorporeal life support, related to a variable and potentially multiple etiologies. Being associated with impaired extracorporeal blood flow (EBF), so with impaired..

Perfusfind S.L.

Abstract Heparin-induced thrombocytopenia (HIT) is a major issue in cardiac surgery requiring cardiopulmonary bypass (CPB). HIT represents a severe adverse drug reaction after heparin administration. It consists of immune-mediated thrombocytopenia..

Perfusfind S.L.

Abstract Background A multidisciplinary Quality Assurance/Performance Improvement study to identify the incidence of “heparin rebound” in our adult cardiac surgical population instead detected a thromboelastometry pattern suggestive of initial protamine..

Perfusfind S.L.

Abstract Background: Patient blood management (PBM) is a multidisciplinary and patient-centered treatment approach, comprising the detection and treatment of anemia, the minimization of blood loss, and the rational use of allogeneic..

Perfusfind S.L.

Abstract Pathophysiology There are two types of HIT, depending on the absence or presence of an immune mediation. Type 1 is a non-immune-mediated direct activation of platelets by heparin that..

Perfusfind S.L.

Abstract Background The aim of this retrospective observational study was to explore the early predictive parameters for maximum amplitude in the kaolin with heparinase (HKH) assay (MAHKH) of TEG6s Platelet Mapping..

Perfusfind S.L.

Abstract Background: Cell-derived microparticles (MPs) as membrane vesicles are procoagulant. They play a role in surgical hemostasis. In this study, the correlations between the circulating level of cell-derived MPs and..

Perfusfind S.L.

Abstract BACKGROUND:  Heparin resistance (HR) is a common finding in pediatric cardiac surgery and generally refers to decreased sensitivity to heparin. Antithrombin (AT) deficiency is considered the primary mechanism of..

Perfusfind S.L.

Abstract The Aeson total artificial heart provides right- and left-sided heart replacement for biventricular failure with notable improvements from prior generations. These include enhanced hemocompatibility and autoregulation enabling increased output in..

Perfusfind S.L.

Abstract Objective: Extracorporeal membrane oxygenation (ECMO) utilization is increasing on a global scale, and despite technological advances, minimal standardized approaches to pharmacotherapeutic management exist. This objective was to create a..

Perfusfind S.L.

Abstract Objective Heparin resistance is often encountered during cardiopulmonary bypass. Heparin dose and activated clotting time target values for the initiation of cardiopulmonary bypass are not yet universally standardized; further..

Perfusfind S.L.

Abstract Background and Objective: Resuscitative therapies for respiratory and cardiac failure are lifesaving and extended by using extracorporeal life support (ECLS) as mechanical circulatory support (MSC). This review informs the debate..

Perfusfind S.L.

Abstract Objective The purpose of this study was to explore the relationship between platelet concentration (PLT) (× 109/L) and clot strength measured by  maximum amplitude (TEG-MA) in healthy volunteers without a..

Perfusfind S.L.

Abstract Background A strategy that limits tidal volumes and inspiratory pressures, improves outcomes in patients with the acute respiratory distress syndrome (ARDS). Extracorporeal carbon dioxide removal (ECCO2R) may facilitate ultra-protective ventilation...

Perfusfind S.L.

Abstract Amniotic fluid embolism (AFE) is a potentially lethal complication of pregnancy that results from disruption of the maternal–fetal interface and occurs as frequently as one in every 8,000 deliveries. When AFE..

Perfusfind S.L.

Abstract Objectives Viscoelastic tests allow a reduction in blood product transfusion. Three modern devices are currently available (rotational  [ROTEM] sigma,  [TEG] 6S, and Quantra). No study has compared the performances of these..

Perfusfind S.L.

Abstract Pediatric Literature As the practice of ultrafiltration arose from pediatric cardiac surgery, much of the evidence to support MUF is from low-powered pediatric studies. Some early, single-center literature, as..

Perfusfind S.L.

Abstract Hemodilution and Volume Overload The use of CPB necessitates priming of the CPB circuit, which is typically accomplished using 1-to-2 liters of a crystalloid solution. In addition, 1-to-3 liters..

Perfusfind S.L.

Abstract Background The purpose of this study was to analyze the results of Cytosorb (CytoSorbents, Monmouth Junction, NJ) adsorption during emergency open heart operations in patients at high risk of..

Perfusfind S.L.

Abstract Objective There is limited evidence on standardized protocols for optimal neurological monitoring methods  receiving  (ECMO). We previously introduced protocolized noninvasive multimodal neuromonitoring using serial , electroencephalography,  ultrasound, and . The purpose of this study..

Perfusfind S.L.

Abstract Background We used sodium citrate as an alternative anticoagulation agent to heparin in the procedure of autologous blood transfusion with patients with postoperative haemorrhage after CPB. The aim of..

Perfusfind S.L.

Abstract Background Heparin-induced thrombocytopenia (HIT) is a common differential diagnosis in cardiothoracic surgery. The latex immunoturbidimetric assay (LIA) is an enhanced immunoassay that has recently been introduced for the detection..

Perfusfind S.L.

Abstract Background Fibrinogen γ-chain peptide-coated, adenosine 5'-diphosphate (ADP)-encapsulated liposomes (H12-ADP-liposomes) are potent hemostatic adjuvants that promote platelet thrombi formation at bleeding sites. Although we have reported the efficacy of these..

Perfusfind S.L.

Abstract Because of its rapid onset and offset of action, and its ability to be fully and rapidly reversed with protamine when anticoagulation control is needed, unfractionated heparin (UFH) remains..

Perfusfind S.L.

Abstract Hemorrhage remains a major complication of anticoagulants, with bleeding leading to serious and even life-threatening outcomes in rare settings. Currently available anticoagulants target either multiple coagulation factors or specifically..

Perfusfind S.L.

Abstract Background Cell salvage reduces allogenic blood transfusion requirements in surgery. We present a pilot study exploring the impact of anticoagulant choice, citrate or heparin, on the quality of cell..

Perfusfind S.L.

Abstract Background Anticoagulation is critical in patients supported on extracorporeal membrane oxygenation (ECMO). The appropriate monitoring strategies for heparin remain unclear. Objectives This systematic review aimed to compare the accuracy..

Perfusfind S.L.

Abstract A neonate with pulmonary hypertension was supported with extracorporeal membrane oxygenation (ECMO). During ECMO support, the patient developed Enterococcus faecalis bacteremia, treated with targeted antibiotics. Despite the maximum dose of antibiotics, routine blood..

Perfusfind S.L.

Abstract Bleeding is a leading cause of perioperative mortality []. In a perioperative setting, damage control surgery with massive transfusion protocols (MTPs) are therapeutic approaches used clinically to manage patients..